STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO7165SC9A4.27c, probable sugar-binding integral membrane transport protein, len: 319 aa; similar to TR:Q9RJV6 (EMBL:AL117387) Streptomyces coelicolor putative binding-protein-dependent transport protein SCF41.13, 280 aa; fasta scores: opt: 1039 z-score: 1201.7 E(): 0; 57.2% identity in 264 aa overlap and to SW:MSMG_STRMU (EMBL:M77351) Streptococcus mutans multiple sugar-binding transport system permease protein MsmG, 277 aa; fasta scores: opt: 512 z-score: 596.7 E(): 9.1e-26; 32.4% identity in 275 aa overlap. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transpo [...] (303 aa)    
Predicted Functional Partners:
SCO7166
SC9A4.28c, probable sugar-transporter integral membrane protein, len: 310 aa; similar to TR:Q9RJV7 (EMBL:AL117387) Streptomyces coelicolor putative binding protein dependent transport protein SCF41.12, 303 aa; fasta scores: opt: 913 z-score: 1073.6 E(): 0; 46.9% identity in 309 aa overlap. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component and match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Also contains possible hydrophobic membrane spanning regions.
 
 0.987
SCO4240
ABC transporter ATP-binding protein; Part of the ABC transporter complexes DasABC-MsiK and NgcEFG- MsiK involved in N,N'-diacetylchitobiose ((GlcNAc)2) uptake. Responsible for energy coupling to the transport system.
 
 0.963
SCO1707
SCI30A.28c, probable ABC sugar transporter, ATP-binding subunit, len: 445aa; similar to many eg. TR:AAD24578 (EMBL:AF126010) trehalose/maltose transport ATP-hydrolysing subunit from hyperthermophilic archaeon Thermococcus litoralis (372 aa) fasta scores; opt: 975, z-score: 1068.2, E(): 0, (50.1% identity in 335 aa overlap). Contains Pfam match to entry PF00005 ABC_tran, ABC transporter and Prosite matches to PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop).
 
 0.957
SCO0291
SCF85.19, possible binding protein dependent transport protein, len: 300 aa. Similar to many including: Streptomyces lividans TR:Q9ZI17 (EMBL; AF043654) BxlF (317 aa), fasta scores opt: 873 z-score: 1049.2 E(): 0 44.0% identity in 298 aa overlap and Streptomyces coelicolor TR:CAB41203 (EMBL; AL049661)putative binding protein dependent transport protein SCE134.05C (327 aa), fasta scores opt: 551 z-score: 664.3 E(): 1.2e-29 32.7% identity in 294 aa overlap. Contains a Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component and a PS0040 [...]
 
 0.924
SCO0292
SC5G9.01, probable sugar ABC-transporter integral membrane protein, partial CDS, len: >148 aa; similar to e.g. TR:O51925 (EMBL:AF012836), malG, Thermococcus litoralis inner membrane protein from trehalose/maltose ABC-transporter system (278 aa), fasta scores; opt: 296 z-score: 384.7 E(): 4.6e-14, 32.2% identity in 146 aa overlap. Also similar to many putative ABC-transporter components e.g. SW:YOR2_CALSR (EMBL:L18965) Caldicellulosiruptor sp. (strain Rt8B.4) putative membrane bound sugar transport protein ORF2 (275 aa) (43.0% identity in 142 aa overlap). Contains hydrophobic, possible [...]
  
  
 
0.922
SCO7167
SC9A4.29c, probable secreted sugar-binding protein, len: 425 aa; similar to TR:Q9RJV8 (EMBL:AL117387) Streptomyces coelicolor putative solute-binding protein SCF41.11, 422 aa; fasta scores: opt: 946 z-score: 1081.0 E(): 0; 40.1% identity in 419 aa overlap and to SW:MSME_STRMU (EMBL:M77351) Streptococcus mutans multiple sugar-binding protein precursor MsmE, 420 aa; fasta scores: opt: 233 z-score: 268.9 E(): 1.6e-07; 25.3% identity in 297 aa overlap. Contains 2x Pfam matches to entry PF01547 SBP_bacterial_1, Bacterial extracellular solute-binding protein and correctly situated match to P [...]
 
 
 0.913
SCO0354
SCF41.13, possible binding-protein-dependent transport protein, len: 280 aa, Similar to many e.g. Streptomyces coelicolor TR:O50501 (EMBL; AL009199) probable transmembrane transport protein SC7b7.04 (302 aa), fasta scores opt: 584 z-score: 670.3 E(): 5.5e-30 36.1% identity in 274 aa overlap. Contains multiple membrane spanning hydrophobic domains, a PS00402 Binding-protein-dependent transport systems inner membrane comp sign and a Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component.
  
  
 
0.903
SCO0290
SCF85.18, probable solute-binding protein, len: 436 aa. Similar to many including: Streptomyces lividans TR:Q9Z492 (EMBL; AF043654) BxlE precursor (434 aa), fasta scores opt: 946 z-score: 1058.6 E(): 0 33.7% identity in 427 aa overlap and Streptococcus mutans SW:MSME_STRMU (EMBL; M77351) multiple sugar-binding protein precursor MsmE (420 aa), fasta scores opt: 258 z-score: 291.6 E(): 6.9e-09 24.2% identity in 351 aa overlap. Contains a Pfam match to entry PF01547 SBP_bacterial_1, PS00013 Prokaryotic membrane lipoprotein lipid attachment site and a PS00017 ATP/GTP-binding site motif A ( [...]
  
 0.863
SCO0454
SCF51A.32, probable binding-protein dependent transport protein, len: 313 aa. Similar to many including: Streptomyces coelicolor TR:CAB41203 (EMBL; AL049661) putative protein SCE134.05C (327 aa), fasta scores opt: 479 z-score: 546.7 E(): 4.3e-23 31.4% identity in 315 aa overlap. Contains a Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component and a Prosite hit to PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Contains multiple possible membrane spanning hydrophobic domains.
 
 
 0.853
SCO0271
SCF1.13, possible binding-protein-dependent transport protein, len: 317aa; similar to many predicted membrane transporters eg. TR:CAB41203 (EMBL:AL049661) putative binding-protein-dependent transport protein from Streptomyces coelicolor (327 aa) fasta scores; opt: 624, z-score: 720.7, E(): 8.8e-33, (35.9% identity in 320 aa overlap). Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, Prosite match to PS00402 Binding-protein-dependent transport systems inner membrane comp sign. and possible membrane spanning hydrophobic [...]
 
 
 0.850
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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