STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO7530Putative regulatory protein; SC8G12.06c, possible regulatory protein, len: 360 aa. The N-terminus of this protein is similar to many regulatory proteins e.g. Deinococcus radiodurans TR:AAF11989(EMBL:AE002074) transcriptional regulator, MerR family (280 aa), fasta scores opt: 324 z-score: 367.6 E(): 5.1e-13 37.3% identity in 244 aa overlap. The C-terminus of this protein is similar to many hypothetical proteins and putative phosphatases e.g. Mycobacterium leprae TR:Q50188(EMBL:Z70722) putative phosphoprotein phosphatase (509 aa), fasta scores opt: 709 z-score: 790.9 E(): 0 54.6% identit [...] (360 aa)    
Predicted Functional Partners:
SCO2110
SC6E10.04, pkaF, probable eukaryotic-type serine/threonine protein kinase, len: 667 aa; previously sequenced as TR:Q9ZNB3 (EMBL:AB019394) S.coelicolor eukaryotic-type protein kinase (629 aa) and identical to that sequence, but with a different putative start codon. Similar to many e.g. SW:PKN2_MYXXA (EMBL:M94857), Pkn2, Myxococcus xanthus serine/threonine protein kinase involved in regulation of beta-lactamase secretion (830 aa), fasta scores; opt: 564 z-score: 531.4 E(): 2.8e-22, 35.5% identity in 366 aa overlap. Similar to many hypothetical protein serine/threonine protein kinases fr [...]
 
 
 0.986
SCO3848
SCH69.18, possible serine/threonine protein kinase, len: 673 aa; similar to many e.g. TR:P71584 (EMBL:Z80233) putative serine/threonine protein kinase from Mycobacterium tuberculosis (626 aa) fasta scores; opt: 1185, z-score: 1028.0, E(): 0, (42.0% identity in 646 aa overlap) and TR:P95308 (EMBL:X99618) serine/threonine protein kinase from Mycobacterium tuberculosis (662 aa) fasta scores; opt: 598, z-score: 522.8, E(): 8.6e-22, (33.9% identity in 345 aa overlap). Also similar to SCGD3.21c from Streptomyces coelicolor (522 aa) fasta scores; opt: 1104, z-score: 1039.5, E(): 0, (50.0% ide [...]
 
 
 0.986
SCO2554
DnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...]
  
 
 0.889
SCO3669
Molecular chaperone; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK [...]
  
 
 0.889
SCO1994
SC7H2.08, possible integral membrane protein, len: 118aa; contains possible membrane spanning hydrophobic region.
  
 
 0.885
SCO3252
SCE39.02c, repSA, replication initiator protein, len: 466 aa; highly similar to TR:E1288125 (EMBL:AJ005260) RepSA, replication initiator protein from the integrated conjugative plasmid pSAM2 of Streptomyces ambofaciens (459 aa) fasta scores; opt: 2822, z-score: 3195.3, E(): 0, (89.5% identity in 455 aa overlap) and TR:E1355655 (EMBL:AL034355) putative plasmid replication initiator protein from Streptomyces coelicolor (452 aa) fasta scores; opt: 732, z-score: 831.1, E(): 0, (45.8% identity in 459 aa overlap).
  
 
 0.885
SCO3936
SCD78.03, possible plasmid replication initiator protein within putative integrated plasmid, len: 452 aa; similar to REPS_STRAM (EMBL:Z19594) replication initiator protein from Streptomyces ambofaciens plasmid pSAM2 (459 aa), fasta scores; opt: 712 z-score: 983.7 E(): 0, (43.7% identity in 467 aa overlap). Note that there is no possible initiation codon upstream of the start of homology (or close downstream). The CDS given here has an arbitrary start.
  
 
 0.885
SCO3995
SCBAC25E3.32, partial possible replication initiator protein, len: 175 aa: similar to C-terminal region of many eg. SW:P36891 (REPS_STRAM) RepSA replication initiator protein from Streptomyces ambofaciens plasmid pSAM2 (459 aa) fasta scores; opt: 956, Z-score: 1170.4, 83.626% identity (83.626% ungapped) in 171 aa overlap. Gene may have been disrupted by translocation a event.
  
 
 0.885
SCO4166
SCD66.03, possible integral membrane protein, len: 97 aa. Contains possible hydrophobic membrane spanning regions.
  
 
 0.885
SCO5347
SCBAC5H2.16, repSA2, replication initiation protein, len: 454 aa; highly similar to plasmid borne SW:REPS_STRAM (EMBL:Z19594) Streptomyces ambofaciens replication initiation protein repSA, 459 aa; fasta scores: opt: 2806 z-score: 3256.0 E(): 0; 90.8% identity in 446 aa overlap and to TR:Q9X8C5 (EMBL:AL049573) Streptomyces coelicolor replication initiation protein repSA, 466 aa; fasta scores: opt: 2759 z-score: 3201.4 E(): 0; 88.1% identity in 453 aa overlap.
  
 
 0.885
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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