STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO6557SC4B5.07c, possible neuraminidase (putative secreted protein), len: 648 aa; similar to several e.g. TR:D1001316 (EMBL:D01045) neuraminidase from Micromonospora viridifaciens (647 aa) fasta scores; opt: 286, z-score: 289.0, E(): 8.4e-09, (30.4% identity in 598 aa overlap). Contains possible N-terminal region signal peptide sequence. (648 aa)    
Predicted Functional Partners:
SCO0033
SCJ4.14c, possible secreted neuraminidase (sialidase), len: 748 aa; similar to many, both prokaryote and eukaryote, egs. SW:NANH_MICVI sialidase precusor from Micromonospora viridifaciens (647 aa) fasta scores; opt: 274, z-score: 299.9, E(): 2.4e-09, (28.6% identity in 587 aa overlap) and TR:O35657 (EMBL:Y11412) G9 sialidase precusor from Mus musculus (Mouse) (409 aa) fasta scores; opt: 325, z-score: 358.5, E(): 1.3e-12, (26.6% identity in 425 aa overlap). Also similar to TR:Q9ZBW1 (EMBL:AL034443) putative neuraminidase from Streptomyces coelicolor (648 aa) fasta scores; opt: 479, z-sc [...]
  
  
 
0.926
SCO0274
SCF85.02, possible alpha-galactosidase, len: 499 aa. Similar to many alpha galactosidases e.g. Thermus aquaticus TR:AAD32628(EMBL; AF135399) alpha-galactosidase (476 aa), fasta scores opt: 1329 z-score: 1530.0 E(): 0 45.8% identity in 487 aa overlap.
  
  
  0.912
SCO0284
SCF85.12, possible secreted alpha-galactosidase, len: 680 aa. Highly similar to many Eukaryotic alpha-galactosidases over the first 415 aa, e.g. Coffea arabica (Coffee) alpha-galactosidase precursor (EC 3.2.1.22) (melibiase) (378 aa),opt: 1323 z-score: 1416.9 E(): 0; 54.5% identity in 354 aa overlap, in addition to Saccharopolyspora erythraea (Streptomyces erythraeus)alpha galactosidase precursor MelA (428 aa),fasta scores opt: 623 z-score: 668.6 E(): 6.9e-30 50.6% identity in 427 aa overlap. Contains a PS00512 Alpha-galactosidase signature, a PS00599 Aminotransferases class-II pyridox [...]
     
  0.900
SCO0541
SCF11.21, probable alpha-galactosidase, len: 441 aa; similar to SW:AGAL_BACSU (EMBL:AF008220) Bacillus subtilis alpha-galactosidase (EC 3.2.1.22) (Melibiase) MelA, 432 aa; fasta scores: opt: 1068 z-score: 1240.5 E(): 0; 39.3% identity in 427 aa overlap.
     
  0.900
SCO2430
SCC24.01, possible sugar hydrolase (fragment) (putative secreted protein), len: >407 aa; similar to C-terminal region of SW:BGAL_ASPNG (EMBL:L06037) Aspergillus niger beta galactosidase precursor (EC 3.2.1.23) LacA, 1006 aa; fasta scores: opt: 214 z-score: 223.7 E(): 5e-05; 27.1% identity in 321 aa overlap; SCC42.11, probable secreted beta-galactosidase (fragment), len: >555 aa; similar to SW:BGAL_ASPNG (EMBL:L06037) Aspergillus niger beta-galactosidase precursor (EC 3.2.1.23) LacA, 1006 aa; fasta scores: opt: 413 z-score: 403.4 E(): 5.4e-15; 24.3% identity in 608 aa overlap. Contains [...]
 
 0.638
SCO5689
SC5H4.13, probable beta-galactosidase, len: 656 aa; similar to SW:BGAL_BACST (EMBL:M13466) Bacillus stearothermophilus beta-galactosidase I (EC 3.2.1.23) (lactase) BgaB, 672 aa; fasta scores: opt: 1761 z-score: 2065.7 E(): 0; 41.3% identity in 634 aa overlap and to TR:CAB76326 (EMBL:AL158061) Streptomyces coelicolor probable beta-galactosidase SC6D11.03c, 681 aa; fasta scores: opt: 1739 z-score: 1719.0 E(): 0; 46.0% identity in 670 aa overlap.
  
 0.591
SCO6347
Beta-galactosidase; SC3A7.15, probable beta-galactosidase, len: 595; similar to many e.g. TR:O31341 (EMBL:D88750) beta-galactosidase (EC 3.2.1.23) (lactase) from Bacillus circulans (586 aa), fasta scores; opt: 1648 z-score: 1500.8 E(): 0, 43.0% identity in 584 aa overlap., Contains PS01182 Glycosyl hydrolases family 35 putative active site.
  
 0.591
SCO7407
SC6D11.03c, probable beta-galactosidase, len: 681 aa. Similar to many beta-galactosidases e.g. Bacillus stearothermophilus SW:BGAL_BACST(EMBL:M13466) beta-galactosidase I (EC 3.2.1.23), BgaB, (672 aa), fasta scores opt: 1816 z-score: 2079.7 E(): 0 43.2% identity in 666 aa overlap.
  
 0.591
SCO0003
Putative DNA-binding protein; SC8E7.41c, possible DNA-binding protein, len: 783 aa. Contains a putative helix-turn-helix motif situated between residues 69..90 (+3.17 SD).
   
    0.559
SCO2863
SCE20.37, possible helicase, len: 945 aa. Weakly similar to Saccharomyces cerevisiae (Baker's yeast) TR:Q06683(EMBL:U32517) DEAD box family helicase family protein (689 aa), fasta scores opt: 455 z-score: 511.5 E(): 4.1e-21 27.2% identity in 357 aa overlap. Also weakly similar to several bacteriophage proteins including: Lactococcus bacteriophage (isolate 7-9) SW:V51K_BPL79 (EMBL:M36388) 51.5 KD protein which may play a role in either regulating bacteriophage replication or bacteriophage specific genes (452 aa), fasta scores opt: 407 z-score: 460.0 E(): 3.1e-18 27.4% identity in 328 aa [...]
   
    0.559
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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