STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO6764SC6A5.13, probable squalene-hopene cyclase, len: 680 aa; similar to many e.g. SW:SQHC_ALIAC squalene-hopene cyclase A key enzyme in triterpenoid metabolism in Bacillus acidocaldarius (630 aa) fasta scores; opt: 2153, z-score: 2386.3, E(): 0, (51.8% identity in 620 aa overlap). Contains two Pfam matches to entry PF00432 prenyltrans, Prenyltransferase and squalene oxidase repeats and a Prosite match to PS01074 Terpene synthases signature. (680 aa)    
Predicted Functional Partners:
SCO6766
Conserved hypothetical protein; SC6A5.15, unknown, len: 340 aa; similar to many of undefined function e.g. TR:P95416 (EMBL:D84475) NirJ, from a locus for heme D1 biosynthesis in Pseudomonas aeruginosa (387 aa) fasta scores; opt: 222, z-score: 264.2, E(): 2.1e-07, (24.2% identity in 207 aa overlap).
 
   
 0.989
SCO6765
SC6A5.14, possible lipoprotein, len: 213 aa; similar to SW:TYRT_STRLN proposed tyrosinase co-factor from the melanin biosynthesis in Streptomyces lincolnensis (140 aa) fasta scores; opt: 115, z-score: 142.8, E(): 1.2, (29.2% identity in 120 aa overlap). Contains Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
 
   
 0.983
SCO6760
SC6A5.09, probable phytoene synthase, len: 312aa; similar to many egs. SW:CRTB_MYCTU probable phytoene synthase from Mycobacterium tuberculosis (302 aa) fasta scores; opt: 791, z-score: 925.6, E(): 0, (48.3% identity in 286 aa overlap) and SW:PSY_ARATH phytoene synthase precusor from Arabidopsis thaliana (mouse ear cress) (423 aa) fasta scores; opt: 493, z-score: 577.3, E(): 7.4e-25, (34.4% identity in 282 aa overlap). Contains Pfam match to entry PF00494 SQS_PSY, Squalene and phytoene synthases, score 168.70, E-value 9.4e-47 and Prosite matches to PS01044 Squalene and phytoene synthas [...]
 
  
 0.964
SCO6759
SC6A5.08, probable phytoene synthase, len: 303aa; similar to many eg. TR:Q50892 (EMBL:Z21955) phytoene synthase from the light-induced carotenoid biosynthesis cluster of Myxococcus xanthus (336 aa) fasta scores; opt: 322, z-score: 379.7, E(): 7.5e-14, (31.8% identity in 274 aa overlap). Contains Pfam match to entry PF00494 SQS_PSY, Squalene and phytoene synthases, score 34.70, E-value 1.2e-08.
 
  
 0.958
SCO6762
SC6A5.11, possible phytoene dehydrogenase, len: 478aa; similar to many from eukaryotes eg. SW:CRTI_CAPAN phytoene dehydrogenase precursor from Capsicum annuum (bell pepper) (582 aa) fasta scores; opt: 276, z-score: 302.1, E(): 1.6e-09, (24.0% identity in 459 aa overlap). Also similar to prokaryotes eg. TR:P72449 (EMBL:X95596) proposed dehydrogenase from a cryptic carotenoid biosynthesis cluster in Streptomyces griseus (517 aa) fasta scores; opt: 206, z-score: 226.8, E(): 2.5e-05, (29.7% identity in 512 aa overlap).
 
   
 0.950
SCO6763
SC6A5.12, probable polyprenyl synthatase, len: 378aa; similar to many eg. SW:GGPP_MYCTU probable geranylgeranyl pyrophosphate synthatase from Mycobacterium tuberculosis (359 aa) fasta scores; opt: 1103, z-score: 1231.0, E(): 0, (49.3% identity in 355 aa overlap) and SW:IDSA_METTM short chain isoprenyl diphosphate synthase from Methanobacterium thermoautotrophicum (324 aa) fasta scores; opt: 547, z-score: 614.0, E(): 6.7e-27, (38.2% identity in 293 aa overlap). Contains Pfam match to entry PF00348 polyprenyl_synt, Polyprenyl synthetases, score 176.70, E-value 3.9e-49 and Prosite matches [...]
 
  
 0.941
SCO6769
SC6A5.18, probable aminotransferase, len: 461 aa; similar to many e.g. SW:ARGD_BACSU acetylornithine aminotransferase from Bacillus subtilis (385 aa) fasta scores; opt: 663, z-score: 757.6, E(): 0, (37.8% identity in 341 aa overlap). Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate and Prosite match to PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
 
   
 0.940
SCO6767
GcpE protein homolog, conserved hypothetical protein; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family.
     
 0.826
SCO6768
Probable transketolase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.
     
 0.824
SCO6770
SC6A5.19, probable DNA-binding protein, len: 204 aa; similar to several of undefined function eg. TR:O86784 (EMBL:AL031317) hypothetical protein from Streptomyces coelicolor (201 aa) fasta scores; opt: 297, z-score: 356.2, E(): 1.5e-12, (34.9% identity in 212 aa overlap). Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix.
       0.773
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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