STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO6071SC9B1.18, cprB, A-factor receptor homolog, len: 215 aa; previously sequenced therefore identical to TR:O66122 (EMBL:AB000385) CprB, A-factor receptor homolog from Streptomyces coelicolor. Also similar to many others from Actinomycetes e.g. TR:Q54189 (EMBL:D49782) A-factor receptor from Streptomyces griseus (276 aa) fasta scores; opt: 315, z-score: 392.1, E(): 1.6e-14, (36.5% identity in 219 aa overlap). Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family. (215 aa)    
Predicted Functional Partners:
SCO0520
SCF6.16, putative tetR family transcriptional regulator, len: 194 aa. Weakly similar to many other tetR family regulators e.g. Streptomyces sp. TR:O24741 (EMBL:AB001683) FarA (221 aa), fasta scores opt: 161 z-score: 205.5 E(): 0.00044 28.4% identity in 190 aa overlap and Streptomyces coelicolor TR:O86852 (EMBL:AJ007731) gamma-butyrolactone binding protein (215 aa), fasta scores opt: 149 z-score: 191.2 E(): 0.0028 26.6% identity in 188 aa overlap. Also highly similar to Streptomyces coelicolor SCF51A.08 (EMBL; AL121596) putative tetR family transcriptional regulator (227 aa), fasta scor [...]
  
   
 0.801
SCO6266
SCAH10.31, scbA, len: 314 aa; identical to previously sequenced TR:O86851 (EMBL:AJ007731) Streptomyces coelicolor ScbA protein, 314 aa and to SW:AFSA_STRGR (EMBL:M24250) Streptomyces griseus possible A-factor biosynthesis enzyme AfsA, 301 aa; fasta scores: opt: 1345 z-score: 1570.4 E(): 0; 66.1% identity in 292 aa overlap.
 
   
 0.732
SCO6072
Conserved hypothetical protein; SC9B1.19, unknown, len: 666aa; similar to many hypothetical proteins from eukaryotes eg. TR:O45417 (EMBL:Z92832) from Caenorhabditis elegans (450 aa) fasta scores; opt: 395, z-score: 410.1, E(): 1.6e-15, (28.0% identity in 447 aa overlap).
       0.634
SCO3201
SCE22.18c, probable tetR-family transcriptional regulator, len: 236 aa; similar to TR:CAB62751 (EMBL:AL133424) Streptomyces coelicolor putative tetR-family transcriptional regulator SCF56.06, 213 aa; fasta scores: opt: 311 z-score: 346.2 E(): 8e-12; 38.1% identity in 194 aa overlap and to SW:TCMR_STRGA (EMBL:M80674) Streptomyces glaucescens tetracenomycin C transcriptional repressor TcmR, 226 aa; fasta scores: opt: 254 z-score: 284.8 E(): 2.1e-08; 32.2% identity in 214 aa overlap. Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family and possible helix-t [...]
  
   
 0.588
SCO6265
SCAH10.30c, scbR, gamma-butyrolactone binding protein, len: 215 aa; identical to previously sequenced TR:O86852 (EMBL:AJ007731) Streptomyces coelicolor gamma-butyrolactone binding protein, 215 aa and to TR:O24741 (EMBL:AB001683) Streptomyces sp. FarA, 221 aa; fasta scores: opt: 771 z-score: 937.4 E(): 0; 57.2% identity in 208 aa overlap. Contains match to Pfam entry PF00440 tetR, Bacterial regulatory proteins, tetR family and to Prosite entry PS01081 Bacterial regulatory proteins, tetR family signature. Contains also a possible helix-turn-helix motif at residues 30..51 (+3.66 SD).
 
   
0.566
SCO2792
SCC105.23, adpA, araC-family transcriptional regulator, len: 398 aa; highly similar to TR:BAA86265 (EMBL:AB023785) Streptomyces griseus AdpA, 405 aa; fasta scores: opt: 2219 z-score: 2270.5 E(): 0; 84.4% identity in 410 aa overlap and to TR:Q9XA73 (EMBL:AL096822) Streptomyces coelicolor putative araC-family transcriptional regulator SCGD3.05, 334 aa; fasta scores: opt: 878 z-score: 904.2 E(): 0; 45.7% identity in 313 aa overlap. Contains Pfam match to entry PF00165 HTH_AraC, Bacterial regulatory helix-turn-helix proteins, araC family and match to Prosite entry PS00041 Bacterial regulat [...]
      
 0.516
SCO0521
SCF11.01, possible tetR family transcriptional regulator, partial CDS, len: >32 aa. Previously annotated as Streptomyces coelicolor SCF6.17, possible tetR family trasncriptional regulator, len: >193 aa. Similar to several e.g. Streptomyces coelicolor TR:CAB56142 (EMBL; AL117669) putative transcriptional regulator SCF12.15 (188 aa), fasta scores opt:446 z-score: 521.2 E(): 1.2e-21 43.5% identity in 184 aa overlap and Streptomyces glaucescens SW:TCMR_STRGA (EMBL; M80674) tetracenomycin C transcriptional repressor (226 aa), fasta scores opt: 202 z-score: 242.5 E(): 3.8e-06 29.3% identity [...]
      
 0.483
SCO0522
SCF11.02, probable oxidoreductase, len: 262 aa; similar to TR:O54197 (EMBL:AJ000671) Streptomyces clavuligerus clavulanate-9-aldehyde reductase, 247 aa; fasta scores: opt: 501 z-score: 567.7 E(): 3e-24; 39.1% identity in 238 aa overlap. Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase and prosite match to entry PS00061 Short-chain dehydrogenases/reductases family signature. also similar to Streptomyces coelicolor SCF6.15c, 245 aa; fasta scores: opt: 818 z-score: 805.2 E():0; 56.5% identity in 237 aa overlap; Belongs to the short-chain dehydrogenases/reductases [...]
      
 0.483
SCO6073
Putative cyclase; Tow-domain protein where the N-terminal domain catalyzes the cyclization of farnesyl diphosphate (FPP) to a 85:15 mixture of the sesquiterpene alcohol germacradienol and the sesquiterpene hydrocarbon germacrene D. The C-terminal domain partially converts the germacradienol formed into geosmin, the characteristic odoriferous ('earthy aroma') constituent of Streptomyces species.
       0.472
SCO5158
Hypothetical protein SCP8.21; SCP8.21, unknown, len: 198 aa.
      
 0.422
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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