STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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SCO5841Phosphocarrier protein hpr; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain. (93 aa)    
Predicted Functional Partners:
SCO1391
Phosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
 
 0.999
SCO3196
SCE22.13c, probable fructose-specific permease, len: 699 aa; similar to SW:PTFB_ECOLI (EMBL:M23196) Escherichia coli PTS system, fructose-specific IIBC component (EIIBC-fru) FruA 563 aa; fasta scores: opt: 1006 z-score: 1038.9 E(): 0; 43.7% identity in 583 aa overlap. Contains match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. and possible hydrophobic membrane spanning regions in C-terminal domain.
 
 
 0.999
SCO1390
SC1A8A.10, possible PTS system sugar phosphotransferase component IIA, len: 176a; similar to many e.g. TR:BAA82669 (EMBL:AB030569) putative phosphoenolpyruvate:carbohydrate phosphotransferase system family from Streptomyces griseus (149 aa) fasta scores; opt: 897, z-score: 951.7, E(): 0, 88.6% identity in 149 aa overlap and SW:P42015 (PTGA_BACST) PTS system, glucose-specific IIABC component from Bacillus stearothermophilus (324 aa) fasta scores; opt: 359, z-score: 386.4, E(): 4.3e-14, 40.6% identity in 143 aa overlap. Contains Pfam match to entry PF00358 PTS_EIIA_1, phosphoenolpyruvate [...]
 
 0.998
SCO2907
Putative PTS transmembrane component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylglucosamine (GlcNAc) transport. High-affinity permease, which exhibits a narrow specificity for GlcNAc. Essential for C-signaling between vegetative growth and development.
 
 
 0.978
SCO2906
SCE19A.06, possible PTS transmembrane component, len: 431 aa; similar to many PTS (phosphoenolpyruvate-dependent sugar phosphotransferase system) transmembrane and sugar-binding components e.g. TR:Q57071 (EMBL:X93360), GlcA, PtsG, Staphylococcus carnosus PTS system, glucose-specific IIABC component (675 aa), fasta scores; opt: 1120 z-score: 1260.6 E(): 0, 43.4% identity in 431 aa overlap. Similar to the adjacent CDS SCE19A.07, possible PTS transmembrane component (416 aa) (4.1% identity in 429 aa overlap).The homologous PTS family proteins have a C-terminal extension not present in thi [...]
 
 
 0.974
SCO0434
SCF51A.12, malX, sugar phosphotransferase, len: 549 aa. Highly similar to Escherichia coli SW:PTOA_ECOLI (EMBL; M60722) PTS system, maltose and glucose-specific II ABC component (maltose and glucose-permease II ABC component) (phosphotransferase enzyme II, ABC component) (EC 2.7.1.69) (523 aa), fasta scores opt: 1852 z-score: 2064.1 E():0 59.5% identity in 543 aa overlap. Contains a Pfam match to entry PF00367 PTS_EIIB, phosphotransferase system, EIIB and a Prosite hit to PS01035 PTS EIIB domains cysteine phosphorylation site signature. Contains multiple possible membrane spanning hydr [...]
 
 
 0.973
SCO0137
Possible sugar-transport protein; SCJ21.18c, unknown, partial CDS, len >170 aa; SCJ33.01c, putative sugar-transport protein, partial CDS, len: > 138 aa. Similar to many e.g. Escherichia coli SW: PTXA_ECOLI (EMBL; U14003) unknown pentitol phosphotransferase enzyme II, A component (EC 2.7.1.69) (154 aa), fasta scores opt: 313 z-score: 403.6 E(): 4.1e-15 38.3% identity in 133 aa overlap. Overlaps with and extends into CDS SCJ21.18c. Contains a Pfam match to entry PF00359 PTS_EIIA_2, phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2.
 
 
 0.968
SCO0136
SCJ21.17c, probable integral membrane protein, len: 516 aa; similar to SGAT_ECOLI putative transport protein SGAT (484 aa), fasta scores; opt: 339 z-score: 341.6 E(): 1.1e-11, 28.5% identity in 414 aa overlap. Contains probable membrane spanning hydrophobic domains.
 
  
 0.939
SCO3197
SCE22.14c, probable 1-phosphofructokinase, len: 315 aa; similar to SW:K1PF_RHOCA (EMBL:X53150) Rhodobacter capsulatus 1-phosphofructokinase (EC 2.7.1.56) (fructose 1-phosphate kinase) FruK, 316 aa; fasta scores: opt: 555 z-score: 576.5 E(): 1.2e-24; 37.8% identity in 315 aa overlap. Contains Pfam match to entry PF00294 pfkB, pfkB family carbohydrate kinase and match to Prosite entry PS00583 pfkB family of carbohydrate kinases signature 1.
 
  
 0.831
SCO4660
30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family.
  
  
 0.794
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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