STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO5739Putative dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (250 aa)    
Predicted Functional Partners:
SCO1912
Putative dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
 
 
 0.990
SCO5744
Putative dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
 
 
 0.990
SCO1916
Putative transferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
 
 
 0.983
SCO1889
SCI7.07c, probable dihydropicolinate synthase, len: 302 aa; similar to many e.g. SW:DAPA_BACSU dihydropicolinate synthase from Bacillus subtilis (290 aa) fasta scores; opt: 280, z-score: 323.5, E(): 1.1e-10, (28.2% identity in 284 aa overlap). Contains Pfam match to entry PF00701 DHDPS, Dihydrodipicolinate synthetase family.
  
 
 0.961
SCO5740
SC9A10.04, possible membrane protein, len: 151 aa; similar to hypothetical proteins from Mycobacterium bovis and tuberculosis that follow dapB, e.g. YDAB_MYCBO hypothetical 19.3 kd protein in dapb 3'region (177 aa), fasta scores; opt: 377 z-score: 696.1 E(): 1.7e-31, 47.1% identity in 136 aa overlap.
     
 0.949
SCO5738
SC9A10.02, probable protease, len: 459 aa; similar to members of the insulinase family e.g. YMXG_BACSU hypothetical processing protease (409 aa), fasta scores; opt: 648 z-score: 1449.2 E(): 0, 39.7% identity in 413 aa overlap and MPP2_YEAST mitochondrial processing peptidase beta subunit (462 aa), fasta scores; opt: 583 z-score: 864.6 E(): 0, 29.7% identity in 448 aa overlap. Alternative start possible at aa 36. Contains PS00143 Insulinase family, zinc-binding region signature and Pfam match to entry PF00675 Insulinase, Insulinase (proteinase M16), score 171.30, E-value 1.6e-47.
  
  
 0.942
SCO5737
Guanosine pentaphosphate synthetase/polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.
     
 0.908
SCO5793
Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan.
 
   
 0.901
SCO3614
Putative aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family.
 
  
 0.884
SCO5353
Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine.
 
  
 0.868
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.