STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO6670SC5A7.20, probable glucosidase, len: 441 aa; similar to e.g. CELF_ECOLI 6-phospho-beta-glucosidase (450 aa), fasta scores; opt: 537 z-score: 628.7 E(): 8.8e-28, 31.8% identity in 456 aa overlap. (441 aa)    
Predicted Functional Partners:
SCO1390
SC1A8A.10, possible PTS system sugar phosphotransferase component IIA, len: 176a; similar to many e.g. TR:BAA82669 (EMBL:AB030569) putative phosphoenolpyruvate:carbohydrate phosphotransferase system family from Streptomyces griseus (149 aa) fasta scores; opt: 897, z-score: 951.7, E(): 0, 88.6% identity in 149 aa overlap and SW:P42015 (PTGA_BACST) PTS system, glucose-specific IIABC component from Bacillus stearothermophilus (324 aa) fasta scores; opt: 359, z-score: 386.4, E(): 4.3e-14, 40.6% identity in 143 aa overlap. Contains Pfam match to entry PF00358 PTS_EIIA_1, phosphoenolpyruvate [...]
 
  
 0.931
SCO2661
SC6D10.04, possible sugar hydrolase, len: 421 aa; similar to SW:CELF_ECOLI (EMBL:X52890) Escherichia coli 6-phospho-beta-glucosidase (EC 3.2.1.86) CelF, 450 aa; fasta scores: opt: 556 z-score: 624.0 E(): 2.4e-27; 36.0% identity in 431 aa overlap and to SW:AGAL_ECOLI (EMBL:X04894) Escherichia coli alpha-galactosidase (EC 3.2.1.22) (melibiase) MelA, 451 aa; fasta scores: opt: 300 z-score: 338.4 E(): 1.9e-11; 25.5% identity in 459 aa overlap.
  
  
 
0.919
SCO0063
SCJ4.44c, possible glucokinase, len: 311 aa; similar to many eg. SW:GLK_STRCO glucokinase from Streptomyces coelicolor (317 aa) fasta scores; opt: 175, z-score: 195.7, E(): 0.0015, (28.2% identity in 326 aa overlap). Contains Pfam match to entry PF00480 ROK, ROK family.
 
  
 0.915
SCO1059
SCG22.05, probable beta-glucosidase, len: 459 aa; similar to TR:Q59976 (EMBL:Z29625) Streptomyces sp. beta-glucosidase (EC 3.2.1.21) Bgl3, 479 aa; fasta scores: opt: 1627 z-score: 1895.8 E(): 0; 57.6% identity in 458 aa overlap. Contains Pfam match to entry PF00232 Glyco_hydro_1, Glycosyl hydrolase family 1 and match to Prosite entry PS00653 Glycosyl hydrolases family 1 N-terminal signature.
  
 
 0.911
SCO2531
Putative beta-glucosidase; SCC117.04, possible beta-glucosidase, len: 448 aa. Highly similar to many including: Microbispora bispora SW:BGLB_MICBI(EMBL:M97265) thermostable beta-glucosidase B (EC 3.2.1.21) (473 aa), fasta scores opt: 1059 z-score: 1221.1 E(): 0 48.7% identity in 454 aa overlap and Paenibacillus polymyxa (Bacillus polymyxa) SW:BGLA_PAEPO(EMBL:M60210) beta-glucosidase A (EC 3.2.1.21) (448 aa), fasta scores opt: 1014 z-score: 1169.7 E():0 40.4% identity in 455 aa overlap. Contains a Prosite hit to PS00653 Glycosyl hydrolases family 1 N-terminal signature and a Pfam match [...]
  
 
 0.911
SCO2798
2SCC13.06, probable cellobiose hydrolase, len: 479 aa; highly similar to TR:Q59976 (EMBL:Z29625) Streptomyces sp. beta-glucosidase (EC 3.2.1.21) (cellobiose) Bgl3, 479 aa; fasta scores: opt: 2214 z-score: 2511.6 E(): 0; 65.5% identity in 472 aa overlap. Contains Pfam match to entry PF00232 Glyco_hydro_1, Glycosyl hydrolase family 1 and matches to Prosite entries PS00653 Glycosyl hydrolases family 1 N-terminal signature and PS00572 Glycosyl hydrolases family 1 active site.
  
 
 0.911
SCO6604
SC1F2.01, probable beta-glucosidase, partial CDS, len >311 aa; similar to mnay e.g. BGLS_AGRSP beta-glucosidase (EC 3.2.1.21) (459 aa), fasta scores; opt: 784 z-score: 986.7 E(): 0, 42.5% identity in 315 aa overlap. Overlaps and extends SC8A6.25. Contains Pfam match to entry PF00232 glycosyl_hydro1, Glycosyl hydrolases family 1, score 350.20, E-value 2.2e-101; SC8A6.25, probable beta-glucosidase, partial CDS, le n >190 aa; highly similar to many e.g. BGLA_BACCI beta-glucosidase (EC 3.2.1.21) (449 aa), fasta scores; opt: 752 z-sc ore: 1084.7 E(): 0, 59.9% identity in 167 aa overlap. Con [...]
  
 
 0.911
SCO7558
SC5F1.12, probable beta-glucosidase, len: 479 aa; similar to TR:Q59976 (EMBL:Z29625) Streptomyces sp. beta-glucosidase (EC 3.2.1.21) Bgl3, 479 aa; fasta scores: opt: 2961 z-score: 3301.3 E(): 0; 88.9% identity in 479 aa overlap and to TR:CAC10107 (EMBL:AL442165) Streptomyces coelicolor putative cellobiose hydrolase 2SCC13.06, 479 aa; fasta scores: opt: 2255 z-score: 2227.1 E(): 0; 67.4% identity in 470 aa overlap. Contains Pfam match to entry PF00232 Glyco_hydro_1, Glycosyl hydrolase family 1 and match to Prosite entry PS00653 Glycosyl hydrolases family 1 N-terminal signature and PS005 [...]
  
 
 0.911
SCO2228
Alpha-glucosidase; SC10B7.23c, aglA, alpha-glucosidase, len: 577 aa; highly similar to TR:P72463 (EMBL:Y08304) Streptomyces limosus alpha-glucosidase AglA, 391 aa; fasta scores: opt: 1453 z-score: 1607.1 E(): 0; 72.0% identity in 347 aa overlap, to TR:AAD50603 (EMBL:AF096282) Thermus aquaticus alpha-glucosidase, 529 aa; fasta scores: opt: 925 z-score: 1022.3 E(): 0; 40.2% identity in 567 aa overlap and to SW:MAL2_DROVI (EMBL:AF006573) Drosophila virilis maltase 2 precursor (EC 3.2.1.20) Mal2, 524 aa; fasta scores: opt: 870 z-score: 961.6 E(): 0; 36.2% identity in 516 aa overlap. Contai [...]
     
 0.904
SCO3780
SCH63.27, probable sugar hydrolase, len: 556 aa; similar to SW:TREC_ECOLI (EMBL:U06195) Escherichia coli trehalose-6-phosphate hydrolase (EC 3.2.1.93) TreC, 551 aa; fasta scores: opt: 833 z-score: 927.7 E(): 0; 35.4% identity in 557 aa overlap and to TR:CAB90876 (EMBL:AL355753) Streptomyces coelicolor aglA, alpha-glucosidase SC10B7.23c, 577 aa; fasta scores: opt: 1146 z-score: 1084.7 E(): 0; 56.8% identity in 572 aa overlap. Contains Pfam match to entry PF00128 alpha-amylase, Alpha amylase.
     
 0.904
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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