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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO5895SC3F7.15, redI, possible methyltransferase, len: 362 aa; weakly similar to several e.g. Streptomyces griseus TR:P72450 (EMBL:X95596) methyltransferase (242 aa), fasta scores; opt: 130 z-score: 204.9 E(): 0.00032, 27.6% identity in 192 aa overlap. (362 aa)    
Predicted Functional Partners:
SCO5896
SC10A5.01, redH, probable phosphoenolpyruvate-utilizing enzyme, partial CDS, len: >95 aa; overlaps and extends ORF from neighbouring cosmid SC3F7.16; similar to many eg. PPSA_STAMA P46893 probable phosphoenolpyruvate synthase (834 aa), fasta scores; opt: 215 z-score: 351.4 E(): 2.3e-12, 47.8% identity in 69 aa overlap; SC3F7.16, probable phosphoenolpyruvate-utilizing enzyme, partial CDS, len: >872 aa; similar to many eg. PPSA_STAMA P46893 probable phosphoenolpyruvate synthase from Staphylothermus marinus (834 aa), fasta scores; opt: 392 z-score: 614.9 E(): 4.7e-27, 33.0% identity in 30 [...]
 
  
 0.995
SCO5892
SC3F7.12, redL, probable polyketide synthase, len: 2297 aa; contains 3 modules: N-terminus (start to approx. aa 700) similar to eg. N-terminus of TR:Q50857 (EMBL:U24657) saframycin mx1 synthetase B from Myxococcus xanthus (1770 aa) (fasta scores; E(): 0, 45.0% identity in 691 aa overlap), contains Pfam match to AMP-binding PF00501, AMP-binding enzymes, score 166.66; central module (approx aa 795 to 1800) similar to eg. TR:G2317861 (EMBL:U78289) Streptomyces fradiae tylactone synthase module 3 (1864 aa) (E(): 0, 39.9% identity in 1125 aa overlap), contains PS00606 Beta-ketoacyl synthase [...]
 
   
 0.976
SCO5882
SC3F7.02c, redV, function unknown, len: 395 aa.
  
 
 0.971
SCO5891
Putative peptide synthase; Involved in the biosynthesis of undecylprodigiosin. Catalyzes the conversion of L- proline to L-prolyl-AMP and the transfer of the L-prolyl group to acyl carrier protein RedO ; Belongs to the ATP-dependent AMP-binding enzyme family.
 
   
 0.964
SCO5893
Oxidoreductase; SC3F7.13, redK, probable oxidoreductase, len: 347 aa; similar to many eukaryotic steroid dehydrogenases eg. TR:Q62878 (EMBL:L17138) 3 hydroxysteroid dehydrogenase from Rattus norvegicus (373 aa), fasta scores; opt: 103 z-score: 378.9 E(): 6.6e-14, 30.4% identity in 355 aa overlap; and to Mycobacterium tuberculosis putative dehydrogenase TR:O06373 (EMBL:Z95436) MTCY15C10.18 (314 aa), fasta scores; opt: 204 z-score: 417.9 E(): 4.4e-16, 27.7% identity in 339 aa overlap.
 
   
 0.952
SCO5897
Putative oxidase; SC10A5.02, redG, probable oxidase, len: 395 aa; similar in N- terminus to many diverse oxidases e.g. TR:P95483 (EMBL:U7449 3) aminopyrrolnitrin oxidase PrnD from Pseudomonas fluorescens (363 aa), fasta scores; opt: 349 z-score: 372.1 E(): 1. 6e-13, 33.3% identity in 165 aa overlap.
 
   
 0.903
SCO5890
SC3F7.10, redN, putative 8-amino-7-oxononanoate synthase, len: 640 aa; similar to many diverse transferases eg. BIOF_BACSH P22806 8-amino-7-oxononanoate synthase (389 aa), fasta scores; opt: 926 z-score: 888.4 E(): 0, 42.1% identity in 361 aa overlap. Also simlar to SC3F7.12 from aa 1700 to end (E(): 3.6e-15, 31.9% identity in 630 aa overlap). Contains Pfam match to entry aminotran_2 PF00222, Aminotransferases class-II, score 292.92 in C-terminus.
 
   
 0.876
SCO5883
Hypothetical protein SC3F7.03c; SC3F7.03c, redU, unknown, len: 261 aa; Belongs to the P-Pant transferase superfamily.
 
   
 0.858
SCO5894
Thioesterase; SC3F7.14, redJ, probable thioesterase, len: 280 aa; similar to many e.g. TR:Q00442 (EMBL:X60379) erythomycin A biosynthesis thioesterase (EC 3.1.-.-.) from Saccharopolyspora erythraea (Streptomyces erythraeus) (247 aa), fasta scores; opt: 451 z-score: 472.9 E(): 3.8e-19, 38.0% identity in 237 aa overlap.
 
   
 0.850
SCO5878
SC2E9.19, redX, polyketide synthase with two beta-ketoacyl synthase domains, len: 982 aa; similar to many eg. ERY3_SACER Q03133 erythronolide synthase, modules 5 and 6 (3170 aa), fasta scores; opt: 649 z-score: 586.3 E(): 1.9e-25, 29.2% identity in 1029 aa overlap. Contains 2 x Pfam match to entry ketoacyl-synt PF00109, Beta-ketoacyl synthases, scores 52.40 and 310.80; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
 
   
 0.805
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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