STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SCO5891Putative peptide synthase; Involved in the biosynthesis of undecylprodigiosin. Catalyzes the conversion of L- proline to L-prolyl-AMP and the transfer of the L-prolyl group to acyl carrier protein RedO ; Belongs to the ATP-dependent AMP-binding enzyme family. (532 aa)    
Predicted Functional Partners:
SCO5892
SC3F7.12, redL, probable polyketide synthase, len: 2297 aa; contains 3 modules: N-terminus (start to approx. aa 700) similar to eg. N-terminus of TR:Q50857 (EMBL:U24657) saframycin mx1 synthetase B from Myxococcus xanthus (1770 aa) (fasta scores; E(): 0, 45.0% identity in 691 aa overlap), contains Pfam match to AMP-binding PF00501, AMP-binding enzymes, score 166.66; central module (approx aa 795 to 1800) similar to eg. TR:G2317861 (EMBL:U78289) Streptomyces fradiae tylactone synthase module 3 (1864 aa) (E(): 0, 39.9% identity in 1125 aa overlap), contains PS00606 Beta-ketoacyl synthase [...]
 0.990
SCO5879
Acyl-coa dehydrogenase RedW; Involved in the biosynthesis of undecylprodigiosin. Catalyzes the desaturation of the L-prolyl-[prolyl-carrier protein] to yield 1H-pyrrole-2-carbonyl- [prolyl-carrier protein].
  
 
 0.978
SCO5895
SC3F7.15, redI, possible methyltransferase, len: 362 aa; weakly similar to several e.g. Streptomyces griseus TR:P72450 (EMBL:X95596) methyltransferase (242 aa), fasta scores; opt: 130 z-score: 204.9 E(): 0.00032, 27.6% identity in 192 aa overlap.
 
   
 0.964
SCO5889
Hypothetical protein SC3F7.09; SC3F7.09, redO, unknown, len: 87 aa.
  
 0.963
SCO5894
Thioesterase; SC3F7.14, redJ, probable thioesterase, len: 280 aa; similar to many e.g. TR:Q00442 (EMBL:X60379) erythomycin A biosynthesis thioesterase (EC 3.1.-.-.) from Saccharopolyspora erythraea (Streptomyces erythraeus) (247 aa), fasta scores; opt: 451 z-score: 472.9 E(): 3.8e-19, 38.0% identity in 237 aa overlap.
 
  
 0.954
SCO1273
2SCG18.20c, probable reductase, len: 372 aa; similar to C-terminal domain of SW:HETM_ANASP (EMBL:L22883) Anabaena sp. polyketide synthase HetM, 506 aa; fasta scores: opt: 333 z-score: 389.0 E(): 3.5e-14; 35.7% identity in 395 aa overlap and to Streptomyces coelicolor 2SCG18.32c, 373 aa; fasta scores: opt: 241 z-score: 242.2 E(): 6.9e-08; 27.0% identity in 330 aa overlap. Contains TTA leucine codon, possible target for bldA regulation.
  
 0.941
SCO6827
SC4A9.04c, polyketide synthase, len: 2358 aa. Highly similar to many including: Stigmatella aurantiaca TR:AAF19813(EMBL:AF188287) polyketide synthase, MtAE, found within the Myxothiazol biosynthetic gene cluster (1947 aa), fasta scores opt: 2671 z-score: 2436.5 E():0 35.8% identity in 1770 aa overlap and Mycobacterium tuberculosis SW:PPSA_MYCTU(EMBL:Z74697) phenolpthiocerol synthesis polyketide synthase gene, PpsA (1876 aa), fasta scores opt: 2221 z-score: 2025.5 E(): 0 33.6% identity in 1761 aa overlap. Contains Prosite hits to PS00606 Beta-ketoacyl synthases active site and 2xPS00012 [...]
 0.928
SCO6273
SC2C4.03c, probable type I polyketide synthase, len: 2152 aa; N-terminal domain almost identical to TR:Q9L8J0 (EMBL:AF202898) Streptomyces coelicolor A3(2) type I polyketide synthase (fragment), 720 aa; fasta scores: opt: 4356 z-score: 4494.6 E(): 0; 93.8% identity in 721 aa overlap and C-terminal domain similar to SW:HETM_ANASP (EMBL:L22883) Anabaena sp. polyketide synthase HetM, 506 aa; blastp scores: Score= 761 (267.9 bits), Expect= 2.2e-74, Sum P(2)= 2.2e-74; Identities= 184/491 (37%), Positives= 278/491 (56%). Also highly similar, in this same cosmid, to the N-terminal region of S [...]
 0.927
SCO3230
SCE63.03c, cdaPSI, CDA peptide synthetase I, len: 7463 aa; part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This CDS encodes a subunit of this enzyme and is suspected to be responsible for the incorperation of the first 6 amino acids into the antibiotic structure. This ORF overlaps the downstream (cdaPSII) ORF by one base indicating possible translational coupling. Contains eight separate Pfam matches to entry PF00668 [...]
 
 
0.915
SCO0492
SCF34.11c, probable peptide synthetase, len: 3643 aa; similar to parts of many antibiotic peptide synthetases e.g. the C-terminal half of TR:Q9Z4X6 (EMBL:AL035640) Streptomyces coelicolor CDA peptide synthetase I (7463 aa), fasta scores; opt: 1948 z-score: 1929.3 E(): 0, 33.7% identity in 3723 aa overlap. Also similar to parts of putative peptide synthetases from the exochelin biosynthesis locus of Mycobacterium smegmatis TR:O87314 (EMBL:AF027770), FxbC, putative peptide synthetase (4976 aa) (42.3% identity in 3756 aa overlap). Contains 3 Pfam matches to entry PF00550 pp-binding, Phosp [...]
 
 
0.901
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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