STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO5879Acyl-coa dehydrogenase RedW; Involved in the biosynthesis of undecylprodigiosin. Catalyzes the desaturation of the L-prolyl-[prolyl-carrier protein] to yield 1H-pyrrole-2-carbonyl- [prolyl-carrier protein]. (391 aa)    
Predicted Functional Partners:
SCO5878
SC2E9.19, redX, polyketide synthase with two beta-ketoacyl synthase domains, len: 982 aa; similar to many eg. ERY3_SACER Q03133 erythronolide synthase, modules 5 and 6 (3170 aa), fasta scores; opt: 649 z-score: 586.3 E(): 1.9e-25, 29.2% identity in 1029 aa overlap. Contains 2 x Pfam match to entry ketoacyl-synt PF00109, Beta-ketoacyl synthases, scores 52.40 and 310.80; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
    
 0.995
SCO5891
Putative peptide synthase; Involved in the biosynthesis of undecylprodigiosin. Catalyzes the conversion of L- proline to L-prolyl-AMP and the transfer of the L-prolyl group to acyl carrier protein RedO ; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 
 0.978
SCO5889
Hypothetical protein SC3F7.09; SC3F7.09, redO, unknown, len: 87 aa.
    
 0.949
SCO5880
SC2E9.21, redY, unknown function, len: 106.
     
 0.915
SCO1081
SCG22.27c, probable electron transfer flavoprotein, alpha subunit, len: 320 aa; similar to SW:ETFA_PARDE (EMBL:L14864) Paracoccus denitrificans electron transfer flavoprotein, alpha subunit EftA, 307 aa; fasta scores: opt: 673 z-score: 707.8 E(): 6e-32; 44.3% identity in 316 aa overlap and to SW:ETFA_MYCTU (EMBL:AL021287) Mycobacterium tuberculosis electron transfer flavoprotein alpha-subunit EftA or MTV012.43c, 318 aa; fasta scores: opt: 1161 z-score: 1212.8 E(): 0; 59.4% identity in 323 aa overlap. Contains Pfam match to entry PF00766 ETF_alpha, Electron transfer flavoprotein alpha s [...]
 
 0.884
SCO1082
SCG22.28c, probable electron transfer flavoprotein, beta subunit, len: 262 aa; similar to SW:ETFB_MYCTU (EMBL:AL021287) Mycobacterium tuberculosis putative electron transfer flavoprotein, beta subunit FixA or MTV012.44c, 266 aa; fasta scores: opt: 860 z-score: 939.3 E(): 0; 52.5% identity in 263 aa overlap. Contains Pfam match to entry PF01012 ETF_beta, Electron transfer flavoprotein beta subunit.
 
 
 0.868
SCO5876
Potassium uptake protein; Part of a potassium transport system.
     
 0.841
SCO5877
Transcriptional regulator RedD; The RedD protein is probably one of several delicately balanced regulatory factors that contribute to the control of the biosynthesis of the antibiotic undecylprodigiosin (Red) in S.coelicolor.
     
 0.786
SCO6026
SC1C3.14c, probable fatty acid oxidation complex alpha-subunit, similar to many e.g. FADB_ECOLI (729 aa), fasta scores; opt: 782 z-score: 863.1 E(): 0, 29.8% identity in671 aa overlap. Contains Pfam match to entry ECH PF00378, Enoyl-CoA hydratase/isomerase, score 49.78.
  
 0.716
SCO6732
SC5F2A.15, possible fatty acid oxidative multifunctional enzyme, len: 726aa; similar to SW:FAOB_PSEFR fatty oxidation complex alpha subunit from Pseudomonas fragi (715 aa) fasta scores; opt: 1174, z-score: 1211.3, E(): 0, (33.2% identity in 717 aa overlap). Also similar to TR:O53872 (EMBL:AL022004) hypothetical protein from Mycobacterium tuberculosis (720 aa) fasta scores; opt: 3034, z-score: 3128.4, E(): 0, (64.3% identity in 717 aa overlap). Also similar to SC6A5.38 (EMBL:AL049485) possible fatty oxidation protein from Streptomyces coelicolor (733 aa) fasta scores; opt: 4069, z-score [...]
  
 0.716
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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