STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Cooccurrence
Coexpression
Experiments
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[Homology]
Score
SCO5871Putative turgor pressure sensor; SC2E9.12, kdpD, two-component sensor/protein kinase, len: 848 aa; similar to Escherichia coli turgor pressure sensor KDPD_ECOLI P21865 sensor protein kdpD (ec 2.7.3.-) (894 aa), fasta scores; opt: 997 z-score: 1347.4 E(): 0, 34.8% identity in 877 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and Pfam match to entry signal PF00512, Signal C terminal domain, score 184.57. Contains possible hydrophobic membrane spanning regions. (848 aa)    
Predicted Functional Partners:
SCO5872
Putative turgor pressure regulator; SC2E9.13, kdpE, two-component trascriptional regulator, len: 227, similar to E.coli turgor pressure regulator KDPE_ECOLI P21866 kdp operon transcriptional regulatory protein (225 aa), fasta scores; opt: 752 z-score: 1090.9 E(): 0, 51.1% identity in 225 aa overlap. Contains Pfam match to entry trans_reg_C PF00486, Transcriptional regulatory proteins, C terminal, score 96.22.
 
 0.999
SCO3718
Putative cation transport system component; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane.
 
  
 0.979
SCO3716
Putative cation transport system component; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
 
  
 0.973
SCO3717
Putative cation transport system component; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
 
  
 0.964
SCO5873
Hypothetical protein SC2E9.14; SC2E9.14, unknown, len: 154 aa; similar to Mycobacterium tuberculosis hypothetical protein TR:O07196 (EMBL:Z96072) MTCY05A6.15C (122 aa), fasta scores; opt: 299 z-score: 502.1 E(): 9.1e-21, 41.0% identity in 117 aa overlap.
     
 0.879
SCO5874
SC2E9.15, putative membrane protein, len: 272 aa; similar to Mycobacterium tuberculosis hypothetical protein TR:O07195 (EMBL:Z96072) MTCY05A6.14C (223 aa), fasta scores; opt: 212 z-score: 285.5 E(): 1.1e-08, 23.5% identity in 247 aa overlap. Contains possible hydrophobic membrane spanning regions.
       0.875
SCO5870
SC2E9.11, probable ABC-transporter ATP binding protein, len: 230 aa; highly similar to many eg. Y796_METJA Q58206 hypothetical abc transporter atp-binding protein (235 aa), fasta scores; opt: 666 z-score: 870.6 E(): 0, 43.8% identity in 226 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00211 ABC transporters family signature and Pfam match to entry ABC_tran PF00005, ABC transporters, score 54.33.
       0.765
SCO7075
SC3A4.01, two component response regulator protein, len: 230 aa. Highly similar to Pseudomonas syringae (pv. tomato) SW:COPR_PSESM (EMBL:L05176) transcriptional activator of copper resistance operon, CopR (227 aa) fasta scores, opt: 549 z-score: 653.7 E(): 5.9e-29 41.8% identity in 225 aa overlap and Synechococcus sp. (strain PCC 7942) (Anacystis nidulans R2)SW:SPHR_SYNP7(EMBL; D13172) response regulator of alkaline phosphatase, SphR (257 aa) fasta scores, opt: 554 z-score: 658.8 E(): 3.1e-29 40.8% identity in 233 aa overlap. Also similar to Streptomyces coelicolor SCD84.24c (248 aa), [...]
  
 
 0.750
SCO5867
Hypothetical protein SC2E9.08; SC2E9.08, unknown, len: 194 aa.
       0.683
SCO5868
Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
       0.683
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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