STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO5914SC10A5.19c, probable transcriptional regulator, len: 330 aa; similar to many membres of the LysR family e.g. MPR R_STRCO P43160 small neutral protease regulatory protein (316 aa), fasta cores; opt: 510 z-score: 581.6 E(): 3.4e-25, 35.8% identity in 324 aa overlap. Contains PS00044 Bacterial regulatory proteins, lysR family signature. (330 aa)    
Predicted Functional Partners:
SCO2734
SCC57A.05, possible LysR-family transcriptional regulator, len: 344 aa. Similar to several other regulators including: Streptomyces lividans TR:Q9X9S5 (EMBL:Y18818) transcriptional regulator (LysR-family), found adjacent to the actinorhodin biosynthetic cluster (307 aa), fasta scores opt: 275 z-score: 303.4 E(): 1.6e-09 31.3% identity in 336 aa overlap. Also similar to Streptomyces coelicolor regulators: TR:Q9X9U9 (EMBL:Y18817) transcriptional regulator of LysR family (307 aa), fasta scores opt: 274 z-score: 302.6 E(): 1.8e-09 31.3% identity in 336 aa overlap and (EMBL:AL136058) putati [...]
  
     0.737
SCO7538
SC8G12.14, possible LysR-family transcriptional regulator, len: 322 aa. Similar to many regulators e.g. Escherichia coli SW:OXYR_ECOLI(EMBL:J04553) hydrogen peroxide-inducible genes activator, OxyR (305 aa), fasta scores opt: 323 z-score: 373.2 E(): 2.5e-13 29.4% identity in 296 aa overlap and Streptomyces coelicolor TR:CAB71819(EMBL:AL138662) putative LysR-family transcriptional regulator, SC8E4A.14C (300 aa), fasta scores opt: 488 z-score: 563.0 E(): 6.7e-24 34.0% identity in 288 aa overlap. Contains a Prosite hit to PS00044 Bacterial regulatory proteins, lysR family signature and a [...]
  
     0.726
SCO7438
SC6D11.34, possible LysR-family transcriptional regulatory protein, len: 311 aa. Similar to many LysR-family regulators involved in the control of nodulation e.g. Rhizobium sp. (strain NGR234) SW:NOD1_RHISN(EMBL:AE000065) nodulation protein D I (322 aa), fasta scores opt: 449 z-score: 537.5 E(): 1.6e-22 32.3% identity in 294 aa overlap. Contains a Prosite hit to PS00044 Bacterial regulatory proteins, lysR family signature and Pfam matches to PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family and Pfam match to entry PF01046 NodD_C_term, NodD transcription activato [...]
  
     0.677
SCO0262
SCF1.04, probable LysR-family transcriptional regulator, len: 311 aa; similar to many transcriptional regulators especially in the N-terminal region, e.g. SW:OXYR_MYCAV regulator of hydrogen peroxide responsive genes from Mycobacterium avium (311 aa) fasta scores; opt: 292, z-score: 329.4, E(): 5.5e-11, (36.6% identity in 191 aa overlap). Contains Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family and Prosite match to PS00044 Bacterial regulatory proteins, lysR family signature.
  
     0.536
SCO7603
SC2H2.01c, probable lysR-family transcriptional regulator (fragment), len: >162 aa; similar to N-terminal domain of SW:TFDR_ALCEU (EMBL:M98445) Alcaligenes eutrophus transcriptional regulatory protein TdfR/TdfS, 295 aa; fasta scores: opt: 240 z-score: 294.4 E(): 7.3e-09; 37.2% identity in 145 aa overlap and of TR:CAB55524 (EMBL:AL117322) Streptomyces coelicolor putative LysR-family transcriptional regulator SCF1.04, 311 aa; fasta scores: opt: 461 z-score: 473.3 E(): 1.1e-20; 51.0% identity in 153 aa overlap. Contains Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-he [...]
  
     0.484
SCO5915
Conserved hypothetical protein; SC10A5.20, unknown, len: 171 aa; weak similarity to part of TR:P79078 (EMBL:Y10421) DELTA-9 FATTY ACID DESATURA SE (EC 1.14.99.5) from CRYPTOCOCCUS CURVATUS (555 aa), fast a scores; opt: 83 z-score: 221.8 E(): 3.7e-05, 25.1% identi ty in 171 aa overlap.
  
    0.467
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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