STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO6546SC5C7.31c, probable secreted cellulase, len: 973 aa; N-terminus is similar to the cellulose binding domain of e.g. GUN4_THEFU endoglucanase E-4 precursor (880 aa), fasta scores; opt: 341 z-score: 352.0 E(): 2.3e-12, 43.7% identity in 103 aa overlap. C-terminus is similar to many cellulases e.g. GUXB_CELFI exoglucanase B precursor (1090 aa), fasta scores; opt: 2997 z-score: 2688.8 E(): 0, 61.4% identity in 699 aa overlap. Contains probable N-terminal signal sequence and Pfam match to entry PF00553 CBD_1, Cellulose binding domain, score 122.30, E-value 2.4e-34 near N-terminus. (973 aa)    
Predicted Functional Partners:
SCO6545
SC5C7.30c, probable secreted cellulase, len: 890 aa; similar to TR:D1029971 (EMBL:AB015511) Aspergillus aculeatus avicelase III (856 aa), fasta scores; opt: 2099 z-score: 1414.5 E(): 0, 44.5% identity in 845 aa overlap, and to many others e.g. GUNA_MICBI endoglucanase A precursor (EC 3.2.1.4) (456 aa), fasta scores; opt: 416 z-score: 340.7 E(): 9.9e-12, 28.5% identity in 449 aa overlap (strongest in the cellulose-binding domain). Contains probable N-terminal signal sequence and Pfam match to entry PF00553 CBD_1, Cellulose binding domain, score 171.70, E-value 8.5e-49 at C-terminus.
 
   
0.802
SCO6548
SC5C7.33, probable secreted cellulase, len: 579 aa; similar to many, e.g. TR:Q60029 (EMBL:U18978) beta-1,4-exocellulase precursor (596 aa), fasta scores; opt: 2131 z-score: 2323.9 E(): 0, 62.1% identity in 585 aa overlap. Contains possible N-terminal signal sequence, PS00655 Glycosyl hydrolases family 6 signature 1 and Pfam match to entry PF00553 CBD_1, Cellulose binding domain, score 161.20, E-value 9.8e-46 near C-terminus.
 
   
0.787
SCO6234
SC2H4.16, manA, probable secreted beta-mannosidase, len: 384 aa; 94.5% identical to MANA_STRLI mannan endo-1,4-beta-mannosidase precursor (363 aa). Contains PS00659 Glycosyl hydrolases family 5 signature and Pfam match to entry PF00150 cellulase, Cellulase (glycosyl hydrolase family 5), score 104.70, E-value 1.8e-27.
 
     0.750
SCO0643
SCF91.03c, possible secreted cellulose-binding protein, len: 228 aa. Similar to several including: Streptomyces coelicolor TR:CAB50949 (EMBL:AL096849) putative secreted cellulose-binding protein SCI11.23 (356 aa), fasta scores opt: 349 z-score: 417.9 E(): 6.7e-16 32.2% identity in 227 aa overlap. Also weakly similar to chitin-binding proteins e.g. Streptomyces olivaceoviridis TR:Q54501 (EMBL:X78535) chitin binding protein precursor (201 aa), fasta scores opt: 203 z-score: 249.8 E(): 1.5e-06 29.3% identity in 222 aa overlap. Contains a possible N-terminal signal sequence.
  
   
 0.732
SCO6542
SC5C7.27, possible secreted glycosyl hydrolase len: 631 aa; similar to two hypothetical proteins from B. subtilis TR:O31526 (EMBL:Z99107) yesW (620 aa), fasta scores; opt: 2404 z-score: 2009.8 E(): 0, 57.7% identity in 620 aa overlap and TR:O31527 (EMBL:Z99107) yesX (612 aa), fasta scores; opt: 1856 z-score: 1984.4 E(): 0, 54.4% identity in 599 aa overlap. Contains possible N-terminal signal sequence. Similar to TR:Q9AF09 (EMBL:AY026755) rhamnogalacturonan lyase from Pseudomonas cellulosa (881 aa) fasta scores; opt: 2392, Z-score: 2482.1, 59.091% identity (61.043% ungapped) in 594 aa o [...]
  
     0.721
SCO5931
SC10A5.36c, xlnA, xylanase A precursor, partial CDS, len >383 aa; overlaps and extends ORF from neighbouring cosmid SC7H1.01c; almost identical to XYNA_STRLI P26514 endo- 1,4-beta-xylanase a precursor (477 aa) (99.2% identity in 383 aa overlap). Conatains PS00591 Glycosyl hydrolases famil y 10 active site and Pfam match to entry glycosyl_hydro3 PF 00331, Glycosyl hydrolases family 10, score 183.41. Also si milar in part to S. coelicolor SC7H1.02, abfB, arabinofuran osidase (E(): 1.4e-35, 58.4% identity in 149 aa overlap); SC7H1.01c, xlnA, xylanase A precursor, partial CDS, len >147 aa; [...]
 
   
 0.712
SCO0535
SCF11.15, possible hydrolase (putative secreted protein), len: 473 aa; similar to TR:AAD30364 (EMBL:AF078737) Caldicellulosiruptor sp. Tok7B.1 xylanase/endoglucanase, CelB, 1426 aa; fasta scores: opt: 484 z-score: 506.2 E(): 7.9e-21; 33.0% identity in 327 aa overlap. Contains a Pfam match to entry PF00942 CBD_3, cellulose binding domain. Contains possible n-terminal region signal sequence peptide.
 
 0.707
SCO2292
SCC75A.38, xlnB, secreted endo-1,4-beta-xylanase B (xylanase B), len: 335 aa. Almost identical to Streptomyces lividans SW:XYNB_STRLI(EMBL:M64552) endo-1,4-beta-xylanase B precursor (xylanase B) (EC 3.2.1.8) (334 aa), fasta scores opt: 2266 z-score: 2249.3 E():0 98.2% identity in 335 aa overlap. Also similar to Streptomyces coelicolor TR:CAB52919 (EMBL:AL109949) endo-1,4-beta-xylanase, XlnC (241 aa), fasta scores opt: 1087 z-score: 970.6 E():0 71.9% identity in 224 aa overlap and to the adjoining CDS on this cosmid, AxeA, (335 aa), fasta scores opt: 652 z-score: 585.8 E(): 2.9e-27 56.2 [...]
 
     0.694
SCO0765
SCF81.24c, cel1, secreted endoglucanase, len: 747 aa; highly similar to SW:GUN1_STRRE (EMBL:X65616) Streptomyces reticulii cellulase 1 precursor (EC 3.2.1.4) (endoglucanase) (endo-1,4-beta-glucanase) (avicelase) Cel1, 746 aa; fasta scores: opt: 4213 z-score: 4621.9 E(): 0; 80.3% identity in 747 aa overlap. Contains two matches to Pfam entries PF00759 Glyco_hydro_9, Glycosyl hydrolase family 9 and to Prosite entry PS00698 Glycosyl hydrolases family 9 active sites signature 2. Also contains N-terminal region signal peptide sequence and a possible helix-turn-helix motif at residues 119..1 [...]
  
   
 0.676
SCO1880
SCI39.27c, probable secreted pectate lyase, len: 444 aa; similar to SW:PEL_BACS (EMBL:X74880) Bacillus subtilis pectate lyase precursor (EC 4.2.2.2) Pel, 420 aa; fasta scores: opt: 1127 Z-score: 1249.8 bits: 240.3 E(): 5e-62; 42.431% identity in 436 aa overlap. Contains 2x Pfam matches to entry PF00544 pec_lyase, Pectate lyase. Contains also possible N-terminal region signal peptide sequence.
  
   
 0.652
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.