STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SCO6818Putative phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (511 aa)    
Predicted Functional Partners:
SCO1946
SCC54.06c, pgk, phosphoglycerate kinase, len: 403 aa; member of a family of proteins highly conserved across prokaryotes and eukaryotes, e.g. SW:PGK_BACSU Pgk, phosphoglycerate kinase from Bacillus subtilis (394 aa) fasta scores; opt: 1263, z-score: 1322.3, E(): 0, (51.2% identity in 404 aa overlap) and SW:PGKH_SPIOL phosphoglycerate kinase from Spinacia oleracea (Spinach) (433 aa) fasta scores; opt: 1200, z-score: 1256.1, E(): 0, (49.9% identity in 407 aa overlap). Contains PS00111 Phosphoglycerate kinase signature and Pfam match to entry PF00162 PGK, Phosphoglycerate kinases, score 6 [...]
  
 
 0.988
SCO3096
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
  
 0.984
SCO7638
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
  
 0.984
SCO4209
Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.
    
 0.941
SCO2145
Putative glycerate kinase; SC6G10.18, unknown, len: 432aa; similar to many hypothetical proteins eg. SW:YXAA_BACSU hypothetical protein from Bacillus subtilis (382 aa) fasta scores; opt: 1005, z-score: 1049.9, E(): 0, (44.1% identity in 381 aa overlap). Note predicted C-terminal overlap with downstream CDS. Simialr also to SW:GRK_BACSU (EMBL:AB005554) Bacillus subtilis glycerate kinase (EC 2.7.1.31) GlxK or S14A, 382 aa; fasta scores: opt: 1005 Z-score:1015.2 E(): 6.5e-49; 44.094% identity in 381 aa overlap.
     
 0.912
SCO6466
Putative transferase; SC9C7.02, conserved hypothetical protein, len: 380 aa; similar to many e.g. SW:YXAA_BACSU hypothetical protein from Bacillus subtilis (382 aa) fasta scores; opt: 1045, z-score: 998.9, E(): 0, (46.3% identity in 374 aa overlap) and to SW:GRK_BACSU (EMBL:AB005554) Bacillus subtilis glycerate kinase (EC 2.7.1.31) GlxK, 382 aa; fasta scores: opt: 1045 Z-score: 991.1 E(): 1.4e-47; 46.257% identity in 374 aa overlap.
     
 0.912
SCO3478
SCE65.14c, probable dehydrogenase, len: 344 aa; similar to TR:O50095 (EMBL:AP000006) Pyrococcus horikoshii 307aa long hypothetical phosphoglycerate dehydrogenase PH1387, 307 aa; fasta scores: opt: 687 z-score: 777.1 E(): 0; 40.5% identity in 291 aa overlap and to SW:SERA_METTH (EMBL:AE000870;) Methanobacterium thermoautotrophicum D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) SerA, 525 aa; fasta scores: opt: 664 z-score: 748.1 E(): 0; 39.0% identity in 282 aa overlap. Contains Pfam match to entry PF00389 2-Hacid_DH, D-isomer specific 2-hydroxyacid dehydrogenases and match to Prosite [...]
    
 0.905
SCO5515
SC8D9.27, serA, D-3-phosphoglycerate dehydrogenase, len: 529 aa; member of a family including egs. SW:SERA_MYCLE putative SerA, D-3-phosphoglycerate dehydrogenase from Mycobacterium leprae (528 aa) fasta scores; opt: 1889, z-score: 2032.0, E(): 0, (56.9% identity in 524 aa overlap) and SW:SERA_BACSU SerA, D-3-phosphoglycerate dehydrogenase from Bacillus subtilis (525 aa) fasta scores; opt: 1176, z-score: 1266.5, E(): 0, (39.7% identity in 529 aa overlap). Contains PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature, PS00670 D-isomer specific 2-hydroxyacid dehyd [...]
    
 0.905
SCO6819
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
     
 0.888
SCO5852
SC9B10.19, agaY, possible tagatose-bisphosphate aldolase, len: 282 aa; similar to eg. AGAY_ECOLI P42908 tagatose-bisphosphate aldolase agaY (286 aa), fasta scores; opt: 585 z-score: 725.0 E(): 3.2e-33, 37.6% identity in 279 aa overlap.
  
 
 0.872
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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