STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO6664SC5A7.14, probable transcriptional regulator, len: 301 aa; some similarity to many members of the araC family, e.g. MMSR_PSEAE MmsAB operon regulatory protein (307 aa), fasta scores; opt: 113 z-score: 251.4 E(): 9.2e-07, 25.4% identity in 303 aa overlap. Contains probable helix-turn-helix motif from aa 216-237 (Score 1252, +3.45 SD) and Pfam match to entry PF00165 HTH_2, Bacterial regulatory helix-turn-helix proteins, araC family, score 63.30, E-value 5.3e-15. (301 aa)    
Predicted Functional Partners:
SCO6663
SC5A7.13c, tktB, probable transketolase, len: 698 aa; highly similar to many e.g. TKT2_ECOLI transketolase 2 (EC 2.2.1.1) (667 aa), fasta scores; opt: 1191 z-score: 1912.7 E(): 0, 46.0% identity in 683 aa overlap. Contains PS00802 Transketolase signature 2 and Pfam match to entry PF00456 transketolase, Transketolase, score 1163.10, E-value 0; Belongs to the transketolase family.
       0.556
SCO6659
SC5A7.09c, pgi, glucose-6-phosphate isomerase, len: 550 aa; highly similar to many e.g. G6PI_ECOLI glucose-6-phosphate isomerase (EC 5.3.1.9) (549 aa), fasta sores; opt: 1878 z-score: 1900.7 E(): 0, 53.6% identity in 545 aa overlap. Contains PS00174 Phosphoglucose isomerase signature 2 and Pfam match to entry PF00342 PGI, Phosphoglucose isomerase, score 897.30, E-value 4.4e-266.
   
   0.507
SCO6662
Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily.
       0.503
SCO6661
Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone.
   
   0.471
SCO6658
SC5A7.08c, probable 6-phosphogluconate dehydrogenase, len: 293 aa; similar to many eukaryotic e.g. 6PGD_BACSU 6-phosphogluconate dehydrogenase, decarboxylating (468 aa), fasta sores; opt: 445 z-score: 616.2 E(): 4.4e-27, 36.6% identity in 287 aa overlap.also highly similar to S. coelicolor 6-phosphogluconate dehydrogenase (EMBL:L27063) TR:Q53917 (291 aa), fasta sores; opt: 1654 z-score: 2054.7 E(): 0, 83.4% identity in 289 aa overlap. Contains PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature and Pfam match to entry PF00393 6PGD, 6-phosphogluconate dehydrogen [...]
       0.469
SCO6657
SC5A7.07c, putative membrane protein, len: 527 aa; similar to two consecutive genes downstream of HISX_STRCO S. colelicolor histidinol dehydrogenase; TR:Q53931 and TR:Q53930, fasta scores; E(): 1.4e-07, 34.3% identity in 213 aa overlap and E(): 1.1e-06, 32.3% identity in 223 aa overlap. Contains possible hydrophobic membrane spanning region at C-terminal domain.
       0.458
SCO6464
Putative SIR2 family transcriptional regulator; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily.
 
  
 0.434
SCO6660
SC5A7.10c, unknown, len: 311 aa; similar to a hypothetical protein from M. tuberculosis TR:O06813 (EMBL:Z95844) MTCY493.08 (303 aa), fasta scores; opt: 847 z-score: 1016.2 E(): 0, 47.7% identity in 304 aa overlap. Also some similarity to OPCA_SYNP7 putative oxpp cycle protein OpCA (which may be involved in functional assembly of glucose 6-phosphate dehydrogenase) (444 aa), fasta scores; opt: 149 z-score: 218.9 E(): 5.9e-05, 32.4% identity in 142 aa overlap. Note that both of these proteins are downstream of glucose-6-phosphate dehydrogenase genes.
       0.430
SCO7307
SC5F8.17c, possible LysR-family transcriptional regulator, len: 300 aa. Similar to many other LysR-family proteins including: Corynebacterium glutamicum SW:LYSG_CORGL (EMBL:X96471) lysine export transcriptional regulatory protein, LysG (290 aa), fasta scores opt: 780 z-score: 918.3 E():0 44.5% identity in 290 aa overlap and Escherichia coli SW:ICIA_ECOLI (EMBL:M62865) chromosome initiation inhibitor, IciA (297 aa), fasta scores opt: 538 z-score: 635.6 E(): 6.2e-28 37.1% identity in 291 aa overlap. Contains a Prosite hit to PS00044 Bacterial regulatory proteins, lysR family signature an [...]
   
    0.400
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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