STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO5658SC6A9.09c, possible polyamine-binding lipoprotein, len: 399 aa; some similarity to several spermidine. (399 aa)    
Predicted Functional Partners:
SCO5670
SC8B7.08c, probable polyamine ABC-transporter integr al membrane protein, len: 266 aa; similar to many e.g. POTC _ECOLI spermidine/putrescine transport system permease (264 aa), fasta scores; opt: 579 z-score: 718.8 E(): 8.8e-33, 3 5.5% identity in 251 aa overlap. Contains Pfam match to ent ry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 23.00, E-value 0.00 7.
 
 0.998
SCO5669
SC8B7.09c, probable polyamine ABC-transporter integr al membrane protein, len: 309 aa; similar to many e.g. POTB _ECOLI spermidine/putrescine transport system permease (275 aa), fasta scores; opt: 548 z-score: 685.1 E(): 6.6e-31, 3 6.9% identity in 274 aa overlap. Contains Pfam match to ent ry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 38.20, E-value 1.8e -07.
 
 
 0.992
SCO5668
Putative polyamine ABC-transporter ATP-binding p rotein; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
 
 
 0.985
SCO3454
SCE46.11c, possible ABC-transporter membrane protein, len: 280 aa; similar to TR:Q44381 (EMBL:U60011) Agrobacterium tumefaciens inner membrane protein MotD, 273 aa; fasta scores: opt: 360 z-score: 418.0 E(): 6.1e-16; 29.3% identity in 256 aa overlap and to SW:POTC_ECOLI (EMBL:M64519) Escherichia coli spermidine/putrescine transport system permease protein PotC, 264 aa; fasta scores: opt: 309 z-score: 360.4 E(): 1e-12; 25.8% identity in 260 aa overlap. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component and Prosite match [...]
 
  
 0.919
SCO5667
SC8B7.11c, probable ABC-transporter polyamine-binding lipoprotein, len: 399 aa; similar to e.g. POTF_ECOLI putrescine-binding periplasmic protein precursor (370 aa), fasta scores; opt: 327 z-score: 259.5 E(): 3.4e-07, 28.5% identity in 365 aa overlap. Also similar to upstream gene SC6A9.09c (E(): 0, 46.8% identity in 391 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site and PS00017 ATP/GTP-binding site motif A (P-loop). Contains possible N-terminal region signal sequence peptide.
  
  
0.912
SCO5671
SC8B7.07c, possible oxidoreductase, len: 475 aa; some similarity to e.g. ORDL_ECOLI probable oxidoreductase ord L (426 aa), fasta scores; opt: 413 z-score: 280.3 E(): 2.4 e-08, 32.1% identity in 436 aa overlap.
 
   
 0.862
SCO5057
SCK7.30c, possible amino acid permease, len: 460 aa; similar to SW:MMUP_ECOLI (EMBL:D83536) Escherichia coli probable S-methylmethionine permease MmuP, 475 aa; fasta scores: opt: 345 z-score: 390.5 E(): 2.8e-14; 23.3% identity in 408 aa overlap and to TR:P74848 (EMBL:X99945) Salmonella typhimurium amino acid permease YeeF like protein, 448 aa; fasta scores: opt: 705 z-score: 792.4 E(): 0; 32.0% identity in 416 aa overlap. Contains Pfam match to entry PF00324 aa_permeases, Amino acid permease and possible hydrophobic membrane spanning regions.
      
 0.856
SCO5655
SC6A9.12, probable aminotransferase, len: 457 aa; similar to many e.g. BIOA_BACSU adenosylmethionine-8-amino-7-oxononanoate aminotransferase (448 aa), fasta scores; opt: 895 z-score: 881.6 E(): 0, 35.6% identity in 449 aa overlap. Also highly similar to M. tuberculosis putative aminotransferase TR:O53379 (EMBL:AL021841) MTV016.29; 70.3% identity in 438 aa overlap. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate, score 355.70, E-value 3.5e-123; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
 
  
 0.799
SCO3453
SCE46.10c, probable ABC-transporter ATP binding protein, len: 354 aa; similar to TR:CAB49712 (EMBL:AJ248285) Pyrococcus abyssi ABC-transporter ATP binding protein, 329 aa; fasta scores opt: 708 z-score: 742.4 E(): 0; 43.9% identity in 280 aa overlap and to SW:CYSA_ECOLI (EMBL:M32101) Escherichia coli sulfate transport ATP-binding protein CysA, 365 aa; fasta scores: opt: 668 z-score: 700.3 E(): 1.2e-31; 38.6% identity in 332 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter and two matches to Prosite entries PS00211 ABC transporters family signature and PS00017 [...]
 
   
 0.780
SCO5659
SC6A9.08c, possible integral membrane protein, len: 179 aa; contains four possible transmembrane domains.
       0.772
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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