STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO5948SC7H1.18, possible oxidoreductase, len: 397 aa; weak similarity to TCMG_STRGA P39888 tetracenomycin polyketide synthesis hydroxylase (572 aa), fasta scores; opt: 72 z-score: 275.1 E(): 4e-08, 26.0% identity in 369 aa overlap. Also similar to M. tuberculosis hypothetical protein Y08M_MYCTU Q11058 MTCY50.22c (372 aa), fasta scores; opt: 949 z-score: 613.3 E(): 5.8e-27, 45.9% identity in 355 aa overlap. (397 aa)    
Predicted Functional Partners:
SCO5947
SC7H1.17, probable integral membrane protein, len: 465 aa; weakly similar to many eg. Mycobacterium tuberculosis TR:O07753 (EMBL:Z97193) MTCY180.41C (687 aa), fasta scores; opt: 440 z-score: 332.4 E(): 2.5e-11, 26.6% identity in 413 aa overlap. Contains possible hydrophobc membrane spanning regions.
 
    0.846
SCO5946
SC7H1.16, putative membrane protein, Gly-, Ala-rich protein, len: 257 aa. Contains possible hydrophobic membrane spanning regions.
 
     0.792
SCO5944
Hypothetical protein SC7H1.14; SC7H1.14, unknown, len: 382 aa.
 
     0.789
SCO5943
SC7H1.13, probable hydrolase, len: 261; weak similarity to several diverse hydrolases eg. TODF_PSEPU P23133 2-hydroxy-6-oxo-2,4-heptadienoate hydrolase (276 aa), fasta scores; opt: 196 z-score: 344.3 E(): 5.5e-12, 30.7% identity in 270 aa overlap.
  
    0.742
SCO5945
SC7H1.15, probable transferase, len: 606 aa; similar to TR:Q54353 (EMBL:X64651) S.lincolnensis lmbA gene for lincomycin condensing protein (601 aa), fasta scores; opt: 921 z-score: 1470.0 E(): 0, 45.8% identity in 600 aa overlap and to other gamma-glutamyl transferases.
  
    0.742
SCO5321
Polyketide hydroxylase; Involved in developmentally regulated synthesis of a compound biosynthetically related to polyketide antibiotics which is essential for spore color in Streptococcus coelicolor; Belongs to the PheA/TfdB FAD monooxygenase family.
  
     0.583
SCO5942
Hypothetical protein SC7H1.12; SC7H1.12, unknown, len: 205 aa; very weak similarity to downstream ORF SC7H1.21 (203 aa), (E(): 0.085, 26.9% identity in 208 aa overlap). Contains possible Helix-turn-helix motif at aa 41-62, Score 1089 (+2.90 SD).
 
     0.503
SCO0699
Hypothetical protein SCF42.09c; SCF42.09c, unknown, len: 97 aa.
  
    0.492
SCO3219
SCE8.12c, possible lipase (putative secreted protein), len: 391 aa; weak similarity to many eukaryotic lipases e.g. SW:PAFA_CAVPO platelet-activating factor-acetylhydrolase from guinea pig (Cavia porcellus) (436 aa) fasta scores; opt: 153, z-score: 161.7, E(): 0.11, (22.9% identity in 319 aa overlap). Contains PS00120 Lipases, serine active site. Contains possible N-terminal region signal peptide sequence.
  
    0.467
SCO5940
Transferase; SC7H1.10, probable transferase, len: 219 aa; similar to eg. MENG_ECOLI P32165 s-adenosylmethionine:2-demethylmenaquinone methyltransferase (161 aa), fasta scores; opt: 211 z-score: 265.9 E(): 1.3e-07, 34.1% identity in 126 aa overlap.
 
   
 0.440
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.