STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO6619SC1F2.16c, probable dehydrogenase, len: 276 aa; similar to many e.g. TR:O24479 (EMBL:U89510) B-keto acyl reductase from Hordeum vulgare (barley) (325 aa), fasta scores; opt: 316 z-score: 468.7 E(): 7.2e-19, 36.4% identity in 214 aa overlap and HETN_ANASP ketoacyl reductase hetN (287 aa), fasta scores; opt: 343 z-score: 416.6 E(): 5.8e-16, 36.8% identity in 220 aa overlap. Contains PS00061 Short-chain dehydrogenases reductases to entry PF00106 adh_short, Alcohol /other dehydrogenases, short chain type, score 166.30, E-value 5.1e-46; Belongs to the short-chain dehydrogenases/reductases ( [...] (276 aa)    
Predicted Functional Partners:
SCO6618
Hypothetical protein SC1F2.15c; SC1F2.15c, unknown, len: 226 aa.
       0.675
SCO0111
SCJ11.40, probable oxidoreductase, len: 753 aa; similar to many egs. TR:O32457 (EMBL:D87924) ORF7 from the putative polyketide synthase cluster of Actinomadura hibisca (246 aa) fasta scores; opt: 480, z-score: 498.5, E(): 2.1e-20, (38.3% identity in 248 aa overlap) and TR:Q54810 (EMBL:L35560) reductase from the doxorubicin polyketide synthase cluster of Streptomyces peucetius (251 aa) fasta scores; opt: 408, z-score: 425.7, E(): 2.4e-16, (33.7% identity in 243 aa overlap). Contains Pfam matches to entry PF00106 adh_short, short chain dehydrogenase and to entry PF00678 adh_short_C2, Sho [...]
  
 
   0.651
SCO3316
SCE68.14c, probable dehydrogenase, len: 258 aa; similar to many e.g. SW:DHG3_BACME (EMBL:D10625), gdhIII, Bacillus megaterium glucose 1-dehydrogenase III (261 aa), fasta scores; opt: 424 z-score: 446.0 E(): 1.6e-17,32.4% identity in 253 aa overlap. Similar to many others from S.coelicolor e.g. TR:O88068 (EMBL:AL031541), SCI35.33c, probable dehydrogenase (260 aa) (33.5% identity in 254 aa overlap). Contains Pfam matches to entry PF00106 adh_short, short chain dehydrogenase and entry PF00678 adh_short_C2, Short chain dehydrogenase/reductase C-terminus. Contains PS00061 Short-chain dehydr [...]
  
 
   0.634
SCO0138
SCJ33.02, possible oxidoreductase, len: 257 aa. Similar to many other putative oxidoreductases including: Streptomyces cinnamonensis SW:DHKR_STRCM (EMBL; Z11511) monensin polyketide synthase putative ketoacyl reductase (EC 1.3.1.-) (261 aa), fasta scores opt: 386 z-score: 426.3 E(): 2.2e-16 35.8% identity in 260 aa overlap. Contains a Prosite hit to PS00061 Short-chain dehydrogenases/reductases family signature and a Pfam match to entry PF00106 adh_short, short chain dehydrogenase.
  
 
   0.601
SCO6620
SC1F2.17, hypothetical protei, len: 143 aa; similar to hypothetical proteins e.g. M. tuberculosis TR:P71885 (EMBL:Z79702) MTCY3G12.07C (163 aa), fasta scores; opt: 171 z-score: 244.4 E(): 2.3e-06, 36.0% identity in 114 aa overlap.
       0.541
SCO5237
SC7E4.34c, probable oxidoreductase, len: 250 aa; highly similar to TR:Q9RKS8 (EMBL:AL132824) Streptomyces coelicolor reductase SCAH10.29, 262 aa; fasta scores: opt: 807 z-score: 863.1 E(): 0; 52.4% identity in 252 aa overlap and to SW:VER1_ASPPA (EMBL:M91369) Aspergillus parasiticus versicolorin reductase (EC 1.1.-.-) Ver1, 262 aa; fasta scores: opt: 469 z-score: 506.7 E(): 9.4e-21; 39.2% identity in 255 aa overlap. Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase and PF00678 adh_short_C2, Short chain dehydrogenase/reductase C-terminus.
  
 
   0.531
SCO6616
SC1F2.13c, putative secreted protein, len: 476 aa; similar to several proteins from M. tuberculosis e.g. TR:O05897 (EMBL:Z95121) hypothetical protein MTCY20B11.29 (462 aa), fasta scores; opt: 573 z-score: 448.5 E(): 9.7e-18, 32.3% identity in 400 aa overlap. Contains possible N-terminal signal sequence.
  
    0.513
SCO6617
Hypothetical protein SC1F2.14c; SC1F2.14c, unknown, len: 109 aa.
       0.513
SCO0234
SCJ9A.13, probable oxidoreductase, len: 153aa; similar to many eg. SW:DHG_BACME glucose dehydrogenase from Bacillus megaterium (261 aa) fasta scores; opt: 252, z-score: 277.8, E(): 4.1e-08, (44.0% identity in 100 aa overlap). Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase.
  
 
   0.508
SCO1815
Probable 3-oxacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  
 
   0.503
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.