node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SCO0547 | SCO3230 | gene:17758130 | gene:17760848 | SCF11.27c, possible acyltransferase, len: 333 aa; similar to TR:CAB52353 (EMBL:AL109747) Streptomyces coelicolor putative multi-domain beta keto-acyl synthase, 2082 aa; fasta scores: opt: 402 z-score: 416.4 E(): 8e-16; 32.5% identity in 329 aa overlap, and to TR:Q55226 (EMBL:L34880) Streptomyces sp. acyltransferase DauA, 338 aa; fasta scores: opt: 326 z-score: 349.0 E(): 4.5e-12; 33.4% identity in 326 aa overlap. Contains Pfam match to entry PF00698 acyl_transf, acyl transferase domain. | SCE63.03c, cdaPSI, CDA peptide synthetase I, len: 7463 aa; part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This CDS encodes a subunit of this enzyme and is suspected to be responsible for the incorperation of the first 6 amino acids into the antibiotic structure. This ORF overlaps the downstream (cdaPSII) ORF by one base indicating possible translational coupling. Contains eight separate Pfam matches to entry PF00668 [...] | 0.854 |
SCO0547 | SCO3231 | gene:17758130 | gene:17760849 | SCF11.27c, possible acyltransferase, len: 333 aa; similar to TR:CAB52353 (EMBL:AL109747) Streptomyces coelicolor putative multi-domain beta keto-acyl synthase, 2082 aa; fasta scores: opt: 402 z-score: 416.4 E(): 8e-16; 32.5% identity in 329 aa overlap, and to TR:Q55226 (EMBL:L34880) Streptomyces sp. acyltransferase DauA, 338 aa; fasta scores: opt: 326 z-score: 349.0 E(): 4.5e-12; 33.4% identity in 326 aa overlap. Contains Pfam match to entry PF00698 acyl_transf, acyl transferase domain. | SCE63.02c, cdaPS2, CDA peptide synthetase II, len: 3670 aa; part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This CDS encodes a subunit of this enzyme and is suspected to be responsible for the addition of 3 amino acids to the peptide antibiotic. This ORF overlaps the upstream (cdaPSI) and downstream (cdaPSIII) ORFs by one base indicating possible translational coupling of all three. Contains four separate Pfam matche [...] | 0.468 |
SCO0547 | SCO3232 | gene:17758130 | gene:17760850 | SCF11.27c, possible acyltransferase, len: 333 aa; similar to TR:CAB52353 (EMBL:AL109747) Streptomyces coelicolor putative multi-domain beta keto-acyl synthase, 2082 aa; fasta scores: opt: 402 z-score: 416.4 E(): 8e-16; 32.5% identity in 329 aa overlap, and to TR:Q55226 (EMBL:L34880) Streptomyces sp. acyltransferase DauA, 338 aa; fasta scores: opt: 326 z-score: 349.0 E(): 4.5e-12; 33.4% identity in 326 aa overlap. Contains Pfam match to entry PF00698 acyl_transf, acyl transferase domain. | SCE63.01, partial CDS, cdaPS3, CDA peptide synthetase III, len: >332 aa; Constitutes the N-terminus of cdaPS3, CDA peptide synthetase III, part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This partial CDS encodes the N-terminus of a subunit of this enzyme suspected to be responsible for the addition of 2 amino acids to the peptide antibiotic. This ORF overlaps the upstream (cdaPSII) by one base indicating possible tra [...] | 0.471 |
SCO0547 | SCO5892 | gene:17758130 | gene:17763552 | SCF11.27c, possible acyltransferase, len: 333 aa; similar to TR:CAB52353 (EMBL:AL109747) Streptomyces coelicolor putative multi-domain beta keto-acyl synthase, 2082 aa; fasta scores: opt: 402 z-score: 416.4 E(): 8e-16; 32.5% identity in 329 aa overlap, and to TR:Q55226 (EMBL:L34880) Streptomyces sp. acyltransferase DauA, 338 aa; fasta scores: opt: 326 z-score: 349.0 E(): 4.5e-12; 33.4% identity in 326 aa overlap. Contains Pfam match to entry PF00698 acyl_transf, acyl transferase domain. | SC3F7.12, redL, probable polyketide synthase, len: 2297 aa; contains 3 modules: N-terminus (start to approx. aa 700) similar to eg. N-terminus of TR:Q50857 (EMBL:U24657) saframycin mx1 synthetase B from Myxococcus xanthus (1770 aa) (fasta scores; E(): 0, 45.0% identity in 691 aa overlap), contains Pfam match to AMP-binding PF00501, AMP-binding enzymes, score 166.66; central module (approx aa 795 to 1800) similar to eg. TR:G2317861 (EMBL:U78289) Streptomyces fradiae tylactone synthase module 3 (1864 aa) (E(): 0, 39.9% identity in 1125 aa overlap), contains PS00606 Beta-ketoacyl synthase [...] | 0.757 |
SCO0547 | SCO6827 | gene:17758130 | gene:17764486 | SCF11.27c, possible acyltransferase, len: 333 aa; similar to TR:CAB52353 (EMBL:AL109747) Streptomyces coelicolor putative multi-domain beta keto-acyl synthase, 2082 aa; fasta scores: opt: 402 z-score: 416.4 E(): 8e-16; 32.5% identity in 329 aa overlap, and to TR:Q55226 (EMBL:L34880) Streptomyces sp. acyltransferase DauA, 338 aa; fasta scores: opt: 326 z-score: 349.0 E(): 4.5e-12; 33.4% identity in 326 aa overlap. Contains Pfam match to entry PF00698 acyl_transf, acyl transferase domain. | SC4A9.04c, polyketide synthase, len: 2358 aa. Highly similar to many including: Stigmatella aurantiaca TR:AAF19813(EMBL:AF188287) polyketide synthase, MtAE, found within the Myxothiazol biosynthetic gene cluster (1947 aa), fasta scores opt: 2671 z-score: 2436.5 E():0 35.8% identity in 1770 aa overlap and Mycobacterium tuberculosis SW:PPSA_MYCTU(EMBL:Z74697) phenolpthiocerol synthesis polyketide synthase gene, PpsA (1876 aa), fasta scores opt: 2221 z-score: 2025.5 E(): 0 33.6% identity in 1761 aa overlap. Contains Prosite hits to PS00606 Beta-ketoacyl synthases active site and 2xPS00012 [...] | 0.994 |
SCO0547 | SCO7682 | gene:17758130 | gene:17765342 | SCF11.27c, possible acyltransferase, len: 333 aa; similar to TR:CAB52353 (EMBL:AL109747) Streptomyces coelicolor putative multi-domain beta keto-acyl synthase, 2082 aa; fasta scores: opt: 402 z-score: 416.4 E(): 8e-16; 32.5% identity in 329 aa overlap, and to TR:Q55226 (EMBL:L34880) Streptomyces sp. acyltransferase DauA, 338 aa; fasta scores: opt: 326 z-score: 349.0 E(): 4.5e-12; 33.4% identity in 326 aa overlap. Contains Pfam match to entry PF00698 acyl_transf, acyl transferase domain. | SC4C2.17, probable non-ribosomal peptide synthase, len: 2229 aa; similar to TR:AAG02364 (EMBL:AF210249) Streptomyces verticillus peptide synthetase NRPS2-1 BlmIV, 2626 aa; fasta scores: opt: 2485 z-score: 2429.3 E(): 0; 37.9% identity in 2203 aa overlap, to SW:HMP2_YEREN (EMBL:L18881) Yersinia enterocolitica high-molecular-weight protein 2 Irp2, 2035 aa; fasta scores: opt: 2251 z-score: 2201.3 E(): 0; 33.3% identity in 2022 aa overlap to TR:CAA18919 (EMBL:AL023496) Streptomyces coelicolor probable peptide synthase SC1A6.21, 1407 aa; fasta scores: opt: 1764 z-score: 1430.4 E(): 0; 40.0% [...] | 0.506 |
SCO3230 | SCO0547 | gene:17760848 | gene:17758130 | SCE63.03c, cdaPSI, CDA peptide synthetase I, len: 7463 aa; part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This CDS encodes a subunit of this enzyme and is suspected to be responsible for the incorperation of the first 6 amino acids into the antibiotic structure. This ORF overlaps the downstream (cdaPSII) ORF by one base indicating possible translational coupling. Contains eight separate Pfam matches to entry PF00668 [...] | SCF11.27c, possible acyltransferase, len: 333 aa; similar to TR:CAB52353 (EMBL:AL109747) Streptomyces coelicolor putative multi-domain beta keto-acyl synthase, 2082 aa; fasta scores: opt: 402 z-score: 416.4 E(): 8e-16; 32.5% identity in 329 aa overlap, and to TR:Q55226 (EMBL:L34880) Streptomyces sp. acyltransferase DauA, 338 aa; fasta scores: opt: 326 z-score: 349.0 E(): 4.5e-12; 33.4% identity in 326 aa overlap. Contains Pfam match to entry PF00698 acyl_transf, acyl transferase domain. | 0.854 |
SCO3230 | SCO3231 | gene:17760848 | gene:17760849 | SCE63.03c, cdaPSI, CDA peptide synthetase I, len: 7463 aa; part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This CDS encodes a subunit of this enzyme and is suspected to be responsible for the incorperation of the first 6 amino acids into the antibiotic structure. This ORF overlaps the downstream (cdaPSII) ORF by one base indicating possible translational coupling. Contains eight separate Pfam matches to entry PF00668 [...] | SCE63.02c, cdaPS2, CDA peptide synthetase II, len: 3670 aa; part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This CDS encodes a subunit of this enzyme and is suspected to be responsible for the addition of 3 amino acids to the peptide antibiotic. This ORF overlaps the upstream (cdaPSI) and downstream (cdaPSIII) ORFs by one base indicating possible translational coupling of all three. Contains four separate Pfam matche [...] | 0.992 |
SCO3230 | SCO3232 | gene:17760848 | gene:17760850 | SCE63.03c, cdaPSI, CDA peptide synthetase I, len: 7463 aa; part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This CDS encodes a subunit of this enzyme and is suspected to be responsible for the incorperation of the first 6 amino acids into the antibiotic structure. This ORF overlaps the downstream (cdaPSII) ORF by one base indicating possible translational coupling. Contains eight separate Pfam matches to entry PF00668 [...] | SCE63.01, partial CDS, cdaPS3, CDA peptide synthetase III, len: >332 aa; Constitutes the N-terminus of cdaPS3, CDA peptide synthetase III, part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This partial CDS encodes the N-terminus of a subunit of this enzyme suspected to be responsible for the addition of 2 amino acids to the peptide antibiotic. This ORF overlaps the upstream (cdaPSII) by one base indicating possible tra [...] | 0.985 |
SCO3230 | SCO5892 | gene:17760848 | gene:17763552 | SCE63.03c, cdaPSI, CDA peptide synthetase I, len: 7463 aa; part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This CDS encodes a subunit of this enzyme and is suspected to be responsible for the incorperation of the first 6 amino acids into the antibiotic structure. This ORF overlaps the downstream (cdaPSII) ORF by one base indicating possible translational coupling. Contains eight separate Pfam matches to entry PF00668 [...] | SC3F7.12, redL, probable polyketide synthase, len: 2297 aa; contains 3 modules: N-terminus (start to approx. aa 700) similar to eg. N-terminus of TR:Q50857 (EMBL:U24657) saframycin mx1 synthetase B from Myxococcus xanthus (1770 aa) (fasta scores; E(): 0, 45.0% identity in 691 aa overlap), contains Pfam match to AMP-binding PF00501, AMP-binding enzymes, score 166.66; central module (approx aa 795 to 1800) similar to eg. TR:G2317861 (EMBL:U78289) Streptomyces fradiae tylactone synthase module 3 (1864 aa) (E(): 0, 39.9% identity in 1125 aa overlap), contains PS00606 Beta-ketoacyl synthase [...] | 0.989 |
SCO3230 | SCO6431 | gene:17760848 | gene:17764088 | SCE63.03c, cdaPSI, CDA peptide synthetase I, len: 7463 aa; part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This CDS encodes a subunit of this enzyme and is suspected to be responsible for the incorperation of the first 6 amino acids into the antibiotic structure. This ORF overlaps the downstream (cdaPSII) ORF by one base indicating possible translational coupling. Contains eight separate Pfam matches to entry PF00668 [...] | SC1A6.20, probable peptide synthase, len: 1171 aa; similar to many e.g. TR:Q44103 (EMBL:X97860) Amycolatopsis mediterranei aps gene for peptide synthetase (1324 aa), fasta scores; opt: 379 z-score: 1175.7 E(): 0, 32.3% identity in 993 aa overlap. Contains PS00455 Putative AMP-binding domain signature, PS00012 Phosphopantetheine attachment site and Pfam match to entry AMP-binding PF00501, AMP-binding enzymes, score 421.02. | 0.978 |
SCO3230 | SCO6432 | gene:17760848 | gene:17764089 | SCE63.03c, cdaPSI, CDA peptide synthetase I, len: 7463 aa; part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This CDS encodes a subunit of this enzyme and is suspected to be responsible for the incorperation of the first 6 amino acids into the antibiotic structure. This ORF overlaps the downstream (cdaPSII) ORF by one base indicating possible translational coupling. Contains eight separate Pfam matches to entry PF00668 [...] | SC1A6.21, probable peptide synthase, len: 1407 aa; similar to many e.g. TR:Q54959 (EMBL:X98690) Streptomyces pristinaespiralis Pristinamycin I synthase 2 (2591 aa), fasta scores; opt: 743 z-score: 754.8 E(): 0, 33.1% identity in1298 aa overlap. Contains PS00455 Putative AMP-binding domain signature, PS00012 Phosphopantetheine attachment site, PS00120 Lipases, serine active site and Pfam match to entry AMP-binding PF00501, AMP-binding enzymes, score 430.73. | 0.909 |
SCO3230 | SCO6560 | gene:17760848 | gene:17764217 | SCE63.03c, cdaPSI, CDA peptide synthetase I, len: 7463 aa; part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This CDS encodes a subunit of this enzyme and is suspected to be responsible for the incorperation of the first 6 amino acids into the antibiotic structure. This ORF overlaps the downstream (cdaPSII) ORF by one base indicating possible translational coupling. Contains eight separate Pfam matches to entry PF00668 [...] | SC4B5.10c, respiratory chain oxidoreductase, len: 646 aa; C-terminal region is similar to the N-terminal region of many proteins involved in electron transfer e.g. TR:O27592 (EMBL:AE000915) NADP-reducing hydrogenase, subunit C from Methanobacterium thermoautotrophicum (630 aa), fasta scores; opt: 121,4 z-score: 1170.7, E(): 0, (47.1% identity in 397 aa overlap). Contains PS00645 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. | 0.987 |
SCO3230 | SCO6827 | gene:17760848 | gene:17764486 | SCE63.03c, cdaPSI, CDA peptide synthetase I, len: 7463 aa; part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This CDS encodes a subunit of this enzyme and is suspected to be responsible for the incorperation of the first 6 amino acids into the antibiotic structure. This ORF overlaps the downstream (cdaPSII) ORF by one base indicating possible translational coupling. Contains eight separate Pfam matches to entry PF00668 [...] | SC4A9.04c, polyketide synthase, len: 2358 aa. Highly similar to many including: Stigmatella aurantiaca TR:AAF19813(EMBL:AF188287) polyketide synthase, MtAE, found within the Myxothiazol biosynthetic gene cluster (1947 aa), fasta scores opt: 2671 z-score: 2436.5 E():0 35.8% identity in 1770 aa overlap and Mycobacterium tuberculosis SW:PPSA_MYCTU(EMBL:Z74697) phenolpthiocerol synthesis polyketide synthase gene, PpsA (1876 aa), fasta scores opt: 2221 z-score: 2025.5 E(): 0 33.6% identity in 1761 aa overlap. Contains Prosite hits to PS00606 Beta-ketoacyl synthases active site and 2xPS00012 [...] | 0.991 |
SCO3230 | SCO7682 | gene:17760848 | gene:17765342 | SCE63.03c, cdaPSI, CDA peptide synthetase I, len: 7463 aa; part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This CDS encodes a subunit of this enzyme and is suspected to be responsible for the incorperation of the first 6 amino acids into the antibiotic structure. This ORF overlaps the downstream (cdaPSII) ORF by one base indicating possible translational coupling. Contains eight separate Pfam matches to entry PF00668 [...] | SC4C2.17, probable non-ribosomal peptide synthase, len: 2229 aa; similar to TR:AAG02364 (EMBL:AF210249) Streptomyces verticillus peptide synthetase NRPS2-1 BlmIV, 2626 aa; fasta scores: opt: 2485 z-score: 2429.3 E(): 0; 37.9% identity in 2203 aa overlap, to SW:HMP2_YEREN (EMBL:L18881) Yersinia enterocolitica high-molecular-weight protein 2 Irp2, 2035 aa; fasta scores: opt: 2251 z-score: 2201.3 E(): 0; 33.3% identity in 2022 aa overlap to TR:CAA18919 (EMBL:AL023496) Streptomyces coelicolor probable peptide synthase SC1A6.21, 1407 aa; fasta scores: opt: 1764 z-score: 1430.4 E(): 0; 40.0% [...] | 0.964 |
SCO3230 | SCO7683 | gene:17760848 | gene:17765343 | SCE63.03c, cdaPSI, CDA peptide synthetase I, len: 7463 aa; part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This CDS encodes a subunit of this enzyme and is suspected to be responsible for the incorperation of the first 6 amino acids into the antibiotic structure. This ORF overlaps the downstream (cdaPSII) ORF by one base indicating possible translational coupling. Contains eight separate Pfam matches to entry PF00668 [...] | SC4C2.18, probable non-ribosomal peptide synthase, len: 1842 aa; similar to C-terminal domain of TR:AAG02364 (EMBL:AF210249) Streptomyces verticillus peptide synthetase NRPS2-1 BlmIV, 2626 aa; fasta scores: opt: 2514 z-score: 2613.8 E(): 0; 40.7% identity in 1287 aa overlap, to TR:Q9RFM7 (EMBL:AF184622) Pseudomonas aeruginosa pyochelin synthetase PchF, 1809 aa; fasta scores: opt: 2279 z-score: 2370.9 E(): 0; 39.7% identity in 1887 aa overlap, to TR:CAA18919 (EMBL:AL023496) Streptomyces coelicolor probable peptide synthase SC1A6.21, 1407 aa; fasta scores: opt: 1826 z-score: 1476.6 E(): [...] | 0.905 |
SCO3231 | SCO0547 | gene:17760849 | gene:17758130 | SCE63.02c, cdaPS2, CDA peptide synthetase II, len: 3670 aa; part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This CDS encodes a subunit of this enzyme and is suspected to be responsible for the addition of 3 amino acids to the peptide antibiotic. This ORF overlaps the upstream (cdaPSI) and downstream (cdaPSIII) ORFs by one base indicating possible translational coupling of all three. Contains four separate Pfam matche [...] | SCF11.27c, possible acyltransferase, len: 333 aa; similar to TR:CAB52353 (EMBL:AL109747) Streptomyces coelicolor putative multi-domain beta keto-acyl synthase, 2082 aa; fasta scores: opt: 402 z-score: 416.4 E(): 8e-16; 32.5% identity in 329 aa overlap, and to TR:Q55226 (EMBL:L34880) Streptomyces sp. acyltransferase DauA, 338 aa; fasta scores: opt: 326 z-score: 349.0 E(): 4.5e-12; 33.4% identity in 326 aa overlap. Contains Pfam match to entry PF00698 acyl_transf, acyl transferase domain. | 0.468 |
SCO3231 | SCO3230 | gene:17760849 | gene:17760848 | SCE63.02c, cdaPS2, CDA peptide synthetase II, len: 3670 aa; part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This CDS encodes a subunit of this enzyme and is suspected to be responsible for the addition of 3 amino acids to the peptide antibiotic. This ORF overlaps the upstream (cdaPSI) and downstream (cdaPSIII) ORFs by one base indicating possible translational coupling of all three. Contains four separate Pfam matche [...] | SCE63.03c, cdaPSI, CDA peptide synthetase I, len: 7463 aa; part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This CDS encodes a subunit of this enzyme and is suspected to be responsible for the incorperation of the first 6 amino acids into the antibiotic structure. This ORF overlaps the downstream (cdaPSII) ORF by one base indicating possible translational coupling. Contains eight separate Pfam matches to entry PF00668 [...] | 0.992 |
SCO3231 | SCO3232 | gene:17760849 | gene:17760850 | SCE63.02c, cdaPS2, CDA peptide synthetase II, len: 3670 aa; part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This CDS encodes a subunit of this enzyme and is suspected to be responsible for the addition of 3 amino acids to the peptide antibiotic. This ORF overlaps the upstream (cdaPSI) and downstream (cdaPSIII) ORFs by one base indicating possible translational coupling of all three. Contains four separate Pfam matche [...] | SCE63.01, partial CDS, cdaPS3, CDA peptide synthetase III, len: >332 aa; Constitutes the N-terminus of cdaPS3, CDA peptide synthetase III, part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This partial CDS encodes the N-terminus of a subunit of this enzyme suspected to be responsible for the addition of 2 amino acids to the peptide antibiotic. This ORF overlaps the upstream (cdaPSII) by one base indicating possible tra [...] | 0.994 |
SCO3231 | SCO5892 | gene:17760849 | gene:17763552 | SCE63.02c, cdaPS2, CDA peptide synthetase II, len: 3670 aa; part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This CDS encodes a subunit of this enzyme and is suspected to be responsible for the addition of 3 amino acids to the peptide antibiotic. This ORF overlaps the upstream (cdaPSI) and downstream (cdaPSIII) ORFs by one base indicating possible translational coupling of all three. Contains four separate Pfam matche [...] | SC3F7.12, redL, probable polyketide synthase, len: 2297 aa; contains 3 modules: N-terminus (start to approx. aa 700) similar to eg. N-terminus of TR:Q50857 (EMBL:U24657) saframycin mx1 synthetase B from Myxococcus xanthus (1770 aa) (fasta scores; E(): 0, 45.0% identity in 691 aa overlap), contains Pfam match to AMP-binding PF00501, AMP-binding enzymes, score 166.66; central module (approx aa 795 to 1800) similar to eg. TR:G2317861 (EMBL:U78289) Streptomyces fradiae tylactone synthase module 3 (1864 aa) (E(): 0, 39.9% identity in 1125 aa overlap), contains PS00606 Beta-ketoacyl synthase [...] | 0.978 |