STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO5622SC2E1.39, possible transcriptional regulator, len: 185 aa; equivalent to Streptomyces roseosporus TR:P72569 (EMBL:U58281) tetR homologue WhiR (179 aa) (86.6% identity in 179 aa overlap) and similar to several putative transcriptional regulators of the tetR family e.g. TR:E1247678 putative transcriptional regulator SC10A5.11 (S.coelicolor) (198 aa), fasta scores; opt: 434 z-score: 720.5 E(): 6.8e-33, 41.5% identity in 171 aa overlap. Contains probable helix-turn-helix motif at aa 29 to 50 (Score 1618, +4.70 SD) and Pfam match to entry tetR PF00440, Bacterial regulatory proteins, tetR fa [...] (185 aa)    
Predicted Functional Partners:
SCO5621
RNA polymerase sigma factor WhiG; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
     0.799
SCO2665
Hypothetical protein SC6D10.08; SC6D10.08, unknown, len: 444 aa. Contains possible coiled-coil region.
  
     0.663
SCO3840
Hypothetical protein; SCH69.10c, unknown, len: 271aa; similar to TR:P74322 (EMBL:D90914) from Synechocystis sp. PCC6803 (228 aa) fasta scores; opt: 238, z-score: 277.0, E(): 4.2e-08, (26.6% identity in 259 aa overlap). Contains possible coiled-coil at 30-40aa.
  
     0.638
SCO5220
Hypothetical protein SC7E4.17; SC7E4.17, unknown, len: 326 aa.
  
 
   0.624
SCO3624
SCH10.02, hypothetical protein, len: 221 aa; unknown function, probable CDS suggested by positional base preference, GC frame analysis and amino acid composition.
  
     0.594
SCO4400
SCD10.32, possible membrane protein, len: 531 aa. Contains possible hydrophobic membrane spanning region and high content in alanine, glycine and proline amino acid residues. Also high G+C content (79.03%) and a 3x degenerate repeat unit: GGR.
  
     0.577
SCO5721
SC3C3.07, unknown, len: 508 aa; similar to three hypothetical proteins from M. tuberculosis e.g. TR:O06317 (EMBL:Z95390) MTCY13E12.03C (470 aa), fasta scores; opt: 213 z-score: 330.7 E(): 3.7e-11, 28.0% identity in 508 aa overlap. Contains possible transmembrane domain at N-terminus.
  
     0.566
SCO5735
SC3C3.21, probable integral membrane protein, len: 491 aa; similar to hypothetical membrane protein from M. tuberculosis TR:O06265 (EMBL:Z95389) MTCY77.20 Rv3448 (467 aa), fasta scores; opt: 192 z-score: 322.0 E(): 1.1e-10, 26.9% identity in 495 aa overlap.
  
     0.562
SCO5595
50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
       0.560
SCO5596
SC2E1.13, sip1, probable signal peptidase I, len: 259 aa; similar to many e.g. LEP_HAEIN signal peptidase I (EC 3.4.21.89) (349 aa), fasta scores; opt: 162 z-score: 381.2 E(): 5.3e-14, 32.5% identity in 243 aa overlap, though with large internal deletions. Contains PS00761 Signal peptidases I signature 3, Pfam match to entry signal_pept_I PF00461, Signal peptidases I, score 51.12 and probable transmembrane domain. Also similar to downstream genes sip2 (E(): 9.7e-26, 44.9% identity in 274 aa overlap), sip3 (E(): 4.8e-16, 35.6% identity in 264 aa overlap) and sip4 (E(): 8.7e-08, 37.0% id [...]
       0.560
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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