STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO5951SC7H1.21, probable transcriptional regulator, len: 203 aa; similar to many eg. Streptomyces hygroscopicus TR:Q54288 (EMBL:X86780) regulator of antibiotic transport complexes (204 aa), fasta scores; opt: 263 z-score: 351.4 E(): 2.2e-12, 33.7% identity in 196 aa overlap. Contains probable Helix-turn-helix motif at aa 41-61, Score 1399 (+3.95 SD) and Pfam match to entry tetR PF00440, Bacterial regulatory proteins, tetR family, score 23.60. (203 aa)    
Predicted Functional Partners:
SCO5950
SC7H1.20c. probable export protein, len: 483; similar to many members of the drug resistance translocase family eg. Streptomyces lipmanii PUR8_STRLP P42670 puromycin resistance protein pur8 (503 aa), fasta scores; opt: 907 z-score: 636.6 E(): 2.9e-28, 38.6% identity in 477 aa overlap. Also weakly similar to upstream protein SC7H1.27 (533 aa) (E(): 7.9e-15, 28.6% identity in 461 aa overlap).
       0.607
SCO0322
SCF12.01c, possible ABC transport ATP-binding subunit, len: >230aa; similar to many eg. SW:TLRC_STRFR tylosin resistance ATP-binding protein from Streptomyces fradiae (548 aa) fasta scores; opt: 1017, z-score: 1131.8, E(): 0, (69.0% identity in 232 aa overlap). Contains Prosite match to PS00211 ABC transporters family signature and Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop); SC5G9.31c, probable ABC-transporter ATP-binding protein, partial CDS, len: >371 aa; similar ATP-binding components from antibiotic resistance export systems e.g. SW:TLRC_STRFR (EMBL:M57437), tlr [...]
       0.560
SCO5808
Conserved hypothetical protein SC4H2.29; SC4H2.29, unknown, len: 219 aa; highly similar to several eukaryotic hypothetical proteins e.g. Arabidopsis thaliana TR:O04035 (EMBL:AC000106) F7G19.18 (281 aa), fasta scores; opt: 482 z-score: 1008.5 E(): 0, 47.0% identity in 217 aa overlap. Contains PS00175 Phosphoglycerate mutase family phosphohistidine signature and Pfam match to entry PGAM PF00300, Phosphoglycerate mutase family, score 20.30.
       0.560
SCO5809
SC4H2.30, possible hydrolase, len: 301 aa; some similarity to several e.g. DRAG_RHORU P14300 adp-ribosylglycohydrolase (294 aa), fasta scores; opt: 92 z-score: 265.8 E(): 1.4e-07, 25.3% identity in 296 aa overlap.
       0.560
SCO3644
SCH10.22c, possible lipase/esterase, len: 301 aa; weakly similar to many esterases e.g. SW:EST1_CAEEL (EMBL:M96145) Caenorhabditis elegans gut esterase precursor (562 aa), fasta scores; opt: 150 z-score: 166.4 E(): 0.059, 29.3% identity in 280 aa overlap. Contains PS00120 Lipases, serine active site.
       0.527
SCO5811
SC5B8.01, probable transcriptional regulator, partial CDS, overlaps and extends SC4H2.32, len: > 140 aa; SC4H2.32, probable transcriptional regulator, partial CDS, len: >111 aa; similar to many e.g. TR:D1022772 (EMBL:D85417) HemR from Propionibacterium freudenreichii (243 aa), fasta scores; opt: 262 z-score: 366.7 E(): 3.3e-13, 46.5% identity in 101 aa overlap. Contains Pfam match to entry tetR PF00440, Bacterial regulatory proteins, tetR family, score 29.06.
  
     0.490
SCO3167
SCE87.18c, possible tetR-family transcriptional regulator, len: 199 aa. Similar to many including: Propionibacterium freudenreichii TR:P72185(EMBL:U51164) repressor protein (HemR protein) (259 aa), fasta scores opt: 222 z-score: 276.8 E(): 4.8e-08 30.6% identity in 196 aa overlap and Streptomyces coelicolor TR:CAB45568(EMBL:AL079355) putative transcriptional regulator (fragment) SC4C6.04 (204 aa), fasta scores opt: 539 z-score: 660.1 E(): 2.2e-29 42.9% identity in 191 aa overlap. Contains a Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family.
  
     0.430
SCO5952
SC7H1.22, putative membrane protein, len: 250 aa. Contains possible hydrophobic membrane spanning regions.
       0.424
SCO5953
SC7H1.23, putative membrane protein, len: 913 aa; weakly similar to many members of the eukaryotic beta-transducin family e.g. YA3A_SCHPO Q09715 hypothetical Trp-Asp repeats containing protein (614 aa), fasta scores; opt: 139 z-score: 352.6 E(): 1.9e-12, 28.8% identity in 250 aa overlap. Contains possible membrane spanning domain around aa 200 and 3x Pfam match to entry G-beta PF00400, WD domain, G-beta repeats, scores; 27.34, 28.55 and 25.74.
       0.424
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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