STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SCO6415Putative D-hydantoinase; Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin derivatives; Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. (467 aa)    
Predicted Functional Partners:
SCO6414
Hypothetical protein; SC1A6.03, possible hydrolase, len: 280; similar to e.g. BUP_RAT Q03248 rattus norvegicus (rat). beta-ureidopropionase (393 aa), fasta scores; opt: 530 z-score: 759.6 E(): 0, 36.6% identity in 279 aa overlap.
 
 0.997
SCO6411
SC3C8.30, probable hydrolase, len: 280 aa; similar to e.g. BUP_RAT beta-ureidopropionase (EC 3.5.1.6) (beta-alanine synthase) (393 aa), fasta scores; opt: 529 z-score: 700.2 E(): 9.2e-32, 37.2% identity in 296 aa overlap. Also highly similar to TR:E1292351 (EMBL:AL023496) putative hydrolase SC1A6.03, fasta scores; E(): 0, 72.1% identity in 280 aa overlap.
 
 0.995
SCO1487
SC9C5.11c, pyrB, aspartate carbamoyltransferase, len: 326 aa; similar to SW:PYRB_PSEPU (EMBL:M97253) Pseudomonas putida aspartate carbamoyltransferase (EC 2.1.3.2) PyrB, 334 aa; fasta scores: opt: 902 z-score: 1064.2 E(): 0; 47.3% identity in 311 aa overlap. Contains 2x Pfam matches to entry PF00185 OTCace, Aspartate/ornithine carbamoyltransferase and match to Prosite entry PS00097 Aspartate and ornithine carbamoyltransferases signature; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
  
 
 0.973
SCO6416
Putative oxidoreductase; SC1A6.05, unknown, len: 340 aa; some similarity to e.g. TR:Q49598 (EMBL:U31567) Methanopyrus kandleri N5,N10-methylenetetrahydromethanopterin reductase (349 aa), fasta scores; opt: 207 z-score: 425.6 E(): 1.4e-16, 25.7% identityin 358 aa overlap.
 
     0.966
SCO3072
SCE25.13c, probable amino acid hydrolase, len: 400 aa; similar to SW:AMB2_BACST (EMBL:S67784) Bacillus stearothermophilus N-carbamyl-L-amino acid amidohydrolase (EC 3.5.1.-) AmaB, 409 aa; fasta scores: opt: 733 z-score: 804.8 E(): 0; 34.7% identity in 404 aa overlap.
 
 
 0.942
SCO6417
SC1A6.06, possible integral membrane transporter, len: 522 aa; some similarity to e.g. FUR4_YEAST P05316 saccharomyces cerevisiae uracil permease (633 aa), fasta sores; opt:478 z-score: 454.0 E(): 3.6e-18, 28.2% identity in 485 aa overlap. Contains PS00402 Binding-protein-dependent transport systems inner membrane component signature.
 
  
 0.886
SCO1488
Pyrimidine operon regulatory protein; Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.
  
 
 0.849
SCO1482
Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
  
 
 0.825
SCO1483
SC9C5.07c, pyrA, carbamoylphosphate synthetase large chain, len: 1102 aa; similar to SW:CARB_ECOLI (EMBL:V01500) Escherichia coli carbamoyl-phosphate synthase large chain (EC 6.3.5.5) CarB or PyrA, 1072 aa; fasta scores: opt: 3383 z-score: 3699.6 E(): 0; 55.0% identity in 1102 aa overlap. Contains 3x Pfam matches to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase (CPSase) and matches to Prosite entries 2x PS00866 Carbamoyl-phosphate synthase subdomain signature 1 and 2x PS00867 Carbamoyl-phosphate synthase subdomain signature.
  
 
 0.825
SCO1481
SC9C5.05c, pyrF, orotidine 5'-phosphate decarboxylase, len: 278 aa; similar to SW:DCOP_MYCTU (EMBL:Z80108) Mycobacterium tuberculosis orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) PyrF or UraA, 274 aa; fasta scores: opt: 800 z-score: 874.6 E(): 0; 51.1% identity in 282 aa overlap. Contains Pfam match to entry PF00215 OMPdecase, Orotidine 5'-phosphate decarboxylases and match to Prosite entry PS00156 Orotidine 5'-phosphate decarboxylase active site; Belongs to the OMP decarboxylase family. Type 2 subfamily.
  
  
 0.812
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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