Export your current network:
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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
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a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SCO3231 | SCO3232 | gene:17760849 | gene:17760850 | SCE63.02c, cdaPS2, CDA peptide synthetase II, len: 3670 aa; part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This CDS encodes a subunit of this enzyme and is suspected to be responsible for the addition of 3 amino acids to the peptide antibiotic. This ORF overlaps the upstream (cdaPSI) and downstream (cdaPSIII) ORFs by one base indicating possible translational coupling of all three. Contains four separate Pfam matche [...] | SCE63.01, partial CDS, cdaPS3, CDA peptide synthetase III, len: >332 aa; Constitutes the N-terminus of cdaPS3, CDA peptide synthetase III, part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This partial CDS encodes the N-terminus of a subunit of this enzyme suspected to be responsible for the addition of 2 amino acids to the peptide antibiotic. This ORF overlaps the upstream (cdaPSII) by one base indicating possible tra [...] | 0.994 |
| SCO3231 | SCO5887 | gene:17760849 | gene:17763547 | SCE63.02c, cdaPS2, CDA peptide synthetase II, len: 3670 aa; part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This CDS encodes a subunit of this enzyme and is suspected to be responsible for the addition of 3 amino acids to the peptide antibiotic. This ORF overlaps the upstream (cdaPSI) and downstream (cdaPSIII) ORFs by one base indicating possible translational coupling of all three. Contains four separate Pfam matche [...] | SC3F7.07c, redQ, probable acyl carrier protein, len; 81 aa; similar to several eg. ACP_SYNY3 P20804 acyl carrier protein (acp) from Synechocystis (77 aa),fasta scores; opt: 153 z-score: 256.6 E(): 4.2e-07, 34.7% identity in 72 aa overlap. | 0.662 |
| SCO3231 | SCO5891 | gene:17760849 | gene:17763551 | SCE63.02c, cdaPS2, CDA peptide synthetase II, len: 3670 aa; part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This CDS encodes a subunit of this enzyme and is suspected to be responsible for the addition of 3 amino acids to the peptide antibiotic. This ORF overlaps the upstream (cdaPSI) and downstream (cdaPSIII) ORFs by one base indicating possible translational coupling of all three. Contains four separate Pfam matche [...] | Putative peptide synthase; Involved in the biosynthesis of undecylprodigiosin. Catalyzes the conversion of L- proline to L-prolyl-AMP and the transfer of the L-prolyl group to acyl carrier protein RedO ; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.554 |
| SCO3231 | SCO5892 | gene:17760849 | gene:17763552 | SCE63.02c, cdaPS2, CDA peptide synthetase II, len: 3670 aa; part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This CDS encodes a subunit of this enzyme and is suspected to be responsible for the addition of 3 amino acids to the peptide antibiotic. This ORF overlaps the upstream (cdaPSI) and downstream (cdaPSIII) ORFs by one base indicating possible translational coupling of all three. Contains four separate Pfam matche [...] | SC3F7.12, redL, probable polyketide synthase, len: 2297 aa; contains 3 modules: N-terminus (start to approx. aa 700) similar to eg. N-terminus of TR:Q50857 (EMBL:U24657) saframycin mx1 synthetase B from Myxococcus xanthus (1770 aa) (fasta scores; E(): 0, 45.0% identity in 691 aa overlap), contains Pfam match to AMP-binding PF00501, AMP-binding enzymes, score 166.66; central module (approx aa 795 to 1800) similar to eg. TR:G2317861 (EMBL:U78289) Streptomyces fradiae tylactone synthase module 3 (1864 aa) (E(): 0, 39.9% identity in 1125 aa overlap), contains PS00606 Beta-ketoacyl synthase [...] | 0.978 |
| SCO3231 | SCO5894 | gene:17760849 | gene:17763554 | SCE63.02c, cdaPS2, CDA peptide synthetase II, len: 3670 aa; part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This CDS encodes a subunit of this enzyme and is suspected to be responsible for the addition of 3 amino acids to the peptide antibiotic. This ORF overlaps the upstream (cdaPSI) and downstream (cdaPSIII) ORFs by one base indicating possible translational coupling of all three. Contains four separate Pfam matche [...] | Thioesterase; SC3F7.14, redJ, probable thioesterase, len: 280 aa; similar to many e.g. TR:Q00442 (EMBL:X60379) erythomycin A biosynthesis thioesterase (EC 3.1.-.-.) from Saccharopolyspora erythraea (Streptomyces erythraeus) (247 aa), fasta scores; opt: 451 z-score: 472.9 E(): 3.8e-19, 38.0% identity in 237 aa overlap. | 0.947 |
| SCO3231 | SCO6432 | gene:17760849 | gene:17764089 | SCE63.02c, cdaPS2, CDA peptide synthetase II, len: 3670 aa; part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This CDS encodes a subunit of this enzyme and is suspected to be responsible for the addition of 3 amino acids to the peptide antibiotic. This ORF overlaps the upstream (cdaPSI) and downstream (cdaPSIII) ORFs by one base indicating possible translational coupling of all three. Contains four separate Pfam matche [...] | SC1A6.21, probable peptide synthase, len: 1407 aa; similar to many e.g. TR:Q54959 (EMBL:X98690) Streptomyces pristinaespiralis Pristinamycin I synthase 2 (2591 aa), fasta scores; opt: 743 z-score: 754.8 E(): 0, 33.1% identity in1298 aa overlap. Contains PS00455 Putative AMP-binding domain signature, PS00012 Phosphopantetheine attachment site, PS00120 Lipases, serine active site and Pfam match to entry AMP-binding PF00501, AMP-binding enzymes, score 430.73. | 0.921 |
| SCO3231 | SCO7682 | gene:17760849 | gene:17765342 | SCE63.02c, cdaPS2, CDA peptide synthetase II, len: 3670 aa; part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This CDS encodes a subunit of this enzyme and is suspected to be responsible for the addition of 3 amino acids to the peptide antibiotic. This ORF overlaps the upstream (cdaPSI) and downstream (cdaPSIII) ORFs by one base indicating possible translational coupling of all three. Contains four separate Pfam matche [...] | SC4C2.17, probable non-ribosomal peptide synthase, len: 2229 aa; similar to TR:AAG02364 (EMBL:AF210249) Streptomyces verticillus peptide synthetase NRPS2-1 BlmIV, 2626 aa; fasta scores: opt: 2485 z-score: 2429.3 E(): 0; 37.9% identity in 2203 aa overlap, to SW:HMP2_YEREN (EMBL:L18881) Yersinia enterocolitica high-molecular-weight protein 2 Irp2, 2035 aa; fasta scores: opt: 2251 z-score: 2201.3 E(): 0; 33.3% identity in 2022 aa overlap to TR:CAA18919 (EMBL:AL023496) Streptomyces coelicolor probable peptide synthase SC1A6.21, 1407 aa; fasta scores: opt: 1764 z-score: 1430.4 E(): 0; 40.0% [...] | 0.923 |
| SCO3231 | SCO7683 | gene:17760849 | gene:17765343 | SCE63.02c, cdaPS2, CDA peptide synthetase II, len: 3670 aa; part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This CDS encodes a subunit of this enzyme and is suspected to be responsible for the addition of 3 amino acids to the peptide antibiotic. This ORF overlaps the upstream (cdaPSI) and downstream (cdaPSIII) ORFs by one base indicating possible translational coupling of all three. Contains four separate Pfam matche [...] | SC4C2.18, probable non-ribosomal peptide synthase, len: 1842 aa; similar to C-terminal domain of TR:AAG02364 (EMBL:AF210249) Streptomyces verticillus peptide synthetase NRPS2-1 BlmIV, 2626 aa; fasta scores: opt: 2514 z-score: 2613.8 E(): 0; 40.7% identity in 1287 aa overlap, to TR:Q9RFM7 (EMBL:AF184622) Pseudomonas aeruginosa pyochelin synthetase PchF, 1809 aa; fasta scores: opt: 2279 z-score: 2370.9 E(): 0; 39.7% identity in 1887 aa overlap, to TR:CAA18919 (EMBL:AL023496) Streptomyces coelicolor probable peptide synthase SC1A6.21, 1407 aa; fasta scores: opt: 1826 z-score: 1476.6 E(): [...] | 0.920 |
| SCO3232 | SCO3231 | gene:17760850 | gene:17760849 | SCE63.01, partial CDS, cdaPS3, CDA peptide synthetase III, len: >332 aa; Constitutes the N-terminus of cdaPS3, CDA peptide synthetase III, part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This partial CDS encodes the N-terminus of a subunit of this enzyme suspected to be responsible for the addition of 2 amino acids to the peptide antibiotic. This ORF overlaps the upstream (cdaPSII) by one base indicating possible tra [...] | SCE63.02c, cdaPS2, CDA peptide synthetase II, len: 3670 aa; part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This CDS encodes a subunit of this enzyme and is suspected to be responsible for the addition of 3 amino acids to the peptide antibiotic. This ORF overlaps the upstream (cdaPSI) and downstream (cdaPSIII) ORFs by one base indicating possible translational coupling of all three. Contains four separate Pfam matche [...] | 0.994 |
| SCO3232 | SCO5887 | gene:17760850 | gene:17763547 | SCE63.01, partial CDS, cdaPS3, CDA peptide synthetase III, len: >332 aa; Constitutes the N-terminus of cdaPS3, CDA peptide synthetase III, part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This partial CDS encodes the N-terminus of a subunit of this enzyme suspected to be responsible for the addition of 2 amino acids to the peptide antibiotic. This ORF overlaps the upstream (cdaPSII) by one base indicating possible tra [...] | SC3F7.07c, redQ, probable acyl carrier protein, len; 81 aa; similar to several eg. ACP_SYNY3 P20804 acyl carrier protein (acp) from Synechocystis (77 aa),fasta scores; opt: 153 z-score: 256.6 E(): 4.2e-07, 34.7% identity in 72 aa overlap. | 0.741 |
| SCO3232 | SCO5891 | gene:17760850 | gene:17763551 | SCE63.01, partial CDS, cdaPS3, CDA peptide synthetase III, len: >332 aa; Constitutes the N-terminus of cdaPS3, CDA peptide synthetase III, part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This partial CDS encodes the N-terminus of a subunit of this enzyme suspected to be responsible for the addition of 2 amino acids to the peptide antibiotic. This ORF overlaps the upstream (cdaPSII) by one base indicating possible tra [...] | Putative peptide synthase; Involved in the biosynthesis of undecylprodigiosin. Catalyzes the conversion of L- proline to L-prolyl-AMP and the transfer of the L-prolyl group to acyl carrier protein RedO ; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.563 |
| SCO3232 | SCO5892 | gene:17760850 | gene:17763552 | SCE63.01, partial CDS, cdaPS3, CDA peptide synthetase III, len: >332 aa; Constitutes the N-terminus of cdaPS3, CDA peptide synthetase III, part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This partial CDS encodes the N-terminus of a subunit of this enzyme suspected to be responsible for the addition of 2 amino acids to the peptide antibiotic. This ORF overlaps the upstream (cdaPSII) by one base indicating possible tra [...] | SC3F7.12, redL, probable polyketide synthase, len: 2297 aa; contains 3 modules: N-terminus (start to approx. aa 700) similar to eg. N-terminus of TR:Q50857 (EMBL:U24657) saframycin mx1 synthetase B from Myxococcus xanthus (1770 aa) (fasta scores; E(): 0, 45.0% identity in 691 aa overlap), contains Pfam match to AMP-binding PF00501, AMP-binding enzymes, score 166.66; central module (approx aa 795 to 1800) similar to eg. TR:G2317861 (EMBL:U78289) Streptomyces fradiae tylactone synthase module 3 (1864 aa) (E(): 0, 39.9% identity in 1125 aa overlap), contains PS00606 Beta-ketoacyl synthase [...] | 0.991 |
| SCO3232 | SCO5894 | gene:17760850 | gene:17763554 | SCE63.01, partial CDS, cdaPS3, CDA peptide synthetase III, len: >332 aa; Constitutes the N-terminus of cdaPS3, CDA peptide synthetase III, part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This partial CDS encodes the N-terminus of a subunit of this enzyme suspected to be responsible for the addition of 2 amino acids to the peptide antibiotic. This ORF overlaps the upstream (cdaPSII) by one base indicating possible tra [...] | Thioesterase; SC3F7.14, redJ, probable thioesterase, len: 280 aa; similar to many e.g. TR:Q00442 (EMBL:X60379) erythomycin A biosynthesis thioesterase (EC 3.1.-.-.) from Saccharopolyspora erythraea (Streptomyces erythraeus) (247 aa), fasta scores; opt: 451 z-score: 472.9 E(): 3.8e-19, 38.0% identity in 237 aa overlap. | 0.951 |
| SCO3232 | SCO6432 | gene:17760850 | gene:17764089 | SCE63.01, partial CDS, cdaPS3, CDA peptide synthetase III, len: >332 aa; Constitutes the N-terminus of cdaPS3, CDA peptide synthetase III, part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This partial CDS encodes the N-terminus of a subunit of this enzyme suspected to be responsible for the addition of 2 amino acids to the peptide antibiotic. This ORF overlaps the upstream (cdaPSII) by one base indicating possible tra [...] | SC1A6.21, probable peptide synthase, len: 1407 aa; similar to many e.g. TR:Q54959 (EMBL:X98690) Streptomyces pristinaespiralis Pristinamycin I synthase 2 (2591 aa), fasta scores; opt: 743 z-score: 754.8 E(): 0, 33.1% identity in1298 aa overlap. Contains PS00455 Putative AMP-binding domain signature, PS00012 Phosphopantetheine attachment site, PS00120 Lipases, serine active site and Pfam match to entry AMP-binding PF00501, AMP-binding enzymes, score 430.73. | 0.649 |
| SCO3232 | SCO7682 | gene:17760850 | gene:17765342 | SCE63.01, partial CDS, cdaPS3, CDA peptide synthetase III, len: >332 aa; Constitutes the N-terminus of cdaPS3, CDA peptide synthetase III, part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This partial CDS encodes the N-terminus of a subunit of this enzyme suspected to be responsible for the addition of 2 amino acids to the peptide antibiotic. This ORF overlaps the upstream (cdaPSII) by one base indicating possible tra [...] | SC4C2.17, probable non-ribosomal peptide synthase, len: 2229 aa; similar to TR:AAG02364 (EMBL:AF210249) Streptomyces verticillus peptide synthetase NRPS2-1 BlmIV, 2626 aa; fasta scores: opt: 2485 z-score: 2429.3 E(): 0; 37.9% identity in 2203 aa overlap, to SW:HMP2_YEREN (EMBL:L18881) Yersinia enterocolitica high-molecular-weight protein 2 Irp2, 2035 aa; fasta scores: opt: 2251 z-score: 2201.3 E(): 0; 33.3% identity in 2022 aa overlap to TR:CAA18919 (EMBL:AL023496) Streptomyces coelicolor probable peptide synthase SC1A6.21, 1407 aa; fasta scores: opt: 1764 z-score: 1430.4 E(): 0; 40.0% [...] | 0.982 |
| SCO3232 | SCO7683 | gene:17760850 | gene:17765343 | SCE63.01, partial CDS, cdaPS3, CDA peptide synthetase III, len: >332 aa; Constitutes the N-terminus of cdaPS3, CDA peptide synthetase III, part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This partial CDS encodes the N-terminus of a subunit of this enzyme suspected to be responsible for the addition of 2 amino acids to the peptide antibiotic. This ORF overlaps the upstream (cdaPSII) by one base indicating possible tra [...] | SC4C2.18, probable non-ribosomal peptide synthase, len: 1842 aa; similar to C-terminal domain of TR:AAG02364 (EMBL:AF210249) Streptomyces verticillus peptide synthetase NRPS2-1 BlmIV, 2626 aa; fasta scores: opt: 2514 z-score: 2613.8 E(): 0; 40.7% identity in 1287 aa overlap, to TR:Q9RFM7 (EMBL:AF184622) Pseudomonas aeruginosa pyochelin synthetase PchF, 1809 aa; fasta scores: opt: 2279 z-score: 2370.9 E(): 0; 39.7% identity in 1887 aa overlap, to TR:CAA18919 (EMBL:AL023496) Streptomyces coelicolor probable peptide synthase SC1A6.21, 1407 aa; fasta scores: opt: 1826 z-score: 1476.6 E(): [...] | 0.648 |
| SCO5886 | SCO5887 | gene:17763546 | gene:17763547 | 3-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. | SC3F7.07c, redQ, probable acyl carrier protein, len; 81 aa; similar to several eg. ACP_SYNY3 P20804 acyl carrier protein (acp) from Synechocystis (77 aa),fasta scores; opt: 153 z-score: 256.6 E(): 4.2e-07, 34.7% identity in 72 aa overlap. | 0.945 |
| SCO5886 | SCO5888 | gene:17763546 | gene:17763548 | 3-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. | 3-oxoacyl-[acyl-carrier-protein] synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. | 0.969 |
| SCO5886 | SCO5891 | gene:17763546 | gene:17763551 | 3-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. | Putative peptide synthase; Involved in the biosynthesis of undecylprodigiosin. Catalyzes the conversion of L- proline to L-prolyl-AMP and the transfer of the L-prolyl group to acyl carrier protein RedO ; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.631 |
| SCO5886 | SCO5892 | gene:17763546 | gene:17763552 | 3-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. | SC3F7.12, redL, probable polyketide synthase, len: 2297 aa; contains 3 modules: N-terminus (start to approx. aa 700) similar to eg. N-terminus of TR:Q50857 (EMBL:U24657) saframycin mx1 synthetase B from Myxococcus xanthus (1770 aa) (fasta scores; E(): 0, 45.0% identity in 691 aa overlap), contains Pfam match to AMP-binding PF00501, AMP-binding enzymes, score 166.66; central module (approx aa 795 to 1800) similar to eg. TR:G2317861 (EMBL:U78289) Streptomyces fradiae tylactone synthase module 3 (1864 aa) (E(): 0, 39.9% identity in 1125 aa overlap), contains PS00606 Beta-ketoacyl synthase [...] | 0.622 |
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