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hldE protein (Streptomyces coelicolor) - STRING interaction network
"hldE" - Bifunctional protein HldE in Streptomyces coelicolor
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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hldEBifunctional protein HldE; Catalyzes the phosphorylation of D-glycero-D-manno- heptose 7-phosphate at the C-1 position to selectively form D- glycero-beta-D-manno-heptose-1,7-bisphosphate; In the C-terminal section; belongs to the cytidylyltransferase family (463 aa)    
Predicted Functional Partners:
gmhA
Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate; Belongs to the SIS family. GmhA subfamily (231 aa)
   
  0.999
SCO6183
SC2G5.04, possible transferase, len- 335aa; similar to many eg. TR-O05195 (EMBL-U70982) heptosyl transferase I from Pseudomonas aeruginosa (355 aa) a protein known to be involved in the synthesis of lipopolysaccharide, fasta scores; opt- 240, z-score- 250.8, E()- 1.1e-06, (29.3% identity in 324aa overlap). Contains Pfam match to entry PF01075 Heptosyltranf, Heptosyl transferase, score 35.10,E-value7.1e-09 (335 aa)
   
  0.997
SCO6188
SC2G5.09, possible transferase, len- 566aa; C-terminal region similar to SW-RFAC_SALTY lipopolysaccharide heptosyltransferase-1 (317aa) blast scores; Sum P(2)= 1.3e-09, Identities= 46 /150 (30%), Positives = 70 /150 (46%) (566 aa)
 
   
  0.990
SCO6182
SC2G5.03, possible dehydratase, len- 285aa; N-terminal region similar to SW-HIS7_SALTY, HisB, imidazoleglycerol-phosphate dehydratase (354 aa) from Salmonella typhimurium fasta scores; opt- 207, z-score-191.1, E()- 0.0023, (29.4 %identity in 143 aa overlap). Also similar TR-Q54364 (EMBL-X79146) located within thelincomycin-production gene cluster of Streptomyces lincolnensis 78-11 (190 aa) fasta scores opt- 345, z-score-312.0, E()- 4.3e-10, (40.5% identity in 185 aa overlap) (285 aa)
 
   
  0.989
SCO6184
SC2G5.05, possible transferase, len- 312aa, C-terminal region similar to C-terminal from many eg. TR-Q47594 (EMBL-D43637) mannosyl transferase B from Escherichia coli fasta scores; opt- 149, z-score- 178.9, E()- 0.011, (32.0% identity in 150 aa overlap) (316 aa)
 
 
  0.977
SCO6180
Putative transferase; SC2G5.01, partial CDS, possible transferase, len->187aa; constitutes the C-terminal end of SC6C5.16 (EMBL-AL034 492) from Streptomyces coelicolor. Similar to the C-terminal region of many egs. SW-CMCH_NOCLA3’-hydroxymethylcephem- O-carbamoyltransferase, a protein involved in cephamycin synthesis in Nocardia lactamdurans(520 aa) fasta scores; opt - 373, z-score- 451.4, E()-7.4e-18, (40.1% identity in 167 aa overlap); SC6C5.16, partial CDS, unknown, len- 392aa; similar to many eg. SW-NOLO_RHISN nodulation associated protein NolNO from Rhizobium sp. (strain NGR234) ( [...] (546 aa)
 
        0.974
SCO6181
SC2G5.02, possible transferase, len- 344aa; similar to many eg. SW-EXOO_RHIME succinoglycan biosynthesis protein, ExoO, from Rhizobium meliloti (334 aa) fasta scores; opt-177, z-score- 202.6, E()- 0.00053, (29.5% identity in 278aa overlap). Contains Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferases, score 32.70,E-value 8.3e-06 (344 aa)
 
   
  0.973
SCO6185
SC2G5.06, possible transferase, len- 402aa; similar to many egs. SW-YV12_MYCTU hypothetical protein from Mycobacterium tuberculosis (480 aa) fasta scores; opt- 652, z-score- 737.4, E()- 0, (34.6% identity in 408 aa overlap) and TR-O84909 (EMBL-AF010182) glycosyl transferase, WbpY from Pseudomonas aeruginosa (371 aa) fasta scores; opt- 298, z-score- 340.5, E()- 1.1e-11, (29.4% identity in 326 aa overlap). Contains Pfam match to entry PF00534 Glycos_transf_1, Glycosyl transferases group 1, score 111.00, E-value 1.2e-30 (406 aa)
 
 
  0.967
SCO6190
SC2G5.11, possible transferase, len- 298aa; similar to many eg. TR-P74820 (EMBL-U51197) glycosyl transferase from Sphingomonas S88 (288 aa) fasta scores; opt- 167, z-score- 204.0, E()- 0.00045, (27.5% identity in 262 aa overlap). Contains Pfam match to entry PF00535 Glycos_transf_2,Glycosyl transferases, score 51.10, E-value 2.4e-11. NB this CDS is an imperfect duplicate of the neighbouring upstream CDS SC2G5.10 fasta scores; opt- 772, z-score- 804.0, E()- 0, (47.5% identity in 280 aa overlap) (298 aa)
 
   
  0.967
SCO6189
SC2G5.10, possible transferase, len- 317aa; similar to many eg. SW-EXOU_RHIME succinoglycan biosynthesis protein, ExoU from Rhizobium meliloti (342 aa) fasta scores; opt-203, z-score- 234.7, E()- 8.7e-06, (30.3% identity in 274aa overlap). Pfam match to entry PF00535 Glycos_transf_2,Glycosyl transferases, score 37.70, E-value 2.6e-07. NB this CDS is an imperfect duplicate of the neighbouring downstream CDS SC2G5.11 fasta scores; opt- 772, z-score- 700.7, E()-3.3e-34, (47.5% identity in 280 aa overlap) (317 aa)
 
   
  0.966
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor, Streptomyces coelicolor A3(2)
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