STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO6425Hypothetical protein; SC1A6.14, probable transcriptional regulator, len: 256 aa; weak similarity to e.g. RHAR_ECOLI P09378 Escherichia coli L-rhamnose operon transcriptional regulator RhaR (312 aa), opt: 160 z-score: 207.2 E(): 0.0002, 29.5% identity in 105 aa overlap. Contains PS00041 Bacterial regulatory proteins, araC family signature, Pfam match to entry HTH_2 PF00165, Bacterial regulatory helix-turn-helix proteins, araC family, score 65.61, and probable helix-turn-helix motif at aa 174-195 (Score 1532, +4.40 SD). (256 aa)    
Predicted Functional Partners:
SCO1623
SCI41.06, unknown, len: 280 aa; similar to e.g. YX26_MYCTU hypothetical 30.6 KD protein CY274.26C, 283 aa; fasta scores: opt: 641 z-score: 744.6 E()0; 45.9% identity in 294 aa overlap.
  
    0.585
SCO6426
Hypothetical protein; SC1A6.15, unknown, len: 170 aa; similar to the C-terminus of several ABC transporter ATP binding proteins involved in iron transport, e.g. FEPC_ECOLI P23878 Escherichia coli ferric enterobactin transport ATP binding protein (271 aa), fasta scores; opt: 237 z-score: 425.9 E(): 1.3e-16, 38.7% identity in 106 aa overlap.
  
  
 0.536
SCO6423
SC1A6.12c, putative lipoate-protein ligase, len: 388 aa; some similarity inC-terM to LPLA_ECOLI P32099 Escherichia coli putative lipoate-protein ligase A (337 aa), fasta scores; opt: 162 z-score: 223.4E(): 2.5e-05, 27.8% identity in 252 aa overlap.
       0.525
SCO6424
SC1A6.13c, probable two-component system sensor protein, len: 331 aa; contains two potential transmembrane domains in the C-terminus; similar to e.g. DEGS_BACSU P13799 sensor protein DegS (EC 2.7.3.-) Bacillus subtilis (385 aa), fasta scores: opt: 316 z-score: 369.3 E(): 1.9e-13, 30.7% identity in 212 aa overlap and to TR:Q52558 (EMBL:U02041) Burkholderia solanacearum VrsA, 502 aa; fasta scores: opt: 398 Z-score: 416.9 E(): 1.4e-15; 31.724% identity in 290 aa overlap. Contains possible hydrophobic membrane spanning regions.
       0.525
SCO6427
SC1A6.16, probable integral membrane transport protein, len: 431 aa; weak similarity to e.g. Mycobacterium smegmatis TR:O31137 (EMBL:O31137) tetracycline-resistance determinant tetV (419 aa), fasta scores; opt: 389 z-score: 243.8 E(): 1.9e-06, 27.0% identity in 404 aa overlap.
       0.476
SCO2781
SCC105.12, hypothetical protein, len: 281 aa; similar to TR:CAB56689 (EMBL:AL121596) Streptomyces coelicolor hypothetical 28.7 kD protein, 259 aa; fasta scores: opt: 261 z-score: 302.6 E(): 2e-09; 34.9% identity in 255 aa overlap.
 
    0.444
SCO0459
Hypothetical protein SCF51A.37; SCF51A.37, unknown, len: 259 aa. Similar to Mycobacterium tuberculosis SW:YX26_MYCTU (EMBL; Z74024) hypothetical 30.6 KD protein CY274.26C (283 aa), fasta scores opt: 268 z-score: 318.2 E(): 2.3e-10 28.9% identity in 263 aa overlap.
 
    0.442
SCO4017
2SC10A7.21c, desR2, iron dependent repressor, len: 238 aa; highly similar to TR:CAB95905 (EMBL:AL359988) Streptomyces coelicolor iron repressor DesR, 230 aa; fasta scores: opt: 1140 z-score: 1122.3 E(): 0; 76.3% identity in 236 aa overlap and to SW:IDER_MYCTU (EMBL:U14191) Mycobacterium tuberculosis iron-dependent repressor IdeR, 230 aa; fasta scores: opt: 761 z-score: 754.0 E(): 0; 61.6% identity in 237 aa overlap. Contains Pfam match to entry PF01325 Fe_dep_repress, Iron dependent repressor.
   
  
 0.419
SCO4394
Iron repressor; SCD10.26, desR, probable iron repressor, len: 230 aa; identical to TR:Q54343 (EMBL:Z50049) Streptomyces lividans putative iron repressor DesR, 230 aa. Contains Pfam match to entry PF01325 Fe_dep_repress, Iron dependent repressor. Contains also a possible helix-turn-helix motif at residues 25..46 (+2.65 SD).
   
  
 0.419
SCO6370
SC4A2.06c, probable integral membrane protein, len: 344 aa; slight similarity to e.g. TR:O34524 (EMBL:AF027868) B. subtilis putative transporter yocS (321 aa), fasta scores; opt: 141 z-score: 232.8 E(): 1e-05, 23.1% identity in 324 aa overlap.
   
    0.400
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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