STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
SCO6247Putative allantoinase; Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring; Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family. (445 aa)    
Predicted Functional Partners:
SCO1487
SC9C5.11c, pyrB, aspartate carbamoyltransferase, len: 326 aa; similar to SW:PYRB_PSEPU (EMBL:M97253) Pseudomonas putida aspartate carbamoyltransferase (EC 2.1.3.2) PyrB, 334 aa; fasta scores: opt: 902 z-score: 1064.2 E(): 0; 47.3% identity in 311 aa overlap. Contains 2x Pfam matches to entry PF00185 OTCace, Aspartate/ornithine carbamoyltransferase and match to Prosite entry PS00097 Aspartate and ornithine carbamoyltransferases signature; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
 
 0.998
SCO6248
SCAH10.13, possible allantoicase, len: 376 aa; similar to SW:ALC_NEUCR (EMBL:J02927) Neurospora crassa allantoicase (EC 3.5.3.4) Alc, 354 aa; fasta scores: opt: 270 z-score: 320.1 E(): 1.9e-10; 35.0% identity in 334 aa overlap; Belongs to the allantoicase family.
 
 
 0.998
SCO1484
SC9C5.08c, pyrAA, carbamoyl-phosphate synthase, pyrimidine-specific, small chain, len: 380 aa; similar to SW:CARA_BACCL (EMBL:X73308) Bacillus caldolyticus carbamoyl-phosphate synthase, pyrimidine-specific, small chain (EC 6.3.5.5) PyrAA, 364 aa; fasta scores: opt: 826 z-score: 913.3 E(): 0; 45.3% identity in 362 aa overlap. Contains Pfam matches to entries PF00988 CPSase_sm_chain, Carbamoyl-phosphate synthase small chain, CPSase domain and PF00117 GATase, Glutamine amidotransferase class-I and match to Prosite entry PS00442 Glutamine amidotransferases class-I active site; Belongs to t [...]
  
 0.982
SCO1483
SC9C5.07c, pyrA, carbamoylphosphate synthetase large chain, len: 1102 aa; similar to SW:CARB_ECOLI (EMBL:V01500) Escherichia coli carbamoyl-phosphate synthase large chain (EC 6.3.5.5) CarB or PyrA, 1072 aa; fasta scores: opt: 3383 z-score: 3699.6 E(): 0; 55.0% identity in 1102 aa overlap. Contains 3x Pfam matches to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase (CPSase) and matches to Prosite entries 2x PS00866 Carbamoyl-phosphate synthase subdomain signature 1 and 2x PS00867 Carbamoyl-phosphate synthase subdomain signature.
 
 
 0.981
SCO6209
Hypothetical protein SC2G5.30; SC2G5.30, unknown, len: 191 aa; limited similarity to TR:O32141 (EMBL:Z99120) hypothetical protein from Bacillus subtilis (494 aa) fasta scores; opt: 204, z-score: 241.2,E(): 3.8e-06, (27.8% identity in 162 aa overlap).
 
  
 0.979
SCO4859
Hypothetical protein; SC5G8.27c, unknown, len: 183 aa; similar to TR:Q9Z593 (EMBL:AL035478) hypothetical protein from Streptomyces coelicolor (191 aa) fasta scores; opt: 164, z-score: 195.7, E(): 0.0019, 32.6% identity in 187 aa overlap.
 
  
 0.974
SCO7499
SCBAC17A6.32c, possible racemase, len: 241aa; similar to SW:Q00924 (HYUE_PSESN) hydantoin racemase from the native plasmid of Pseudomonas sp. strain NS671 (249 aa) fasta scores: opt: 564, Z-score: 617.1, 39.574% identity (39.744% ungapped) in 235 aa overlap.
 
  
 0.962
SCO1488
Pyrimidine operon regulatory protein; Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.
  
 
 0.849
SCO6211
Putative uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
 
  
 0.848
SCO6210
Hypothetical protein SC2G5.31; SC2G5.31, unknown, len: 133 aa; probably member of a family of transthyretin-like proteins, similar to many eg. SW:YEDX_ECOLI hypothetical transthyretin-like protein fromEscherichia coli (137 aa) fasta scores; opt: 149, z-score:198.9, E(): 0.00086, (40.9% identity in 127 aa overlap); Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
 
   
 0.832
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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