STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO6066SC9B1.13c, cvnD6, possible ATP/GTP-binding protein, len: 181aa; similar to others egs. TR:O50391 (EMBL:AL009198) hypothetical protein from Mycobacterium tuberculosis (193 aa) fasta scores; opt: 689, z-score: 849.1, E(): 0, (61.4% identity in 166 aa overlap) and two putative ATP/GTP-binding proteins from Streptomyces coelicolor: TR:O86519 (EMBL:AL031124) (174 aa) fasta scores; opt: 665, z-score: 820.6, E(): 0, (55.0% identity in 171 aa overlap) and TR:CAA19989 (EMBL:AL031124) (174 aa) fasta scores; opt: 662, z-score: 817.0, E(): 0, (55.6% identity in 171 aa overlap). Contains Prosite ma [...] (181 aa)    
Predicted Functional Partners:
SCO6068
Conserved hypothetical protein; SC9B1.15c, cvnB6, unknown, len: 119 aa; similar to other hypothetical proteins egs. two from Streptomyces coelicolor: TR:O86521 (EMBL:AL031124) (140 aa) fasta scores; opt: 331, z-score: 424.2, E(): 2.6e-16, (41.5% identity in 130 aa overlap) and TR:O86524 (EMBL:AL031124) (137 aa) fasta scores; opt: 325, z-score: 416.9, E(): 6.7e-16, (44.3% identity in 122 aa overlap), and TR:O50393 (EMBL:AL009198) from Mycobacterium tuberculosis (130 aa) fasta scores; opt: 282, z-score: 364.1, E(): 5.8e-13, (39.1% identity in 115 aa overlap).
 
 
 0.973
SCO6067
Hypothetical protein; SC9B1.14c, cvnC6, unknown, len: 119 aa; similar to other hypothetical proteins egs. two from Streptomyces coelicolor: TR:O86520 (EMBL:AL031124) (190 aa) fasta scores; opt: 242, z-score: 321.0, E(): 1.5e-10, (39.8% identity in 118 aa overlap) and TR:O86523 (EMBL:AL031124) (132 aa) fasta scores; opt: 228, z-score: 305.7, E(): 1e-09, (39.3% identity in 112 aa overlap), and TR:O50392 (EMBL:AL009198) from Mycobacterium tuberculosis (122 aa) fasta scores; opt: 188, z-score: 255.2, E(): 6.8e-07, (37.5% identity in 120 aa overlap).
 
    0.950
SCO6069
SC9B1.16c, cvnA6, possible large secreted protein, len: 877aa; similar to two neighbouring hypothetical proteins from Streptomyces coelicolor TR:O86525 (EMBL:AL031124) (1329 aa) fasta scores; opt: 1056, z-score: 919.5, E(): 0, (30.4% identity in 891 aa overlap) TR:O86522 (EMBL:AL031124) (1111 aa) fasta scores; opt: 804, z-score: 701.8, E(): 9e-32, (28.4% identity in 849 aa overlap). Contains possible N-terminal signal sequence.
 
    0.891
SCO1160
SCG8A.14c, cvnA3, possible membrane protein, len: 862 aa; similar to many from Streptomyces coelicolor e.g. TR:Q9X836 (EMBL:AL049727) putative large secreted protein (877 aa) fasta scores; opt: 1248, z-score: 1146.3, E(): 0, 34.7% identity in 836 aa overlap. Contains possible membrane-spanning hydrophobic regions.
 
     0.875
SCO1159
SCG8A.13c, cvnB3, hypothetical protein, len: 145 aa; strongly similar to many from Streptomyces coelicolor e.g. TR:Q9X835 (EMBL:AL049727) hypothetical 14.4 kD protein (139 aa) fasta scores; opt: 412, z-score: 512.5, E(): 4.2e-21, 52.8% identity in 127 aa overlap. Also strongly similar to neighbouring CDS SCG8A.09c. Contains Pfam match to entry PF01860 DUF42, Protein of unknown function.
 
 
 0.870
SCO1401
Conserved hypothetical protein; SC1A8A.21c, cvnB4, unknown, len: 144 aa; similar to others from Streptomyces coelicolor and Mycobacterium tuberculosis e.g. TR:Q9X835 (EMBL:AL049727) hypothetical protein from Streptomyces coelicolor (139 aa) fasta scores; opt: 408, z-score: 500.5, E(): 1.9e-20, 47.6% identity in 143 aa overlap. Local genetic arrangement also seems to be conserved for the Streptomyces coelicolor paralogues.
 
 
 0.869
SCO5539
SC1C2.20c, cvnB2, unknown, len: 140 aa; similar to M. tuberculosis hypothetical protein TR:O50393 (EMBL:AL009198) MTV004.21c (130 aa), fasta scores; opt: 445 z-score: 754.7 E(): 0, 56.9% identity in 116 aa overlap. 94.2% identical to upstream gene SC1C2.24c.
 
 
 0.869
SCO5543
SC1C2.24c, cvnB1, unknown, len: 137 aa; M. tuberculosis hypothetical protein TR:O50393 (EMBL:AL009198) MTV004.21c (130 aa), fasta scores; opt: 466 z-score: 804.8 E(): 0, 58.6% identity in 116 aa overlap. 94.2% identical to downstream gene SC1C2.20c.
 
 
 0.868
SCO1155
SCG8A.09c, conserved hypothetical protein, len: 137aa; strongly similar to many from Streptomyces coelicolor eg. TR:Q9X835 (EMBL:AL049727) hypothetical 14.4 kD protein (139 aa) fasta scores; opt: 366, z-score: 458.5, E(): 4.3e-18, 48.0% identity in 127 aa overlap. Also strongly similar to neighbouring CDS SCG8A.13c. Contains Pfam match to entry PF01860 DUF42, Protein of unknown function.
 
 
 0.867
SCO1629
Conserved hypothetical protein SCI41.12c; SCI41.12c, cvnB9, unknown, len: 135 aa. Similar to TR:CAB41561 (EMBL:AL049727) Streptomyces coelicolor SC9B1.15C hypothetical 14.3 kD protein, 137 aa; fasta scores: opt: 266 z-score: 339.1 E(): 1.6e-11; 37.0% identity in 127 aa overlap and to TR:Q9AJP3 (EMBL:AB044803) Streptomyces girseus ORF2, 135 aa; fasta scores: opt: 559 Z-score: 671.5 E(): 9e-30; 62.687% identity in 134 aa overlap.
 
 
 0.865
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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