STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO6390SC3C8.09, probable integral membrane protein, len: 367 aa; similar to a hypothetical protein from M. tuberculosis Y07S_MYCTU MTCY02B10.28c (653 aa), fatsta scores; opt: 144 z-score: 314.2 E(): 2.9e-10, 30.6% identity in 281 aa overlap. Also similar to S. coelicolor SC7H1.03c (E(): 3e-18, 35.2% identity in 355 aa overlap). (367 aa)    
Predicted Functional Partners:
SCO3796
SCAC2.04, hypothetical protein, len: 722 aa; similar to TR:Q9RIW0 (EMBL:AL133278) Streptomyces coelicolor hypothetical 64.1 kDa protein (fragment) SCM11.01c, 588 aa; fasta scores: opt: 1053 z-score: 1177.1 E(): 0; 35.8% identity in 598 aa overlap.
 
   0.821
SCO2560
Conserved hypothetical protein; SCC77.27c, unknown, len: 792 aa. Weakly similar to Streptomyces coelicolor TR:O86807 (EMBL:AL031031) putative regulatory protein SC7C7.02C (916 aa), fasta scores opt: 447 z-score: 376.3 E(): 1.4e-13 34.1% identity in 954 aa overlap. The N-terminus is also similar Streptomyces coelicolor TR:Q53897(EMBL:X60316) OrfA within the AbaA pleiotropic regulatory locus for antibiotic production (192 aa), fasta scores opt: 248 z-score: 220.6 E(): 6.7e-05 37.1% identity in 178 aa overlap.
  
   0.820
SCO0451
SCF51A.29c, unknown, len: 284 aa. Similar to the C-terminus of many hypothetical proteins e.g. Mycobacterium tuberculosis SW:Y07S_MYCTU (EMBL; Z75555) hypothetical 69.5 KD protein CY02B10.28C (653 aa), fasta scores opt: 390 z-score: 451.1 E(): 9.1e-18 33.5% identity in 263 aa overlap. In addition to Bacillus subtilis SW:RSBU_BACSU (EMBL; L35574) sigma factor SibG regulation protein RsbU (335 aa), fasta scores opt: 206 z-score: 243.6 E(): 3.3e-06 24.3% identity in 185 aa overlap.
  
     0.761
SCO0946
Putative regulatory protein; SCM11.01c, hypothetical protein, len: >587 aa; similar to various hypothetical proteins, e.g. TR:Q9ZBJ0 (EMBL:AL035161) Streptomyces coelicolor conserved hypothetical protein SC9C7.20, 860 aa; fasta scores: opt: 588 z-score: 654.5 E(): 4.4e-29; 30.4% identity in 542 aa overlap; SCM10.35c, possible regulatory protein, (partial CDS), len: >141 aa; similar to TR:Q9ZBT2 (EMBL:AL034446)Streptomyces coelicolor putative regulatory protein SC1A9.20, 135 aa; fasta scores: opt: 286 z-score: 366.0 E(): 5.3e-13; 42.4% identity in 132 aa overlap.
  
     0.759
SCO3971
SCBAC25E3.08c, conserved hypothetical protein, len: 477 aa: similar to many from Streptomyces coelicolor e.g. TR:Q9RJ90 (EMBL:AL132973) hypothetical protein SCF91.35 (884 aa) fasta scores; opt: 458, Z-score: 470.1, 31.210% identity (34.507% ungapped) in 471 aa overlap.
  
     0.752
SCO3549
Putative anti-sigma factor antagonist; Positive regulator of sigma-B activity. Non-phosphorylated RsbV binds to RsbW, preventing its association with sigma-B. When phosphorylated, releases RsbW, which is then free to complex with and inactivate sigma-B (By similarity).
  
   0.729
SCO7573
SC5F1.27c, probable anti-sigma factor antagonist, len: 114 aa; similar to SW:RSBV_STRCO (EMBL:AF134889) Streptomyces coelicolor anti-sigma factor B antagonist BldG, 113 aa; fasta scores: opt: 320 z-score: 436.5 E(): 8.8e-17; 49.5% identity in 99 aa overlap. Contains Pfam match to entry PF01740 STAS, STAS domain; Belongs to the anti-sigma-factor antagonist family.
  
   0.694
SCO3723
SCH22A.01, possible regulatory protein (fragment), len: >465 aa; similar to TR:CAB59599 (EMBL:AL132662) Streptomyces coelicolor hypothetical regulatory protein SCF11.22, 877 aa; fasta scores: opt: 708 z-score: 765.1 E(): 0; 34.5% identity in 466 aa overlap. Contains Pfam match to entry PF01590 GAF, GAF domain and possible coiled-coil region at residues 48..60; SCH35.01c, partial CDS, unknown, len: >76aa.
  
     0.657
SCO7748
SC8D11.39, hypothetical protein, len: 567 aa; similar to TR:CAC14487 (EMBL:AL446003) Streptomyces coelicolor putative DNA-binding protein SC5E9.07, 531 aa; fasta scores: opt: 473 z-score: 523.3 E(): 1.3e-21; 30.3% identity in 433 aa overlap. Contains match to Prosite entry PS00237 G-protein coupled receptors signature and 4x degenerate repeat: HAVVP.
  
     0.654
SCO6156
SC1A9.20, possible regulatory protein, len: 135aa; similar to TR:O69204 (EMBL:U33059) hypothetical protein from Amycolatopsis mediterranei S699 (144 aa) fasta scores; opt:225, z-score:335.1. E(): 2.2e-11, (41.7% identity in 115 aa overlap). Also similar to TR:Q53897 (EMBL:X60316) AbaA regulatory locus for antibiotic production in Streptomyces coelicolor (192 aa), fasta scores; opt: 155, z-score: 284.6, E(): 1.4e-08, (33.3% identity in 120 aa overlap).
  
   0.632
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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