STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO5648ABC transporter ATP binding protein; Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import. Responsible for energy coupling to the transport system. (348 aa)    
Predicted Functional Partners:
SCO5647
SC6A9.20c, probable ABC transporter integral membrane protein, len: 553 aa; similar to many e.g. Y4FN_RHISN probable ABC transporter permease protein (569 aa), fasta scores; opt: 296 z-score: 555.5 E(): 1e-23, 25.4% identity in 563 aa overlap. Contains 2x Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, scores 40.70, E-value 3.2e-08 and 46.50, E-value 6.1e-10.
 
 
 0.992
SCO5646
SC6A9.21c, probable solute binding lipoprotein, len: 373 aa; similar to e.g. TBPA_ECOLI thiamin-binding periplasmic protein (327 aa), fasta scores; opt: 220 z-score: 423.3 E(): 2.4e-16, 28.4% identity in 327 aa overlap. Contains N-terminla signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
 
  
 0.982
SCO5669
SC8B7.09c, probable polyamine ABC-transporter integr al membrane protein, len: 309 aa; similar to many e.g. POTB _ECOLI spermidine/putrescine transport system permease (275 aa), fasta scores; opt: 548 z-score: 685.1 E(): 6.6e-31, 3 6.9% identity in 274 aa overlap. Contains Pfam match to ent ry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 38.20, E-value 1.8e -07.
 
 0.905
SCO5670
SC8B7.08c, probable polyamine ABC-transporter integr al membrane protein, len: 266 aa; similar to many e.g. POTC _ECOLI spermidine/putrescine transport system permease (264 aa), fasta scores; opt: 579 z-score: 718.8 E(): 8.8e-33, 3 5.5% identity in 251 aa overlap. Contains Pfam match to ent ry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 23.00, E-value 0.00 7.
 
  
 0.868
SCO3454
SCE46.11c, possible ABC-transporter membrane protein, len: 280 aa; similar to TR:Q44381 (EMBL:U60011) Agrobacterium tumefaciens inner membrane protein MotD, 273 aa; fasta scores: opt: 360 z-score: 418.0 E(): 6.1e-16; 29.3% identity in 256 aa overlap and to SW:POTC_ECOLI (EMBL:M64519) Escherichia coli spermidine/putrescine transport system permease protein PotC, 264 aa; fasta scores: opt: 309 z-score: 360.4 E(): 1e-12; 25.8% identity in 260 aa overlap. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component and Prosite match [...]
 
  
 0.837
SCO5658
SC6A9.09c, possible polyamine-binding lipoprotein, len: 399 aa; some similarity to several spermidine.
 
  
 0.768
SCO5667
SC8B7.11c, probable ABC-transporter polyamine-binding lipoprotein, len: 399 aa; similar to e.g. POTF_ECOLI putrescine-binding periplasmic protein precursor (370 aa), fasta scores; opt: 327 z-score: 259.5 E(): 3.4e-07, 28.5% identity in 365 aa overlap. Also similar to upstream gene SC6A9.09c (E(): 0, 46.8% identity in 391 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site and PS00017 ATP/GTP-binding site motif A (P-loop). Contains possible N-terminal region signal sequence peptide.
 
  
 0.757
SCO5645
Conserved hypothetical protein SC6A9.22c; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family.
  
    0.746
SCO5649
Conserved hypothetical protein; SC6A9.18c, unknown, len: 266 aa; similar to M. tuberculosis hypothetical protein TR:O07256 (EMBL:Z96800) MTCY63.37 (261 aa), fasta scores; opt: 508 z-score: 606.3 E(): 1.6e-26, 36.7% identity in 251 aa overlap.
       0.746
SCO4781
SCD63.13, possible cholesterol oxidase, len: 602 aa; similar to TR:Q59530 (EMBL:U00015) Mycobacterium leprae probable cholesterol oxidase precursor (EC 1.1.3.6) ChoD, 585 aa; fasta scores: opt: 1114 z-score: 1181.0 E(): 0; 60.5% identity in 583 aa overlapand to SW:CHOD_BREST (EMBL:D00712) Brevibacterium sterolicum cholesterol oxidase precursor (EC 1.1.3.6) ChoD, 552 aa; fasta scores: opt: 228 z-score: 244.5 E(): 3.4e-06; 26.9% identity in 576 aa overlap.
      
 0.729
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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