node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SCO1657 | SCO4293 | gene:17759250 | gene:17761938 | Putative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | SCD95A.26, probable threonine synthase, len: 428 aa; similar to TR:P73711 (EMBL:D90908) Synechocystis sp. threonine synthase ThrC, 433 aa; fasta scores: opt: 1467 z-score: 1612.7 E(): 0; 55.0% identity in 422 aa overlap. Contains Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependent enzyme. | 0.568 |
SCO1657 | SCO4366 | gene:17759250 | gene:17762011 | Putative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Putative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.583 |
SCO1657 | SCO5355 | gene:17759250 | gene:17763007 | Putative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | 0.568 |
SCO1657 | SCO7119 | gene:17759250 | gene:17764779 | Putative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | SC4B10.20, probable dehydrogenase, len: 312 aa; similar to SW:SERA_METJA (EMBL:U67544) Methanococcus jannaschii D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) SerA, 524 aa; fasta scores: opt: 407 z-score: 451.9 E(): 1e-17; 31.6% identity in 266 aa overlap and to TR:CAB37585 (EMBL:AL035569) Streptomyces coelicolor putative oxidoreductase SC8D9.21c, 313 aa; fasta scores: opt: 1071 z-score: 988.6 E(): 0; 56.0% identity in 307 aa overlap. Contains Pfam match to entry PF00389 2-Hacid_DH, D-isomer specific 2-hydroxyacid dehydrogenases and match to Prosite entry PS00671 D-isomer specific 2- [...] | 0.439 |
SCO2509 | SCO7119 | gene:17760111 | gene:17764779 | Undecaprenyl phosphate synthetase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | SC4B10.20, probable dehydrogenase, len: 312 aa; similar to SW:SERA_METJA (EMBL:U67544) Methanococcus jannaschii D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) SerA, 524 aa; fasta scores: opt: 407 z-score: 451.9 E(): 1e-17; 31.6% identity in 266 aa overlap and to TR:CAB37585 (EMBL:AL035569) Streptomyces coelicolor putative oxidoreductase SC8D9.21c, 313 aa; fasta scores: opt: 1071 z-score: 988.6 E(): 0; 56.0% identity in 307 aa overlap. Contains Pfam match to entry PF00389 2-Hacid_DH, D-isomer specific 2-hydroxyacid dehydrogenases and match to Prosite entry PS00671 D-isomer specific 2- [...] | 0.444 |
SCO3322 | SCO4366 | gene:17760941 | gene:17762011 | SCE68.20, putative membrane protein, len: 298 aa; unknown function, similar to TR:O33611 (EMBL:AB004855) Streptomyces cyaneus hypothetical protein (277 aa), fasta scores; opt: 463 z-score: 536.3 E(): 1.5e-22, 34.2% identity in 269 aa overlap. C-terminus similar to other hypothetical proteins e.g. SW:YV32_MYCTU (EMBL:Z77162) from Mycobacterium tuberculosis (373 aa) (57.8% identity in 256 aa overlap) and SCH5.21 (EMBL:AL035636) S.coelicolor hypothetical protein (268 aa) (36.3% identity in 267 aa overlap). Contains possible hydrophobic membrane spanning region at C-terminal domain. | Putative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.692 |
SCO3322 | SCO7119 | gene:17760941 | gene:17764779 | SCE68.20, putative membrane protein, len: 298 aa; unknown function, similar to TR:O33611 (EMBL:AB004855) Streptomyces cyaneus hypothetical protein (277 aa), fasta scores; opt: 463 z-score: 536.3 E(): 1.5e-22, 34.2% identity in 269 aa overlap. C-terminus similar to other hypothetical proteins e.g. SW:YV32_MYCTU (EMBL:Z77162) from Mycobacterium tuberculosis (373 aa) (57.8% identity in 256 aa overlap) and SCH5.21 (EMBL:AL035636) S.coelicolor hypothetical protein (268 aa) (36.3% identity in 267 aa overlap). Contains possible hydrophobic membrane spanning region at C-terminal domain. | SC4B10.20, probable dehydrogenase, len: 312 aa; similar to SW:SERA_METJA (EMBL:U67544) Methanococcus jannaschii D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) SerA, 524 aa; fasta scores: opt: 407 z-score: 451.9 E(): 1e-17; 31.6% identity in 266 aa overlap and to TR:CAB37585 (EMBL:AL035569) Streptomyces coelicolor putative oxidoreductase SC8D9.21c, 313 aa; fasta scores: opt: 1071 z-score: 988.6 E(): 0; 56.0% identity in 307 aa overlap. Contains Pfam match to entry PF00389 2-Hacid_DH, D-isomer specific 2-hydroxyacid dehydrogenases and match to Prosite entry PS00671 D-isomer specific 2- [...] | 0.463 |
SCO3858 | SCO7119 | gene:17761483 | gene:17764779 | Conserved hypothetical protein; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | SC4B10.20, probable dehydrogenase, len: 312 aa; similar to SW:SERA_METJA (EMBL:U67544) Methanococcus jannaschii D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) SerA, 524 aa; fasta scores: opt: 407 z-score: 451.9 E(): 1e-17; 31.6% identity in 266 aa overlap and to TR:CAB37585 (EMBL:AL035569) Streptomyces coelicolor putative oxidoreductase SC8D9.21c, 313 aa; fasta scores: opt: 1071 z-score: 988.6 E(): 0; 56.0% identity in 307 aa overlap. Contains Pfam match to entry PF00389 2-Hacid_DH, D-isomer specific 2-hydroxyacid dehydrogenases and match to Prosite entry PS00671 D-isomer specific 2- [...] | 0.422 |
SCO4293 | SCO1657 | gene:17761938 | gene:17759250 | SCD95A.26, probable threonine synthase, len: 428 aa; similar to TR:P73711 (EMBL:D90908) Synechocystis sp. threonine synthase ThrC, 433 aa; fasta scores: opt: 1467 z-score: 1612.7 E(): 0; 55.0% identity in 422 aa overlap. Contains Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependent enzyme. | Putative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.568 |
SCO4293 | SCO4366 | gene:17761938 | gene:17762011 | SCD95A.26, probable threonine synthase, len: 428 aa; similar to TR:P73711 (EMBL:D90908) Synechocystis sp. threonine synthase ThrC, 433 aa; fasta scores: opt: 1467 z-score: 1612.7 E(): 0; 55.0% identity in 422 aa overlap. Contains Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependent enzyme. | Putative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.940 |
SCO4293 | SCO5355 | gene:17761938 | gene:17763007 | SCD95A.26, probable threonine synthase, len: 428 aa; similar to TR:P73711 (EMBL:D90908) Synechocystis sp. threonine synthase ThrC, 433 aa; fasta scores: opt: 1467 z-score: 1612.7 E(): 0; 55.0% identity in 422 aa overlap. Contains Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependent enzyme. | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | 0.921 |
SCO4293 | SCO7119 | gene:17761938 | gene:17764779 | SCD95A.26, probable threonine synthase, len: 428 aa; similar to TR:P73711 (EMBL:D90908) Synechocystis sp. threonine synthase ThrC, 433 aa; fasta scores: opt: 1467 z-score: 1612.7 E(): 0; 55.0% identity in 422 aa overlap. Contains Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependent enzyme. | SC4B10.20, probable dehydrogenase, len: 312 aa; similar to SW:SERA_METJA (EMBL:U67544) Methanococcus jannaschii D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) SerA, 524 aa; fasta scores: opt: 407 z-score: 451.9 E(): 1e-17; 31.6% identity in 266 aa overlap and to TR:CAB37585 (EMBL:AL035569) Streptomyces coelicolor putative oxidoreductase SC8D9.21c, 313 aa; fasta scores: opt: 1071 z-score: 988.6 E(): 0; 56.0% identity in 307 aa overlap. Contains Pfam match to entry PF00389 2-Hacid_DH, D-isomer specific 2-hydroxyacid dehydrogenases and match to Prosite entry PS00671 D-isomer specific 2- [...] | 0.408 |
SCO4366 | SCO1657 | gene:17762011 | gene:17759250 | Putative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | Putative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.583 |
SCO4366 | SCO3322 | gene:17762011 | gene:17760941 | Putative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | SCE68.20, putative membrane protein, len: 298 aa; unknown function, similar to TR:O33611 (EMBL:AB004855) Streptomyces cyaneus hypothetical protein (277 aa), fasta scores; opt: 463 z-score: 536.3 E(): 1.5e-22, 34.2% identity in 269 aa overlap. C-terminus similar to other hypothetical proteins e.g. SW:YV32_MYCTU (EMBL:Z77162) from Mycobacterium tuberculosis (373 aa) (57.8% identity in 256 aa overlap) and SCH5.21 (EMBL:AL035636) S.coelicolor hypothetical protein (268 aa) (36.3% identity in 267 aa overlap). Contains possible hydrophobic membrane spanning region at C-terminal domain. | 0.692 |
SCO4366 | SCO4293 | gene:17762011 | gene:17761938 | Putative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | SCD95A.26, probable threonine synthase, len: 428 aa; similar to TR:P73711 (EMBL:D90908) Synechocystis sp. threonine synthase ThrC, 433 aa; fasta scores: opt: 1467 z-score: 1612.7 E(): 0; 55.0% identity in 422 aa overlap. Contains Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependent enzyme. | 0.940 |
SCO4366 | SCO5355 | gene:17762011 | gene:17763007 | Putative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | 0.940 |
SCO4366 | SCO7119 | gene:17762011 | gene:17764779 | Putative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | SC4B10.20, probable dehydrogenase, len: 312 aa; similar to SW:SERA_METJA (EMBL:U67544) Methanococcus jannaschii D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) SerA, 524 aa; fasta scores: opt: 407 z-score: 451.9 E(): 1e-17; 31.6% identity in 266 aa overlap and to TR:CAB37585 (EMBL:AL035569) Streptomyces coelicolor putative oxidoreductase SC8D9.21c, 313 aa; fasta scores: opt: 1071 z-score: 988.6 E(): 0; 56.0% identity in 307 aa overlap. Contains Pfam match to entry PF00389 2-Hacid_DH, D-isomer specific 2-hydroxyacid dehydrogenases and match to Prosite entry PS00671 D-isomer specific 2- [...] | 0.705 |
SCO5355 | SCO1657 | gene:17763007 | gene:17759250 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | Putative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.568 |
SCO5355 | SCO4293 | gene:17763007 | gene:17761938 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | SCD95A.26, probable threonine synthase, len: 428 aa; similar to TR:P73711 (EMBL:D90908) Synechocystis sp. threonine synthase ThrC, 433 aa; fasta scores: opt: 1467 z-score: 1612.7 E(): 0; 55.0% identity in 422 aa overlap. Contains Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependent enzyme. | 0.921 |
SCO5355 | SCO4366 | gene:17763007 | gene:17762011 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | Putative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.940 |