STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
SCO6626Putative protein kinase; SC1F2.23, unknown, len: 1557 aa; some simlarity to several protein kinases e.g. ABL_MLVAB tyrosine-protein kinase transforming protein from Abelson murine leukemia virus (746 aa), fasta scores; opt: 84 z-score: 234.0 E(): 8.6e-06, 24.7% identity in 364 aa overlap. Contains PS00107 Protein kinases ATP-binding region signature, Pfam match to entry PF00069 pkinase, Eukaryotic protein kinase domain, score 18.10, E-value 0.00062 and possible helix-turn-helix motif at aa 1027-1048 (Score 1753, +5.16 SD). (1557 aa)    
Predicted Functional Partners:
SCO6627
Hypothetical protein; SC4G2.01, unknown, partial CDS, len: >378 aa; continuation of SC1F2.24; SC1F2.24, unknown, partial CDS, len: >862 aa; contains short segment of similarity to a Helicobacter pylori gene described as TR:O26046 (EMBL:AE000649) type IIS restriction enzyme R and M protein (1279 aa), fasta scores; opt: 92 z-score: 267.0 E(): 1.3e-07, 30.5% identity in 118 aa overlap. Also contains PS00092 N-6 Adenine-specific DNA methylases signature and probable coiled-coil from a 5-39. Note that this CDS is relatively more AT rich (approx 60% GC) than the genomic average (72%).
 
     0.955
SCO6635
Bacteriophage (phiC31) resistance gene pglY; SC4G2.09, pglY, len: 1294 aa; 99.8% identical to S. coelicolor TR:Q53942 (EMBL:L37531) bacteriophage (phiC31) resistance gene pglY (1294 aa). Contains PS00017 ATP.
 
   
 0.893
SCO6636
Bacteriophage (phiC31) resistance gene pglZ; SC4G2.10, pglZ, len: 974 aa; 98.9% identical to S. coelicolor TR:Q53943 (EMBL:L37531) bacteriophage (phiC31) resistance gene pglZ (974 aa).
 
     0.892
SCO6639
SC4G2.13, probable ATP/GTP binding protein, len: 449 aa; similar to TR:O26411 (EMBL:AE000816) hypothetical protein MTH311 (Methanobacterium thermoautotrophicum) (411 aa), fasta scores; opt: 596 z-score: 528.7 E(): 3.3e-22, 30.5% identity in 393 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop).
 
     0.816
SCO6640
SC4G2.14, probable ATP-dependent helicase, len: 731 aa; similar to many predicted helicases e.g. C-terminuis of LHR_ECOLI probable ATP-dependent helicase LHR (1538 aa), fasta scores; opt: 332 z-score: 570.0 E(): 1.7e-24, 29.3% identity in 638 aa overlap. Contains PS00017 ATP.
 
     0.814
SCO5331
SC6G9.02, possible DNA methylase, len: 1200 aa; highly similar to TR:O86561 (EMBL:AL031350) (71.5% identity in 867 aa overlap) and TR:O86674 (EMBL:AL031371) (90.8% identity in 370 aa overlap) which together constitute a single hypothetical protein split across the join between S.coelicolor cosmids 1F2 and 4G2. It has very weak similarity to DNA methylases, which combined with the presence of a DNA methylases signature and possible DNA-binding region (helix-turn-helix) provides circumstantial evidence of DNA-methylase function. The central third of the CDS is relatively AT rich. Contain [...]
 
     0.812
SCO2712
SCC61A.33, possible membrane protein, len: 239aa; weakly similar to TR:Q9X4U6 (EMBL:AF118389) from cps locus of Streptococcus suis serotype 2 (229 aa) fasta scores; opt: 161, z-score: 172.0, E(): 0.04, 28.4% identity in 176 aa overlap. Contains possible membrane-spanning hydrophobic regions.
  
 
 
 0.677
SCO4675
SCD40A.21c, hypothetical protein, len: 302 aa; similar to TR:Q9XD94 (EMBL:AF106004) Streptomyces coelicolor hypothetical 34.1 kD protein, 304 aa; fasta scores: opt: 850 z-score: 992.1 E(): 0; 45.0% identity in 300 aa overlap. Contains match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign.
  
     0.633
SCO0826
SCF43A.16, hypothetical protein, len: 266 aa; unknown function, shares short internal regions of similarity with several methyltransferases e.g. TR:O82434 (EMBL:AF053766) Nicotiana tabacum S-adenosyl-methionine cycloartenol-C24-methyltransferase (349 aa), fasta scores; opt: 165 z-score: 206.0 E(): 0.00038, 29.8% identity in 104 aa overlap. Weakly similar to part of SC1E6.19C (EMBL:AL033505) S.coelicolor hypothetical protein (273 aa) (35.1% identity in 131 aa overlap).
  
     0.629
SCO2714
SCC61A.35, possible secreted protein, len: 395aa; contains a possible non-cleavable N-terminal signal sequence; Belongs to the glycosyl hydrolase 26 family.
  
     0.629
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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