STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO6540Hypothetical protein SC5C7.25; SC5C7.25, unknown, len: 101 aa; similar to several genes predicted to be pterin-4a-carbinolamine dehydratases e.g. Aquifex aeolicus TR:O66462 (EMBL:AE000671) phhB (99 aa), fasta scores; opt: 165 z-score: 280.7 E(): 2.2e-08, 30.3% identity in 89 aa overlap. (101 aa)    
Predicted Functional Partners:
SCO6541
SC5C7.26, unknown, len: 248 aa; similar to hypothetical proteins and to TR:Q54529 (EMBL:U10405) Streptomyces purpurascens RdmD gene (required for modification on 10-position of aklavinone during anthracycline antibiotic synthesis) (237 aa), fasta scores; opt: 162 z-score: 217.3 E(): 7.4e-05, 36.1% identity in 158 aa overlap.
       0.875
SCO6539
SC5C7.24c, hypothetical protein, len: 272 aa; similar to TR:Q985F1 (EMBL:AP003012) Rhizobium loti (Mesorhizobium loti) MLL7704 protein, 270 aa; fasta scores: opt: 786 Z-score: 877.1 E(): 3.2e-41; 48.638% identity in 257 aa overlap.
       0.788
SCO4403
Putative formyltetrahydrofolate deformylase (fragment); Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).
     
 0.745
SCO6542
SC5C7.27, possible secreted glycosyl hydrolase len: 631 aa; similar to two hypothetical proteins from B. subtilis TR:O31526 (EMBL:Z99107) yesW (620 aa), fasta scores; opt: 2404 z-score: 2009.8 E(): 0, 57.7% identity in 620 aa overlap and TR:O31527 (EMBL:Z99107) yesX (612 aa), fasta scores; opt: 1856 z-score: 1984.4 E(): 0, 54.4% identity in 599 aa overlap. Contains possible N-terminal signal sequence. Similar to TR:Q9AF09 (EMBL:AY026755) rhamnogalacturonan lyase from Pseudomonas cellulosa (881 aa) fasta scores; opt: 2392, Z-score: 2482.1, 59.091% identity (61.043% ungapped) in 594 aa o [...]
       0.693
SCO1715
Putative homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.
  
  
 0.687
SCO3615
SC66T3.26c, ask, probable aspartokinase, len: 425 aa; highly similar to many e.g. SW:AKAB_MYCSM (EMBL:Z17372), ask, Mycobacterium smegmatis aspartokinase (421 aa), fasta scores; opt: 1839 z-score: 1990.8 E(): 0, 67.4% identity in 427 aa overlap. Homologous genes encode both the alpha and beta subunits of ask by using alternative initiation codons. Codon 253 represents the equivalent position in this sequence, by similarity. Contains Pfam match to entry PF00696 aakinase, Aspartate kinases, Glutamate kinases and Gamma glutamate phospho-reductases and PS00324 Aspartokinase signature.
      
 0.584
SCO1998
SC7H2.12c, rpsA, 30S ribosomal protein S1, len: 502aa; similar to many eg. SW:RS1_ECOLI rpsA, 30S ribosomal protein S1 from Escherichia coli (557 aa) fasta scores; opt: 1016, z-score: 1019.6, E(): 0, (39.8% identity in 452 aa overlap). Also similar to TR:O06147 (EMBL:Z95554) 30S ribosomal protein S1 from Mycobacterium tuberculosis (481 aa) fasta scores; opt: 2420, z-score: 2422.2, E(): 0, (79.1% identity in 492 aa overlap). Contains four Pfam matches to entry PF00575 S1, S1 RNA binding domain. Also contains possible coiled-coil region around 400-410aa.
  
  
 0.579
SCO4366
Putative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
      
 0.562
SCO6537
SC5C7.22c, unknown, len: 287 aa; similar to S. coelicolor hypothetical protein SC4G2.03 (E(): 2.2e-08, 29.2% identity in 257 aa overlap). Contains possible helix-turn-helix motif at aa 29-50 (Score 1251, +3.45 SD).
       0.560
SCO2927
SCE19A.27c, probable 4-hydroxyphenylpyruvate dioxygenase, len: 381 aa; highly similar to many e.g. SW:HPPD_STRAW (EMBL:U11864) Streptomyces avermitilis 4-hydroxyphenylpyruvate dioxygenase (380 aa), fasta scores; opt: 2347 z-score: 2634.5 E(): 0, 91.9% identity in 381 aa overlap. Similar to TR:Q9Z4X7 (EMBL:AL035640) S. coelicolor probable 4-hydroxyphenylpyruvic acid dioxygenase (325 aa) (36.4% identity in 330 aa overlap); Belongs to the 4HPPD family.
  
  
 0.553
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.