STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
SCO7326Conserved hypothetical protein; SC4G10.05c, unknown, len: 824 aa. Similar to several Streptomyces coelicolor proteins of undefined function e.g. TR:CAB61192(EMBL:AL132973) SCF91.35 (884 aa), fasta scores opt: 385 z-score: 407.5 E(): 3.1e-15 26.1% identity in 885 aa overlap. (824 aa)    
Predicted Functional Partners:
SCO7327
SC4G10.06c, possible two-component system sensory histidine kinase, len: 1331 aa. Highly similar in parts to many including: Pseudomonas syringae (pv. syringae) SW:LEMA_PSESY(EMBL:M80477) sensor protein, LemA (EC 2.7.3.-), (907 aa), fasta scores opt: 641 z-score: 627.6 E(): 1.7e-27 31.2% identity in 872 aa overlap and Streptomyces coelicolor TR:O86808(EMBL:AL031031) putative sensory histidine kinase, SC7C7.03 (1829 aa), fasta scores opt: 2600 z-score: 2540.8 E():0 59.1% identity in 1346 aa overlap. Contains Pfam matches to entries PF00072 response_reg, Response regulator receiver domai [...]
 
  
 0.906
SCO7325
SC4G10.04c, anti-sigma factor antagonist, len: 130 aa. Similar to many including: Bacillus licheniformis SW:SP21_BACLI (EMBL:M25260) anti-sigma F factor antagonist (stage II sporulation protein AA) (117 aa), fasta scores opt: 187 z-score: 252.1 E(): 1.4e-06 28.4% identity in 109 aa overlap and Streptomyces coelicolor SW:RSBV_STRCO (EMBL:AF134889) anti-sigma factor antagonist, BldG (113 aa), fasta scores opt: 196 z-score: 263.7 E(): 3.2e-07 26.5% identity in 102 aa overlap. Contains a Pfam match to entry PF01740 SpoIIAA, SpoIIAA family.
 
   0.705
SCO2026
SC3A3.04c, gltB, probable glutamate synthase large subunit, len: 1514 aa; similar to bacterial glutamate synthases e.g. TR:Q51583 (EMBL:D85230), gltB, Plectonema boryanum large subunit of NADH-dependent glutamate synthase (1530 aa), fasta scores; opt: 5662 z-score: 6172.3 E(): 0, 56.4% identity in 1518 aa overlap. Also similar to part of eukaryotic glutamate synthases e.g. SW:GLSN_MEDSA (EMBL:L01660) Medicago sativa (Alfalfa) Glutamate synthase [NADH] precursor (2194 aa) (49.9% identity in 1577 aa overlap).
  
  
 0.605
SCO0599
SCF55.23, probable regulator of sig8, 309 aa; identical to previously sequenced TR:CAB55832 (EMBL:AJ249580) Streptomyces coelicolor putative regulator of sig8, 309 aa and to TR:Q9ZBT2 (EMBL:AL034446) Streptomyces coelicolor putative regulatory protein SC1A9.20, 153 aa; fasta scores: opt: 167 z-score: 197.6 E(): 0.0012; 40.4% identity in 114 aa overlap.
 
   0.574
SCO7328
Putative regulatory protein; SC4G10.07c, possible regulatory protein, len: 144 aa. Highly similar to Streptomyces fradiae TR:Q9Z9I5 (EMBL:AB024056) beta-lactamase regulator protein (139 aa), fasta scores opt: 530 z-score: 661.7 E(): 2.2e-29 61.5% identity in 122 aa overlap and Streptomyces coelicolor TR:Q9X7S3 (EMBL:AL049863) putative regulator protein, SC5H1.15C (151 aa), fasta scores opt: 178 z-score: 231.0 E(): 2.1e-05 30.8% identity in 130 aa overlap.
  
   0.567
SCO0725
Hypothetical protein 3SC5B7.03; 3SC5B7.03, unknown, len: 125 aa.
       0.560
SCO5747
SC7C7.02c, possible regulatory protein, len: 916 aa; N-terminus is similar to S. coloicolor TR:Q53897 (EMBL:X60316) AbaA ORFA (192 aa), fasta scores; opt: 248 z-score: 257.6 E(): 4.1e-07, 34.2% identity in 187 aa overlapC-terminus is similar to several RsbU homologs e.g. Bacillus licheniformis TR:O50229 (EMBL:AF034567) putative sigma B regulator similar to B. subtilis RsbU phosphatase (335 aa), fasta scores; opt: 232 z-score: 196.5 E(): 0.001, 26.3% identity in 240 aa overlap.
 
 
0.557
SCO7324
SC4G10.03c, possible regulatory protein, len: 299 aa. Similar to Bacillus subtilis SW:RSBR_BACSU(EMBL:L35574) positive regulator of sigma-B activity, RsbR (274 aa), fasta scores opt: 401 z-score: 450.7 E(): 1.2e-17 27.6% identity in 279 aa overlap.
  
   0.552
SCO5748
SC7C7.03, probable sensory histidine kinase, len: 1829 aa; N-terminus has 11 92aa repeats. Highly similar to putative osmosensing histidine kinases from yeasts (with only five repeats) e.g. Neurospora crassa TR:Q01318 (EMBL:U53189) osmotic-1 locus putative histidine kinase (1298 aa), fasta scores; opt: 2011 z-score: 1764.6 E(): 0, 38.3% identity in 1281 aa overlap. Also similar to BARA_ECOLI sensor protein BarA (918 aa) (with only one copy of the repeat), fasta scores; opt: 378 z-score: 755.8, E(): 0, 28.9% identity in 619 aa overlap. Extreme N-terminus has similarity to the phosphoryl [...]
 
  
 0.548
SCO7323
SC4G10.02c, anti-sigma factor antagonist, len: 143 aa. Highly similar to many anti-anti sigma factors e.g. Bacillus subtilis SW:RSBS_BACSU (EMBL:L35574) anti-sigma factor antagonist, RsbS (121 aa), fasta scores opt: 341 z-score: 417.5 E(): 8.5e-16 43.4% identity in 113 aa overlap. Contains a Pfam match to entry PF01740 SpoIIAA, SpoIIAA family.
  
   0.537
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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