STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO7119SC4B10.20, probable dehydrogenase, len: 312 aa; similar to SW:SERA_METJA (EMBL:U67544) Methanococcus jannaschii D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) SerA, 524 aa; fasta scores: opt: 407 z-score: 451.9 E(): 1e-17; 31.6% identity in 266 aa overlap and to TR:CAB37585 (EMBL:AL035569) Streptomyces coelicolor putative oxidoreductase SC8D9.21c, 313 aa; fasta scores: opt: 1071 z-score: 988.6 E(): 0; 56.0% identity in 307 aa overlap. Contains Pfam match to entry PF00389 2-Hacid_DH, D-isomer specific 2-hydroxyacid dehydrogenases and match to Prosite entry PS00671 D-isomer specific 2- [...] (312 aa)    
Predicted Functional Partners:
SCO4366
Putative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
  
 
 0.705
SCO7118
Hypothetical protein SC4B10.19c; SC4B10.19c, unknown, len: 254 aa.
       0.507
SCO3322
SCE68.20, putative membrane protein, len: 298 aa; unknown function, similar to TR:O33611 (EMBL:AB004855) Streptomyces cyaneus hypothetical protein (277 aa), fasta scores; opt: 463 z-score: 536.3 E(): 1.5e-22, 34.2% identity in 269 aa overlap. C-terminus similar to other hypothetical proteins e.g. SW:YV32_MYCTU (EMBL:Z77162) from Mycobacterium tuberculosis (373 aa) (57.8% identity in 256 aa overlap) and SCH5.21 (EMBL:AL035636) S.coelicolor hypothetical protein (268 aa) (36.3% identity in 267 aa overlap). Contains possible hydrophobic membrane spanning region at C-terminal domain.
  
 
 0.463
SCO2509
Undecaprenyl phosphate synthetase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
 
     0.444
SCO1657
Putative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
   
  
 0.439
SCO3858
Conserved hypothetical protein; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
 
     0.422
SCO7120
SC4B10.21, qcrB2, ubiquinol-cytochrome C reductase cytochrome B subunit, len: 539 aa; similar to SW:QCRB_STRCO (EMBL:AL049497) Streptomyces coelicolor ubiquinol-cytochrome C reductase cytochrome B subunit QcrB or SC6G10.21c, 545 aa; fasta scores: opt: 2311 z-score: 2220.7 E(): 0; 59.4% identity in 537 aa overlap and to SW:QCRB_STRLI (EMBL:AF107888) Streptomyces lividans ubiquinol-cytochrome C reductase cytochrome B subunit QcrB, 549 aa; fasta scores: opt: 2148 z-score: 2064.6 E(): 0; 56.3% identity in 542 aa overlap. Contains Pfam match to entry PF00033 cytochrome_b_N, Cytochrome b(N-t [...]
     
 0.411
SCO4293
SCD95A.26, probable threonine synthase, len: 428 aa; similar to TR:P73711 (EMBL:D90908) Synechocystis sp. threonine synthase ThrC, 433 aa; fasta scores: opt: 1467 z-score: 1612.7 E(): 0; 55.0% identity in 422 aa overlap. Contains Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependent enzyme.
  
  
 0.408
SCO5355
Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
  
  
 0.408
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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