STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO7353Conserved hypothetical protein SC9H11.07; SC9H11.07, unknown, len: 155 aa. Highly similar to many bacterioferritin comigratory proteins e.g. Mycobacterium tuberculosis TR:O53911(EMBL:AL02200) putative bacterioferritin comigratory protein, BcpB (154 aa), fasta scores opt: 618 z-score: 761.9 E():0 63.8% identity in 149 aa overlap. Contains a Pfam match to entry PF00578 AhpC-TSA, AhpC/TSA family. (155 aa)    
Predicted Functional Partners:
SCO7352
Putative membrane protein; SC9H11.06, possible membrane protein, len: 126 aa. Similar to several proteins of undefined function from Deinococcus radiodurans e.g. TR:AAF11579(EMBL:AE002039) hypothetical 13.2 kd protein (120 aa), fasta scores opt: 304 z-score: 370.4 E(): 3.6e-13 48.2% identity in 112 aa overlap. Contains multiple possible membrane spanning hydrophobic domains.
       0.875
SCO7351
SC9H11.05, possible AraC-family transcriptional regulator, len: 289 aa. Similar to several including: Streptomyces coelicolor TR:O69819(EMBL:AL023496) transcriptional regulator, SC1A6.14 (256 aa), fasta scores opt: 397 z-score: 464.2 E(): 2.2e-18 33.5% identity in 254 aa overlap and Escherichia coli SW:YEAM_ECOLI(EMBL:AE000274) hypothetical transcriptional regulator (273 aa), fasta scores opt: 438 z-score: 510.8 E(): 5.4e-21 33.2% identity in 232 aa overlap. Contains a Pfam match to entry PF00165 HTH_AraC, Bacterial regulatory helix-turn-helix proteins, araC family with the putative he [...]
       0.833
SCO7354
Conserved hypothetical protein SC9H11.08; SC9H11.08, unknown, len: 802 aa. Similar to many proteins of undefined function e.g. Streptomyces coelicolor TR:CAB61537(EMBL:AL133171) hypothetical 89.7 kd protein, SCF81.26 (835 aa), fasta scores opt: 2446 z-score: 2641.1 E(): 0 53.0% identity in 800 aa overlap. Contains Pfam matches to 2xentry PF00989 PAS, PAS domain.
  
    0.740
SCO7350
SC9H11.04c, possible membrane efflux protein, len: 398 aa. Similar to many membrane efflux proteins including: Streptomyces lividans SW:CMLR_STRLI(EMBL:X59968) chloramphenicol resistance protein, CmlR (392 aa), fasta scores opt: 227 z-score: 239.8 E(): 6.8e-06 27.7% identity in 411 aa overlap and Escherichia coli SW:FSR_ECOLI(EMBL:D73370) fosmidomycin resistance protein, FsR (406 aa), fasta scores opt: 506 z-score: 524.2 E(): 9.8e-22 28.4% identity in 373 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Note that the C-terminal 37 aa of this protein are hig [...]
       0.727
SCO5250
2SC7G11.12, gtr, polyprenyl synthetase, len: 386 aa; previously sequenced as TR:Q9RGW1 (EMBL:AF104994) Streptomyces coelicolor A3(2) geranyl transferase Gtr, 386 aa. Contains Pfam match to entry PF00348 polyprenyl_synt, Polyprenyl synthetases and match to Prosite entry PS00723 Polyprenyl synthetases signature 1; Belongs to the FPP/GGPP synthase family.
     
 0.654
SCO2806
2SCC13.14c, possible mutase, len: 198 aa; similar to TR:O05852 (EMBL:Z95120) Mycobacterium tuberculosis hypothetical 21.9 kDa protein MTCY07D11.12c, 203 aa; fasta scores: opt: 487 z-score: 602.4 E(): 4.7e-26; 42.3% identity in 194 aa overlap. Contains Pfam match to entry PF00300 PGAM, Phosphoglycerate mutase family.
  
  
 0.647
SCO0487
SCF34.06, possible MarR-family transcriptional regulator, len: 168 aa; shows weak similarity to TR:Q53002 (EMBL:U51475), MucS, Rhizobium meliloti exopolysaccharide synthesis regulatory protein (190 aa), fasta scores; opt: 126 z-score: 160.1 E(): 0.15, 24.8% identity in 145 aa overlap and to hypothetical transcriptional regulators. Contains Pfam match to entry PF01047 MarR, MarR family.
       0.560
SCO2113
Putative bacterioferritin; Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.
      
 0.532
SCO0999
Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.
      
 0.529
SCO6768
Probable transketolase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.
     
 0.514
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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