node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SCO1380 | SCO1519 | gene:17758963 | gene:17759105 | Putative DNA damage inducible protein; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | Holliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.639 |
SCO1380 | SCO1738 | gene:17758963 | gene:17759332 | Putative DNA damage inducible protein; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | SCI11.27c, conserved hypothetical protein, len: 322 aa; similar to many hypothetical proteins related to the impB/mucB/samB family e.g. TR:Q10787 (EMBL:Z74020) Mycobacterium tuberculosis hypothetical protein (463 aa), fasta scores; opt: 330 z-score: 372.5 E(): 2.1e-13, 29.5% identity in 281 aa overlap. | 0.511 |
SCO1380 | SCO1780 | gene:17758963 | gene:17759374 | Putative DNA damage inducible protein; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | Putative DNA repair protein; May be involved in recombinational repair of damaged DNA. | 0.487 |
SCO1380 | SCO1953 | gene:17758963 | gene:17759550 | Putative DNA damage inducible protein; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | ABC excision nuclease subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.472 |
SCO1380 | SCO5769 | gene:17758963 | gene:17763429 | Putative DNA damage inducible protein; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.871 |
SCO1380 | SCO5803 | gene:17758963 | gene:17763463 | Putative DNA damage inducible protein; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | SOS regulatory protein; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.940 |
SCO1519 | SCO1380 | gene:17759105 | gene:17758963 | Holliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | Putative DNA damage inducible protein; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | 0.639 |
SCO1519 | SCO1780 | gene:17759105 | gene:17759374 | Holliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | Putative DNA repair protein; May be involved in recombinational repair of damaged DNA. | 0.916 |
SCO1519 | SCO1953 | gene:17759105 | gene:17759550 | Holliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | ABC excision nuclease subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.929 |
SCO1519 | SCO5769 | gene:17759105 | gene:17763429 | Holliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.898 |
SCO1519 | SCO5803 | gene:17759105 | gene:17763463 | Holliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | SOS regulatory protein; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.749 |
SCO1576 | SCO1780 | gene:17759169 | gene:17759374 | Arginine repressor; Regulates arginine biosynthesis genes. | Putative DNA repair protein; May be involved in recombinational repair of damaged DNA. | 0.478 |
SCO1576 | SCO2555 | gene:17759169 | gene:17760157 | Arginine repressor; Regulates arginine biosynthesis genes. | Heat-inducible transcriptional repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.704 |
SCO1576 | SCO5803 | gene:17759169 | gene:17763463 | Arginine repressor; Regulates arginine biosynthesis genes. | SOS regulatory protein; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.742 |
SCO1738 | SCO1380 | gene:17759332 | gene:17758963 | SCI11.27c, conserved hypothetical protein, len: 322 aa; similar to many hypothetical proteins related to the impB/mucB/samB family e.g. TR:Q10787 (EMBL:Z74020) Mycobacterium tuberculosis hypothetical protein (463 aa), fasta scores; opt: 330 z-score: 372.5 E(): 2.1e-13, 29.5% identity in 281 aa overlap. | Putative DNA damage inducible protein; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | 0.511 |
SCO1738 | SCO1780 | gene:17759332 | gene:17759374 | SCI11.27c, conserved hypothetical protein, len: 322 aa; similar to many hypothetical proteins related to the impB/mucB/samB family e.g. TR:Q10787 (EMBL:Z74020) Mycobacterium tuberculosis hypothetical protein (463 aa), fasta scores; opt: 330 z-score: 372.5 E(): 2.1e-13, 29.5% identity in 281 aa overlap. | Putative DNA repair protein; May be involved in recombinational repair of damaged DNA. | 0.470 |
SCO1738 | SCO5769 | gene:17759332 | gene:17763429 | SCI11.27c, conserved hypothetical protein, len: 322 aa; similar to many hypothetical proteins related to the impB/mucB/samB family e.g. TR:Q10787 (EMBL:Z74020) Mycobacterium tuberculosis hypothetical protein (463 aa), fasta scores; opt: 330 z-score: 372.5 E(): 2.1e-13, 29.5% identity in 281 aa overlap. | Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.821 |
SCO1738 | SCO5803 | gene:17759332 | gene:17763463 | SCI11.27c, conserved hypothetical protein, len: 322 aa; similar to many hypothetical proteins related to the impB/mucB/samB family e.g. TR:Q10787 (EMBL:Z74020) Mycobacterium tuberculosis hypothetical protein (463 aa), fasta scores; opt: 330 z-score: 372.5 E(): 2.1e-13, 29.5% identity in 281 aa overlap. | SOS regulatory protein; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.876 |
SCO1780 | SCO1380 | gene:17759374 | gene:17758963 | Putative DNA repair protein; May be involved in recombinational repair of damaged DNA. | Putative DNA damage inducible protein; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | 0.487 |
SCO1780 | SCO1519 | gene:17759374 | gene:17759105 | Putative DNA repair protein; May be involved in recombinational repair of damaged DNA. | Holliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.916 |