STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO5860SC2E9.01, suhB, probable extragenic suppressor protein, partial CDS, len: >209 aa, similar to eg. SUHB_ECOLI P22783 extragenic suppressor protein Suhb (267 aa), fasta scores; opt: 448 z-score: 565.9 E(): 2.5e-24, 41.0% identity in 212 aa overlap, and to eg. MYO2_LYCES P54927 myo-inositol-1(or 4)-monophosphatase (265 aa), fasta scores; opt: 359 z-score: 450.8 E(): 6.6e-18, 38.7% identity in 199 aa overlap. Contains PS00629 and PS00630 Inositol monophosphatase family signatures 1 and 2 and Pfam match to entry inositol_P PF00459, Inositol monophosphatase family, score 64.03. Overlaps and [...] (272 aa)    
Predicted Functional Partners:
SCO3243
SCE29.12c, possible myo-inositol phosphate synthase, len: 388 aa; similar to many e.g. TR:O69948 (EMBL:AL023862) from Streptomyces coelicolor (417 aa) fasta scores; opt: 955, z-score: 1034.1, E(): 0, (60.3% identity in 380 aa overlap) and SW:INO1_CITPA myo-inositol phosphate synthase from Citrus paradisi (grapefruit) fasta scores; opt: 323, z-score: 352.1, E(): 2.6e-12, (26.9% identity in 364 aa overlap).
  
 
 0.979
SCO6573
SC3F9.08, probable secreted protein, len: 417 aa; some similarity to many eukaryotic myo-inositol-1-phosphate synthases e.g. INO1_SPIPO (510 aa), fasta scores; opt: 159 z-score: 190.1 E(): 0.0022, 28.1% identity in 423 aa overlap, and to Archaeoglobus fulgidus TR:O28480 (EMBL:AE000979) AF1794 (392 aa), fasta scores; opt: 546 z-score: 713.5 E(): 1.6e-32, 37.0% identity in 397 aa overlap. Contains possible N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
  
 
 0.979
SCO3899
SCH24.21c, conserved hypothetical protein, len: 360 aa; unknown function, similar to e.g. TR:P71703 (EMBL:Z80775) Mycobacterium tuberculosis hypothetical protein (367 aa), fasta scores; opt: 1790 z-score: 2136.2 E(): 0, 78.5% identity in 353 aa overlap. C-terminal half shows weak similarity with a region of SW:INO1_CANAL (EMBL:L22737), Ino1, Candida albicans myo-inositol-1-phosphate synthase (520 aa) (26.3% identity in 251 aa overlap) and with TR:O69948 (EMBL:AL023862) S.coelicolor probable secreted protein (417 aa) (25.2% identity in 226 aa overlap).
  
 
 0.975
SCO7254
Putative myo-inositol dehydrogenase; Involved in the oxidation of myo-inositol (MI) to 2-keto-myo- inositol (2KMI or 2-inosose).
    
 0.951
SCO0479
SCF76.19c, putative phosphatase, len: 274 aa. Almost identical to Streptomyces lividans TR:O70034 (EMBL; AJ223365) Sbl1 gene (274 aa), fasta scores opt: 1764 z-score: 2005.4 E():0 97.1% identity in 274 aa overlap. Also weakly similar to many inositol monophosphatases e.g. Mycobacterium smegmatis TR:O51845 (EMBL; AF005905) inositol monophosphate phosphatase (276 aa), fasta scores opt: 299 z-score: 346.7 E(): 6e-12 33.1% identity in 269 aa overlap and Escherichia coli SW: SUHB_ECOLI (EMBL; M34828) extragenic suppressor protein SuhB (267 aa), fasta scores opt: 269 z-score: 313.0 E(): 4.6e [...]
  
  
0.914
SCO6255
SCAH10.20, possible dehydrogenase, len: 337 aa; similar to SW:STRI_STRGR (EMBL:Y00459) Stretomyces griseus streptomycin resistance protein StrI, 348 aa; fasta scores: opt: 582 z-score: 670.0 E(): 6.1e-30; 39.5% identity in 344 aa overlap and to SW:MI2D_BACSU (EMBL;M76431) Bacillus subtilis myo-inositol dehydrogenase (EC 1.1.1.18) Idh or IolG OR e83G, 330 aa; fasta scores: opt: 534 z-score: 615.6 E(): 6.5e-27; 28.8% identity in 351 aa overlap. Contains match to Pfam entry PF01408 GFO_IDH_MocA, oxidoreductase family.
    
 0.904
SCO6984
Putative oxidoreductase; SC8F11.10c, possible oxidoreductase, len: 358 aa. Similar to many including: Sinorhizobium meliloti TR:O68965(EMBL:) myo-inositol dehydrogenase (EC 1.1.1.18) IdhA (330 aa), fasta scores opt: 715 z-score: 789.8 E(): 0 39.6% identity in 338 aa overlap and Streptomyces coelicolor TR:CAB60174(EMBL:AL132824) putative dehydrogenase, SCAH10.20C (337 aa), fasta scores opt: 1068 z-score: 1176.0 E(): 0 50.8% identity in 333 aa overlap. Note codon 25 offers an alternative translational start site. Contains a Pfam match to entry PF01408 GFO_IDH_MocA, Oxidoreductase family.
    
 0.904
SCO6691
SC4C6.01, probable phospholipase C, partial CDS, len: >501 aa; similar to e.g. SW:PHLN_PSEAE (EMBL:M59304), plcN, Pseudomonas aeruginosa non-hemolytic phospholipase C precursor (692 aa), fasta scores; opt: 1073 z-score: 1149.1 E(): 0, 44.7% identity in 524 aa overlap; SC6G3.07, probable phospholipase C, partial CDS, len: >221 aa; similar to e.g. SW:PHLN_PSEAE (EMBL:M59304), plcN, Pseudomonas aeruginosa non-hemolytic phospholipase C precursor (692 aa), fasta scores; opt: 853 z-score: 1021.1 E(): 0, 51.3% identity in 232 aa overlap. Continues in cosmid 4C6 (EMBL:AL079355) as SC4C6.01.
     
  0.900
SCO5859
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
  
    0.873
SCO1478
Putative DNA-directed RNA polymerase omega chain; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).
  
   0.742
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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