STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO7220Conserved hypothetical protein SC2H12.19c; SC2H12.19c, unknown, len: 667 aa. Similar to many proteins of undefined function from Streptomyces coelicolor e.g. TR:Q9RJC6(EMBL:AL133171) SCF81.26 (835 aa), opt: 1057 z-score: 1135.5 E():0 38.6% identity in 643 aa overlap. (667 aa)    
Predicted Functional Partners:
SCO0717
SCF42.27, possible integral membrane protein, len: 375 aa. Similar to several other membrane proteins from Streptomyces coelicolor e.g. TR:CAB56388(EMBL:AL118515) SCD17.11 (454 aa), fasta scores opt: 569 z-score: 648.9 E(): 9.3e-29 36.4% identity in 360 aa overlap. Contains multiple possible membrane spanning hydrophobic domains.
  
     0.771
SCO4107
SCD17.11, possible integral membrane protein, len: 454 aa. Similar to many e.g. Streptomyces coelicolor TR:O69922 (EMBL; AL023861) putative integral membrane protein SC3C8.09 (367 aa), fasta scores opt: 687 z-score: 689.9 E(): 4.5e-31 37.2% identity in 368 aa overlap. Contains possible membrane spanning hydrophobic domains. Contains probable coiled coil between residues 270..307 (probability 0.85).
  
     0.764
SCO6321
SCIF3.23, possible integral membrane protein, len: 362 aa; highly similar to TR:Q9KZX9 (EMBL:AL353815) Streptomyces coelicolor putative integral membrane protein SCD6.25, 362 aa; fasta scores: opt: 1695 z-score: 1862.4 E(): 0; 73.8% identity in 362 aa overlap. Contains possible hydrophobic membrane spanning regions.
  
     0.758
SCO4447
SCD6.25, possible integral membrane protein, len: 362 aa; similar to TR:CAB56388 (EMBL:AL118515) Streptomyces coelicolor putative integral membrane protein SCD17.11, 454 aa; fasta scores: opt: 715 z-score: 760.4 E(): 0; 41.6% identity in 368 aa overlap. Contains possible hydrophobic membrane spanning regions.
  
     0.753
SCO5933
SC7H1.03c, possible membrane protein, len: 391 aa; C-terminal part similar to TR:Q9L0E7 (EMBL:AL161803) Streptomyces coelicolor hypothetical protein SCD31.20, 181 aa; fasta scores: opt: 592 Z-score: 665.9 E(): 1.8e-29; 53.514% identity in 185 aa overlap. Contains possible hydrophobic membrane spanning regions. Contains PS00213 Lipocalin signature, though this may be spurious.
  
     0.749
SCO3785
SCH63.32c, possible integral membrane protein, len: 409 aa; similar to TR:CAB95784 (EMBL:AL359949) Streptomyces coelicolor putative integral membrane protein 2SCG61.09, 387 aa; fasta scores: opt: 464 z-score: 500.7 E(): 2.3e-20; 32.5% identity in 379 aa overlap. Contains possible hydrophobic membrane spanning regions.
  
     0.732
SCO3549
Putative anti-sigma factor antagonist; Positive regulator of sigma-B activity. Non-phosphorylated RsbV binds to RsbW, preventing its association with sigma-B. When phosphorylated, releases RsbW, which is then free to complex with and inactivate sigma-B (By similarity).
  
   0.728
SCO7748
SC8D11.39, hypothetical protein, len: 567 aa; similar to TR:CAC14487 (EMBL:AL446003) Streptomyces coelicolor putative DNA-binding protein SC5E9.07, 531 aa; fasta scores: opt: 473 z-score: 523.3 E(): 1.3e-21; 30.3% identity in 433 aa overlap. Contains match to Prosite entry PS00237 G-protein coupled receptors signature and 4x degenerate repeat: HAVVP.
  
     0.725
SCO7380
Conserved hypothetical protein; SC10G8.07c, unknown, len: 437 aa. Similar in parts to several proteins of undefined function e.g. Streptomyces coelicolor TR:Q9ZBJ0 (EMBL:AL035161) conserved hypothetical protein, SC9C7.20 (860 aa), fasta scores opt: 271 z-score: 309.7 E(): 7.7e-10 30.3% identity in 274 aa overlap.
  
     0.713
SCP1.41c
Hypothetical protein; SCP1.41c, unknown, len: 411aa; weakly similar to many eg. TR:Q9L195 (EMBL:AL158057) hypothetical protein from Streptomyces coelicolor (437 aa) fasta scores; opt: 476, z-score: 570.6, E(): 2.6e-24, 32.7% identity in 327 aa overlap.
  
     0.664
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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