STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO6053SC1B5.13c, putative membrane protein, len: 262 aa; highly similar to many members of the band 7/mec2 family of membrane proteins e.g. BAN7_MOUSE P54116 mus musculus (mouse). erythrocyte band7 protein (stomatin) (284 aa), fasta scores; opt: 709 z-score: 1075.9 E(): 0, 47.1% identity in 223 aa overlap. Contains possible hydrophobic membrane spanning region. (262 aa)    
Predicted Functional Partners:
SCO3404
Cell division protein ftsH homolog; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
   
 0.860
SCO5587
Cell division protein FtsH homolog; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
   
 0.860
SCO6055
Probable carbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family.
   
   0.787
SCO6054
Putative transmembrane transport protein; SC9B1.01c, partial CDS, possible integral membrane protein, len: >149aa; similar to many eg. TR:CAB38499 (EMBL:AL035636) putative integral membrane protein from Streptomyces coelicolor (830 aa) fasta scores; opt: 385, z-score: 428.6, E(): 1.5e-16, (44.7% identity in 141 aa overlap). Contains several possible membrane spanning hydrophobic regions; SC1B5.14c, probable transmembrane transport protein, partial CDS, len: >381 aa; similar to hypothetical membrane proteins from many organisms e.g. Mycobacterium tuberculosis TR:P96878 (EMBL:Z92771) MTC [...]
  
    0.781
SCO6056
SC9B1.03c, possible secreted protein, len: 133aa; contains possible N-terminal signal sequence.
       0.722
SCO6050
SC1B5.10c, probable lipoprotein, len: 289 aa; contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
       0.692
SCO1648
AAA ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
   
 
 0.663
SCO6051
SC1B5.11c, probable iron-sulfur binding oxidoreductase, len: 513 aa; similar to e.g. ORDL_ECOLI P37906 escherichia coli. probable oxidoreductase (426 aa), fasta scores; opt: 303 z-score: 334.4 E(): 2.1e-11, 25.4% identity in 389 aa overlap. Contains PS00199 and PS00200 Rieske iron-sulfur protein signatures 1 and 2, and Pfam match to entry Rieske PF00355, Rieske iron-sulfur protein, score 49.39.
  
 
 0.635
SCO6052
SC1B5.12c, putative membrane protein, len: 495 aa; similar to TR:Q9X9W6 (EMBL:AL096743) Streptomyces coelicolor hypothetical protein SCI7.24c, 490 aa; fasta scores: opt: 1059 Z-score: 1198.3 E(): 4.1e-59; 48.081% identity in 495 aa overlap. Contains possible hydrophobic membrane spanning region.
       0.621
SCO2948
SCE59.07c, hypothetical protein, len: 193 aa; similar to various hypothetical proteins, e.g. TR:P71608 (EMBL:Z80233) Mycobacterium tuberculosis hypothetical 21.8 kD protein CY10H4.38, 202 aa; fasta scores: opt: 525 z-score: 594.5 E(): 1.1e-25; 46.7% identity in 182 aa overlap; Belongs to the UPF0301 (AlgH) family.
   
    0.614
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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