STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SCO5932Arabinofuranosidase; Involved in the degradation of xylan and is a key enzyme in the complete degradation of the plant cell wall. It has a specific arabinofuranose-debranching activity on xylan from gramineae. Acts synergistically with the xylanases and binds specifically to xylan. From small arabinoxylo-oligosides (ranging from arabinoxylotriose to arabinoxylohexaose), it liberates arabinose and, after prolonged incubation, the purified enzyme exhibits some xylanolytic activity as well (By similarity); Belongs to the glycosyl hydr olase 62 family. (475 aa)    
Predicted Functional Partners:
SCO0674
SCF91.34c, xysA, secreted endo-1,4-beta-xylanase (EC 3.2.1.8), len: 450 aa. Highly similar to many including: Streptomyces lividans SW:XYNA_STRLI(EMBL:M64551) endo-1,4-beta-xylanase A precursor (EC 3.2.1.8) (477 aa),fasta scores opt: 1313 z-score: 1280.4 E(): 0 49.0% identity in 459 aa overlap and Streptomyces halstedii TR:Q59922(EMBL:U41627) endo-1,4-beta-xylanase (EC 3.2.1.8) (461 aa), fasta scores opt: 2301 z-score: 2238.0 E():0 76.9% identity in 438 aa overlap. Contains Pfam matches to entries PF00553 CBD_2, Cellulose binding domain and Pfam match to entry PF00331 Glyco_hydro_10, G [...]
 
 0.951
SCO1883
Putative xylanase; SCI7.01c, partial CDS, possible xylanase, len: >95aa; similar to the N-terminal region of many eg. TR:O30426 (EMBL:AF005383) xylanase from the thermophile Caldocellum saccharolyticum (1347 aa) fasta scores; opt: 263, z-score: 357.5, E(): 1.4e-12, (35.2% identity in 91 aa overlap); SCI39.30c, probable xylanase (fragment), len: >458 aa; similar to TR:Q9WXE8 (EMBL:AB022865) Prevotella ruminicola xylosidase, 452 aa; fasta scores: opt: 553 Z-score: 572.6 bits: 115.2 E(): 2.6e-24; 37.954% identity in 303 aa overlap; Belongs to the glycosyl hydrolase 43 family.
   
 0.911
SCO7682
SC4C2.17, probable non-ribosomal peptide synthase, len: 2229 aa; similar to TR:AAG02364 (EMBL:AF210249) Streptomyces verticillus peptide synthetase NRPS2-1 BlmIV, 2626 aa; fasta scores: opt: 2485 z-score: 2429.3 E(): 0; 37.9% identity in 2203 aa overlap, to SW:HMP2_YEREN (EMBL:L18881) Yersinia enterocolitica high-molecular-weight protein 2 Irp2, 2035 aa; fasta scores: opt: 2251 z-score: 2201.3 E(): 0; 33.3% identity in 2022 aa overlap to TR:CAA18919 (EMBL:AL023496) Streptomyces coelicolor probable peptide synthase SC1A6.21, 1407 aa; fasta scores: opt: 1764 z-score: 1430.4 E(): 0; 40.0% [...]
  
  
 0.827
SCO0105
SCJ11.34c, xlnC, endo-1,4-beta-xylanase (putative secreted protein), len: 241 aa; highly similar to many endo-1,4-beta-xylanases e.g. SW:XYNC_STRLI from Streptomyces lividans (240 aa) fasta scores; opt: 1605, z-score: 1785.1, E(): 0, (97.9% identity in 241 aa overlap) and SW:XYNA_BACSU from Bacillus subtilis (213 aa) fasta scores; opt: 813, z-score: 910.7, E(): 0, (58.8% identity in 221 aa overlap). Contains Pfam match to entry PF00457 Glyco_hydro_11, Glycosyl hydrolases family 11 and Prosite matches to PS00777 Glycosyl hydrolases family 11 active site signature 2 and PS00776 Glycosyl [...]
 
     0.768
SCO2292
SCC75A.38, xlnB, secreted endo-1,4-beta-xylanase B (xylanase B), len: 335 aa. Almost identical to Streptomyces lividans SW:XYNB_STRLI(EMBL:M64552) endo-1,4-beta-xylanase B precursor (xylanase B) (EC 3.2.1.8) (334 aa), fasta scores opt: 2266 z-score: 2249.3 E():0 98.2% identity in 335 aa overlap. Also similar to Streptomyces coelicolor TR:CAB52919 (EMBL:AL109949) endo-1,4-beta-xylanase, XlnC (241 aa), fasta scores opt: 1087 z-score: 970.6 E():0 71.9% identity in 224 aa overlap and to the adjoining CDS on this cosmid, AxeA, (335 aa), fasta scores opt: 652 z-score: 585.8 E(): 2.9e-27 56.2 [...]
 
     0.767
SCO5786
SC4H2.07c, possible secreted hydrolase, len: 400 aa; similar in N-terminus to many e.g GUNA_STRLI P27035 endoglucanase CelA precursor (459 aa), fasta scores; opt: 376 z-score: 257.5 E(): 4e-07, 37.7% identity in 175 aa overlap. Contains a very Thr- Pro-rich region at aa 143-170, a possible N-terminal signal sequence and an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. C-terminal region has no apparent similarities. Also contains a TTA leucine codon; a potential target for action of bldA.
 
     0.766
SCO1187
SCG11A.18, celB, secreted cellulase B precursor, len: 381 aa; identical to TR:Q54331 (EMBL:U04629) Streptomyces lividans cellulase precursor, celB, 381 aa and similar to SW:GUX_CELFI (EMBL:M15824) Cellulomonas fimi exoglucanase/xylanase precursor [includes: exoglucanase (EC 3.2.1.91) (exocellobiohydrolase) (1,4-beta-cellobiohydrolase) (beta-1,4- glycanase Cex); endo-1,4-beta-xylanase B (EC 3.2.1.8) (xylanase B) Cex or XynB, 484 aa; fasta scores: opt: 422 z-score: 450.5 E(): 1e-17; 48.8% identity in 123 aa overlap. Contains two matches to Pfam entries PF01670 Glyco_hydro_12, Glycosyl hy [...]
 
     0.740
SCO4975
2SCK31.35, conserved hypothetical protein, len: 680 aa; similar to SW:YYAL_BACSU (EMBL:D26185) Bacillus subtilis hypothetical 78.8 kDa protein in TetB-ExoA intergenic region YyaL, 689 aa; fasta scores: opt: 1541 z-score: 1751.9 E(): 0; 39.2% identity in 683 aa overlap. Contains match to Prosite entry PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature.
    
   0.735
SCO1110
2SCG38.03, probable secreted lyase, len: 266 aa; similar to TR:Q04701 (EMBL:M94691) Fusarium solani pectate lyase A precursor (EC 4.2.2.2) PelA, 242 aa; fasta scores: opt: 605 z-score: 664.1 E(): 1.5e-29; 43.6% identity in 236 aa overlap. Contains possible N-terminal region signal peptide sequence.
  
     0.731
SCO3232
SCE63.01, partial CDS, cdaPS3, CDA peptide synthetase III, len: >332 aa; Constitutes the N-terminus of cdaPS3, CDA peptide synthetase III, part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This partial CDS encodes the N-terminus of a subunit of this enzyme suspected to be responsible for the addition of 2 amino acids to the peptide antibiotic. This ORF overlaps the upstream (cdaPSII) by one base indicating possible tra [...]
  
  
 0.725
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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