STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO5876Potassium uptake protein; Part of a potassium transport system. (223 aa)    
Predicted Functional Partners:
SCO5875
SC2E9.16c, possible potassium uptake protein; len: 226 aa; similar to many homologs of trkA eg. Mycobacterium tuberculosis TR:O07194 (EMBL:Z96072) MTCY05A6.13 (220 aa), fasta scores; opt: 870 z-score: 1486.1 E(): 0, 58.8% identity in 216 aa overlap. Also similar to upstream ORF SC2E9.17c, trkA, (E(): 1.8e-05, 22.6% identity in 212 aa overlap).
 
  
0.934
SCO5879
Acyl-coa dehydrogenase RedW; Involved in the biosynthesis of undecylprodigiosin. Catalyzes the desaturation of the L-prolyl-[prolyl-carrier protein] to yield 1H-pyrrole-2-carbonyl- [prolyl-carrier protein].
     
 0.841
SCO5900
SC10A5.05, probable membrane protein, len: 691; high ly similar to M. tuberculosis putative membrane protein TR: O07192 (EMBL:Z96072) MTCY05A6.11C (647 aa), fasta scores; o pt: 1980 z-score: 3557.6 E(): 0, 62.7% identity in 659 aa o verlap and weakly similar to many transport proteins eg. PR OY_SALTY P37460 proline-specific permease proy from Salmone lla typhimurium (456 aa), fasta scores; opt: 169 z-score: 1 82.8 E(): 0.0055, 24.2% identity in 355 aa overlap.
 
   
 0.838
SCO5878
SC2E9.19, redX, polyketide synthase with two beta-ketoacyl synthase domains, len: 982 aa; similar to many eg. ERY3_SACER Q03133 erythronolide synthase, modules 5 and 6 (3170 aa), fasta scores; opt: 649 z-score: 586.3 E(): 1.9e-25, 29.2% identity in 1029 aa overlap. Contains 2 x Pfam match to entry ketoacyl-synt PF00109, Beta-ketoacyl synthases, scores 52.40 and 310.80; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
     
 0.837
SCO5877
Transcriptional regulator RedD; The RedD protein is probably one of several delicately balanced regulatory factors that contribute to the control of the biosynthesis of the antibiotic undecylprodigiosin (Red) in S.coelicolor.
     
 0.697
SCO5873
Hypothetical protein SC2E9.14; SC2E9.14, unknown, len: 154 aa; similar to Mycobacterium tuberculosis hypothetical protein TR:O07196 (EMBL:Z96072) MTCY05A6.15C (122 aa), fasta scores; opt: 299 z-score: 502.1 E(): 9.1e-21, 41.0% identity in 117 aa overlap.
  
     0.683
SCO1472
SCL6.29c, conserved hypothetical Sun-family protein, len: 475 aa; similar to SW:SUN_BACSU (EMBL:Y13937) Bacillus subtilis sun protein, 447 aa; fasta scores: opt: 637 z-score: 711.7 E(): 3.2e-32; 32.0% identity in 472 aa overlap. Contains Pfam match to entry PF01029 NusB, NusB family and to entry PF01189 Nol1_Nop2_Sun, NOL1/NOP2/sun family and match to Prosite entry PS01153 NOL1/NOP2/sun family signature; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
  
   0.680
SCO5201
2SC3B6.25, moaE-like protein, len: 152 aa; similar to SW:MOAE_ECOLI (EMBL:X70420) Escherichia coli molybdopterin [mpt] converting factor, subunit 2 MoaE, 149 aa; fasta scores: opt: 255 z-score: 317.2 E(): 3.3e-10; 33.3% identity in 129 aa overlap.
   
    0.603
SCO2958
SCE59.17c, possible transcriptional regulator, len: 395 aa; similar to TR:P95217 (EMBL:Z86089) Mycobacterium tuberculosis hypothetical 40.7 kD protein MCTY0A4.04c, 381 aa; fasta scores: opt: 1224 z-score: 1335.3 E(): 0; 52.3% identity in 377 aa overlap and C-terminal region similar to SW:CUTR_STRCO (EMBL:X58793) Streptomyces coelicolor transcriptional regulatory protein CutR, 217 aa; fasta scores: opt: 130 z-score: 151.1 E(): 0.53; 30.3% identity in 132 aa overlap. Contains Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal.
 
    0.578
SCO6385
SC3C8.04c, probable integral membrane protein, len: 644 aa; similar to hypothetical proteins e.g. M. tuberculosis TR:O07192 (EMBL:Z96072) MTCY05A6.11C (647 aa), fassta scores; opt: 916 z-score: 1168.8 E(): 0, 35.3% identity in 666 aa overlap. Also similar to S.coelicolor SC10A5.05 (E():0, 34.8% identity in 669 aa overlap).
 
   
 0.567
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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