STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO7020SC1H10.09, amlB, secreted alpha-amylase (EC 3.2.1.1), len: 506 aa. Highly similar to Streptomyces lividans TR:P97179(EMBL:Z85949) alpha-amylase, AmlB (573 aa), fasta scores opt: 3422 z-score: 3742.9 E(): 0 98.6% identity in 506 aa overlap and Streptomyces violaceus SW:AMY_STRVL(EMBL:U22894) alpha-amylase precursor (EC 3.2.1.1), (569 aa), fasta scores opt: 2682 z-score: 2933.9 E(): 0 77.1% identity in 502 aa overlap. Contains a Pfam match to entry PF00128 alpha-amylase, Alpha amylase and a possible N-terminal signal sequence. (506 aa)    
Predicted Functional Partners:
SCO7338
SC4G10.17, glgX, possible glycogen debranching enzyme, len: 715 aa. Previously sequenced region: Streptomyces coelicolor TR:Q9X947(EMBL:AJ001206) (715 aa). Highly similar to Escherichia coli SW:GLGX_ECOLI(EMBL:J01616) glycogen operon protein, GlgX (EC 3.2.1.-) (657 aa), fasta scores opt: 1948 z-score: 2333.6 E():0 47.5% identity in 673 aa overlap and Streptomyces coelicolor TR:CAB76010(EMBL:AL157916) putative glycosyl hydrolase, GlgX2 or SC3D11.13c (782 aa), fasta scores opt: 2622 z-score: 3141.4 E(): 0 58.5% identity in 725 aa overlap. Contains a Pfam match to entry PF00128 alpha-amyl [...]
 
 
 0.934
SCO5441
SC6A11.17c, pep2A, hypothetical protein, len: 464 aa; previously sequenced as TR:O54204 (EMBL:AJ001205).
  
 0.933
SCO7333
Hypothetical protein; SC4G10.12c, pep2B, unknown, len: 453 aa. Previously sequenced Streptomyces coelicolor TR:O70013(EMBL:AJ001206) hypothetical protein, Pep2 (453 aa). Highly similar to Streptomyces coelicolor TR:CAB72417(EMBL:AL138978) hypothetical 50.3 kd protein, Pep2A or SC6A11.17c (464 aa), fasta scores opt: 1629 z-score: 1819.8 E(): 0 55.8% identity in 462 aa overlap.
  
 0.933
SCO5444
SC3D11.01, glgP, possible glycogen phosphorylase, len: >201aa; previously sequenced as TR:O70011 (EMBL:AJ001205). Also similar to TR:Q9YGA7 (EMBL:AF115479) maltodextrin phosphorylase from Thermococcus litoralis (831 aa) fasta scores; opt: 242, z-score: 283.2, E(): 2.3e-08, 30.9% identity in 194 aa overlap; SC6A11.20, glgP, possible glycogen phosphorylase (fragment), len: >705 aa; previously sequenced as TR:O70011 (EMBL:AJ001205). Also similar to TR:Q9YGA7 (EMBL:AF115479) maltodextrin phosphorylase from Thermococcus litoralis (831 aa) fasta scores; opt: 849, z-score: 972.3, E(): 0, 40.5 [...]
  
 0.931
SCO6082
SCBAC1A6.06c, glgX3, glycogen debranching enzyme, len: 702 aa; similar to SW:GLGX_ECOLI (EMBL:J01616) Escherichia coli glycogen operon protein GlgX or GlyX (EC 3.2.1.*), 657 aa; fasta scores: opt: 1883 z-score: 2219.2 E(): 0; 45.5% identity in 664 aa overlap. Contains Pfam match to entry PF00128 alpha-amylase, Alpha amylase; Belongs to the glycosyl hydrolase 13 family.
 
 
 0.931
SCO2228
Alpha-glucosidase; SC10B7.23c, aglA, alpha-glucosidase, len: 577 aa; highly similar to TR:P72463 (EMBL:Y08304) Streptomyces limosus alpha-glucosidase AglA, 391 aa; fasta scores: opt: 1453 z-score: 1607.1 E(): 0; 72.0% identity in 347 aa overlap, to TR:AAD50603 (EMBL:AF096282) Thermus aquaticus alpha-glucosidase, 529 aa; fasta scores: opt: 925 z-score: 1022.3 E(): 0; 40.2% identity in 567 aa overlap and to SW:MAL2_DROVI (EMBL:AF006573) Drosophila virilis maltase 2 precursor (EC 3.2.1.20) Mal2, 524 aa; fasta scores: opt: 870 z-score: 961.6 E(): 0; 36.2% identity in 516 aa overlap. Contai [...]
 
  
  0.930
SCO5456
SC3D11.13c, glgX2, possible glycosyl hydrolase (putative secreted protein), len: 782 aa; similar to many eg. TR:Q9X947 (EMBL:AJ001206) putative glycogen debranching enzyme from Streptomyces coelicolor (715 aa) fasta scores; opt: 2630, z-score: 2693.4, E(): 0, 58.5% identity in 725 aa overlap and SW:P15067 (GLGX_ECOLI) glycogen operon protein from Escherichia coli (657 aa) fasta scores; opt: 1608, z-score: 1647.7, E(): 0, 47.2% identity in 669 aa overlap. Contains Pfam match to entry PF00128 alpha-amylase, Alpha amylase. Contains possible N-terminal region signal peptide sequence.
 
 
 0.930
SCO3780
SCH63.27, probable sugar hydrolase, len: 556 aa; similar to SW:TREC_ECOLI (EMBL:U06195) Escherichia coli trehalose-6-phosphate hydrolase (EC 3.2.1.93) TreC, 551 aa; fasta scores: opt: 833 z-score: 927.7 E(): 0; 35.4% identity in 557 aa overlap and to TR:CAB90876 (EMBL:AL355753) Streptomyces coelicolor aglA, alpha-glucosidase SC10B7.23c, 577 aa; fasta scores: opt: 1146 z-score: 1084.7 E(): 0; 56.8% identity in 572 aa overlap. Contains Pfam match to entry PF00128 alpha-amylase, Alpha amylase.
 
  
  0.928
SCO5440
1,4-alpha-glucan branching enzyme; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
  
 
 0.928
SCO7332
1,4-alpha-glucan branching enzyme; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
  
 
 0.928
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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