STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO7596SC7H9.08c, probable integral membrane transport protein, len: 523 aa; similar to SW:SGLT_VIBPA (EMBL:D78137) Vibrio parahaemolyticus sodium/glucose co-transporter (Na(+)/glucose symporter) SglT, 543 aa; fasta scores: opt: 445 z-score: 513.1 E(): 4.8e-21; 24.4% identity in 471 aa overlap. Contains Pfam match to entry PF00474 SSF, Sodium:solute symporter family. Also contains possible hydrophobic membrane spanning regions; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (523 aa)    
Predicted Functional Partners:
SCO7597
SC7H9.09c, hypothetical protein, len: 332 aa; similar to TR:Q9EX11 (EMBL:AL445503) Streptomyces coelicolor hypothetical 33.0 kDa protein 2SCG38.08, 332 aa; fasta scores: opt: 619 z-score: 588.5 E(): 3e-25; 45.3% identity in 329 aa overlap. High content in alanine amino acid residues.
 
     0.816
SCO5519
Conserved hypothetical protein; SC8D9.31, unknown, len: 308aa; similar to proteins of undefined function eg. TR:O50444 (EMBL:AL010186) from Mycobacterium tuberculosis (329 aa) fasta scores; opt: 984, z-score: 1121.1, E(): 0, (50.0% identity in 312 aa overlap).
  
  
 0.790
SCO7595
Conserved hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family.
 
     0.783
SCO1514
Adenine phosphoribosiltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
   
  
 0.631
SCO7598
Hypothetical protein SC7H9.10; SC7H9.10, unknown, len: 38 aa. Doubtful CDS, low content in G+C (63.15%).
       0.568
SCO0441
Conserved hypothetical protein SCF51A.19; Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
  
    0.538
SCO2831
SCE20.05, probable amino acid ABC transporter protein, ATP-binding component, len: 261 aa. Highly similar to many ATP-binding transport protein including: Bacillus stearothermophilus SW:GLNQ_BACST(EMBL:M61017) glutamine transport ATP-binding protein GLNQ (242 aa), fasta scores opt: 758 z-score: 851.7 E():0 47.5% identity in 242 aa overlap and Thermotoga maritima TR:Q9WZ60(EMBL:AE001734) amino acid ABC transporter, ATP-binding protein (242 aa), fasta scores opt: 829 z-score: 930.4 E(): 0 54.5% identity in 242 aa overlap. Also similar to several other Streptomyces coelicolor transport pr [...]
  
  
 0.492
SCO5258
2SC7G11.20c, atrC, ATP-binding protein, len: 253 aa; previously sequenced as TR:Q9RGW6 (EMBL:AF104994) Streptomyces coelicolor A3(2) ATP-binding protein AtrC, 239 aa. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature.
  
  
 0.492
SCO5777
SC4H8.16c, gluA, probable glutamate uptake system ATP-binding protein, len: 258 aa; highly similar to many amino-acid uptake ATP-binding proteins eg. GLUA_CORGL P48243 glutamate transport atp-binding protein from Corynebacterium gluamicum (242 aa), fasta scores; opt: 1152 z-score: 1564.5 E(): 0, 71.5% identity in 242 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature.
  
  
 0.492
SCO7599
SC7H9.11, probable transcriptional regulator, len: 311 aa; similar to SW:HEXR_ECOLI (EMBL:AE000279) Escherichia coli Hex regulon repressor HexR, 289 aa; fasta scores: opt: 428 z-score: 486.6 E(): 1.4e-19; 31.9% identity in 285 aa overlap. Contains Pfam match to entry PF01418 HTH_6, Helix-turn-helix domain, rpiR family and PF01380 SIS, SIS domain. Also contains possible helix-turn-helix motif at residues 54..75 (+3.19 SD).
       0.482
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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