STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO6484SC9C7.20, conserved hypothetical protein, len: 860aa; similar to many hypothetical proteins egs. TR:O86875 (EMBL:U22894) from Streptomyces lividans (547 aa) fasta scores; opt: 1000, z-score: 738.2, E(): 0, (40.0% identity in 497 aa overlap) and TR:O86807 (EMBL:AL031031) from Streptomyces coelicolor (916 aa) fasta scores; opt: 358, z-score: 316.9, E(): 2.3e-10, (27.2% identity in 779 aa overlap). Also contains a short region of similarity to TR:Q53897 (EMBL:X60316) AbaA regulatory locus from Streptomyces coelicolor (192 aa) fasta scores; opt: 108, z-score: 223.2, E(): 3.8e-05, (38.5% id [...] (860 aa)    
Predicted Functional Partners:
SCO3549
Putative anti-sigma factor antagonist; Positive regulator of sigma-B activity. Non-phosphorylated RsbV binds to RsbW, preventing its association with sigma-B. When phosphorylated, releases RsbW, which is then free to complex with and inactivate sigma-B (By similarity).
 
   0.802
SCO5933
SC7H1.03c, possible membrane protein, len: 391 aa; C-terminal part similar to TR:Q9L0E7 (EMBL:AL161803) Streptomyces coelicolor hypothetical protein SCD31.20, 181 aa; fasta scores: opt: 592 Z-score: 665.9 E(): 1.8e-29; 53.514% identity in 185 aa overlap. Contains possible hydrophobic membrane spanning regions. Contains PS00213 Lipocalin signature, though this may be spurious.
  
     0.741
SCO7573
SC5F1.27c, probable anti-sigma factor antagonist, len: 114 aa; similar to SW:RSBV_STRCO (EMBL:AF134889) Streptomyces coelicolor anti-sigma factor B antagonist BldG, 113 aa; fasta scores: opt: 320 z-score: 436.5 E(): 8.8e-17; 49.5% identity in 99 aa overlap. Contains Pfam match to entry PF01740 STAS, STAS domain; Belongs to the anti-sigma-factor antagonist family.
 
   0.739
SCO3067
SCE25.08c, putative anti anti sigma factor, len: 125 aa; identical to previously sequenced TR:CAB55835 (EMBL:AJ249581) Streptomyces coelicolor A3(2) putative anti anti sigma factor, 125 aa. Contains Pfam match to entry PF01740 SpoIIAA, SpoIIAA family; Belongs to the anti-sigma-factor antagonist family.
 
   0.686
SCO1327
2SCG61.09, possible integral membrane protein, len: 387 aa; similar to many predicted integral membrane protein especially others from Streptomyces coelicolor e.g. TR:CAB69689 (EMBL:AL137165) putative integral membrane protein (375 aa) fasta scores; opt: 481, z-score: 562.8, E(): 7.2e-24, 35.7% identity in 387 aa overlap. Contains possible membrane-spanning hydrophobic regions.
  
     0.657
SCO6483
SC9C7.19, probable efflux protein, len: 815aa; similar to many, several of which are involved in toxin; Belongs to the major facilitator superfamily.
       0.572
SCO7325
SC4G10.04c, anti-sigma factor antagonist, len: 130 aa. Similar to many including: Bacillus licheniformis SW:SP21_BACLI (EMBL:M25260) anti-sigma F factor antagonist (stage II sporulation protein AA) (117 aa), fasta scores opt: 187 z-score: 252.1 E(): 1.4e-06 28.4% identity in 109 aa overlap and Streptomyces coelicolor SW:RSBV_STRCO (EMBL:AF134889) anti-sigma factor antagonist, BldG (113 aa), fasta scores opt: 196 z-score: 263.7 E(): 3.2e-07 26.5% identity in 102 aa overlap. Contains a Pfam match to entry PF01740 SpoIIAA, SpoIIAA family.
 
   0.545
SCO5747
SC7C7.02c, possible regulatory protein, len: 916 aa; N-terminus is similar to S. coloicolor TR:Q53897 (EMBL:X60316) AbaA ORFA (192 aa), fasta scores; opt: 248 z-score: 257.6 E(): 4.1e-07, 34.2% identity in 187 aa overlapC-terminus is similar to several RsbU homologs e.g. Bacillus licheniformis TR:O50229 (EMBL:AF034567) putative sigma B regulator similar to B. subtilis RsbU phosphatase (335 aa), fasta scores; opt: 232 z-score: 196.5 E(): 0.001, 26.3% identity in 240 aa overlap.
 
 
0.543
SCO6485
Hypothetical protein SC9C7.21; SC9C7.21, unknown, len: 240 aa.
 
     0.516
SCO0542
SCF11.22, hypothetical regulatory protein, len: 877 aa; similar to various hypothetical proteins, e.g. TR:CAB44382 (EMBL:AL078610) Streptomyces coelicolor hypothetical 66.2 KD protein, 634 aa; fasta scores: opt: 1072 z-score: 1125.7 E(): 0; 38.2% identity in 678 aa overlap and to SW:RSBU_BACSU (EMBL:L35574) Bacillus subtilis sigma factor sibG regulation protein RsbU, 335 aa; fasta scores: opt: 211 z-score: 225.9 E(): 3.2e-05; 25.6% identity in 250 aa overlap. Contains Pfam matches to entries PF00989 PAS, PAS domain and PF01590 GAF, GAF domain.
 
  
0.502
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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