STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO6520SC5C7.05, probable RNA polymerase sigma factor, len: 266 aa; simlar to S. coelicolor sigma factors of the SigB subfamily e.g. TR:O52313 (EMBL:AF036131) putative RNA polymerase secondary sigma factor SigG (263 aa), fasta scores; opt: 1258 z-score: 1540.5 E(): 0, 72.9% identity in 251 aa overlap, and to RPOF_STRAU RNA polymerase sigma-F factor (297 aa), fasta scores; opt: 713 z-score: 858.3 E(): 0, 42.6% identity in 312 aa overlap. Possible alternative start 216 bp upstream, not supported by FramePlot. Contains helix-turn-helix motif at aa 228-249 (Score 2104, +6.35 SD) and Pfam match to [...] (266 aa)    
Predicted Functional Partners:
SCO5747
SC7C7.02c, possible regulatory protein, len: 916 aa; N-terminus is similar to S. coloicolor TR:Q53897 (EMBL:X60316) AbaA ORFA (192 aa), fasta scores; opt: 248 z-score: 257.6 E(): 4.1e-07, 34.2% identity in 187 aa overlapC-terminus is similar to several RsbU homologs e.g. Bacillus licheniformis TR:O50229 (EMBL:AF034567) putative sigma B regulator similar to B. subtilis RsbU phosphatase (335 aa), fasta scores; opt: 232 z-score: 196.5 E(): 0.001, 26.3% identity in 240 aa overlap.
 
 
 0.878
SCO4184
SCD66.21, amfC, aerial mycelium formation, len: 222 aa; identical to previously sequenced TR:Q54191 (EMBL:D63677) Streptomyces coelicolor aerial micelium formation AmfC, 222 aa.
  
 
 
 0.861
SCO5244
2SC7G11.06c, prs1, anti-sigma factor, len: 137 aa; identical to previously sequenced TR:Q9R3X8 (EMBL:AJ249450) Streptomyces coelicolor A3(2) putative regulator of Sig1, Prs1 protein or UshX, 137 aa.
 
 
 0.842
SCO4654
DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 
 
 0.800
SCO4655
DNA-directed RNA polymerase beta' chain (fragment); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 
 
 0.779
SCO3066
SCE25.07c, putative regulator of Sig15, len: 170 aa; identical to previously sequenced TR:CAB55834 (EMBL:AJ249581) Streptomyces coelicolor A3(2) putative regulator of Sig15, 170 aa.
  
 
 0.743
SCO7328
Putative regulatory protein; SC4G10.07c, possible regulatory protein, len: 144 aa. Highly similar to Streptomyces fradiae TR:Q9Z9I5 (EMBL:AB024056) beta-lactamase regulator protein (139 aa), fasta scores opt: 530 z-score: 661.7 E(): 2.2e-29 61.5% identity in 122 aa overlap and Streptomyces coelicolor TR:Q9X7S3 (EMBL:AL049863) putative regulator protein, SC5H1.15C (151 aa), fasta scores opt: 178 z-score: 231.0 E(): 2.1e-05 30.8% identity in 130 aa overlap.
  
 
 0.743
SCO7313
Hypothetical protein SC5F8.23; SC5F8.23, unknown, len: 148 aa. Weakly similar to several putative regulatory proteins e.g. Streptomyces coelicolor A3(2) TR:Q9RIS7(EMBL:AJ249581) putative regulator of sig15 (170 aa), fasta scores opt: 144 z-score: 184.4 E(): 0.0084 36.1% identity in 133 aa overlap and Streptomyces coelicolor TR:Q9RD41(EMBL:AL133422) SCM1.01C (147 aa), fasta scores opt: 225 z-score: 281.4 E(): 3.3e-08 36.6% identity in 131 aa overlap.
  
  
 0.684
SCO3549
Putative anti-sigma factor antagonist; Positive regulator of sigma-B activity. Non-phosphorylated RsbV binds to RsbW, preventing its association with sigma-B. When phosphorylated, releases RsbW, which is then free to complex with and inactivate sigma-B (By similarity).
 
 
 0.662
SCO3208
SCE8.01, possible secreted protein, len: 432 aa; similar to TR:CAC44281 (EMBL:AL596030) Streptomyces coelicolor hypothetical protein SCBAC17F8.09, 436 aa; fasta scores: opt: 555 Z-score: 578.7 E(): 1.3e-24; 33.991% identity in 456 aa overlap. Contains a possible N-terminal signal sequence.
  
  
 0.660
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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