STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO7660Voltage-gated potassium channel; Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel. (160 aa)    
Predicted Functional Partners:
SCO1472
SCL6.29c, conserved hypothetical Sun-family protein, len: 475 aa; similar to SW:SUN_BACSU (EMBL:Y13937) Bacillus subtilis sun protein, 447 aa; fasta scores: opt: 637 z-score: 711.7 E(): 3.2e-32; 32.0% identity in 472 aa overlap. Contains Pfam match to entry PF01029 NusB, NusB family and to entry PF01189 Nol1_Nop2_Sun, NOL1/NOP2/sun family and match to Prosite entry PS01153 NOL1/NOP2/sun family signature; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
  
   0.680
SCO7661
SC10F4.34, possible secreted protein, len: 212 aa; similar to TR:Q9XBC6 (EMBL:AL078635) Amycolatopsis orientalis hypothetical 22.9 kDa protein CZA382.25, 205 aa; fasta scores: opt: 324 z-score: 399.0 E(): 1.1e-14; 35.8% identity in 201 aa overlap. Contains possible N-terminal region signal peptide sequence.
       0.648
SCO5201
2SC3B6.25, moaE-like protein, len: 152 aa; similar to SW:MOAE_ECOLI (EMBL:X70420) Escherichia coli molybdopterin [mpt] converting factor, subunit 2 MoaE, 149 aa; fasta scores: opt: 255 z-score: 317.2 E(): 3.3e-10; 33.3% identity in 129 aa overlap.
   
    0.603
SCO3927
SCQ11.10c, possible membrane protein, len: 513 aa; unknown function, probable CDS with Pro/Arg-rich N-terminus and 4x degenerate GGGHGA repeats from aa 58-81. Contains hydrophobic, possible membrane-spanning regions.
  
   
 0.567
SCO2070
SC4A10.03, possible membrane protein, len: 382 aa; unknown function, shows weak similarity to parts of many hypothetical proteins e.g. SW:YB43_METJA (EMBL:U67556) Methanococcus jannaschii hypothetical protein (361 aa), fasta scores; opt: 222 z-score: 255.3 E(): 6.7e-07, 24.8% identity in 306 aa overlap. Contains hydrophobic, possible membrane-spanning regions. Contains Pfam match to entry PF00924 UPF0003, Uncharacterized protein family UPF0003.
     
 0.544
SCO2656
SC8E4A.26, possible membrane protein, len: 408 aa; similar to various hypothetical proteins, e.g. TR:Q9XA89 (EMBL:AL096837) Streptomyces coelicolor hypothetical 36.1 kD protein SCF43A.26c, 333 aa; fasta scores: opt: 661 z-score: 668.4 E(): 8.1e-30; 42.3% identity in 317 aa overlap. Contains Pfam match to entry PF00924 UPF0003, Uncharacterized protein family UPF0003 and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop). Contains also possible hydrophobic membrane spanning regions.
     
 0.544
SCO2712
SCC61A.33, possible membrane protein, len: 239aa; weakly similar to TR:Q9X4U6 (EMBL:AF118389) from cps locus of Streptococcus suis serotype 2 (229 aa) fasta scores; opt: 161, z-score: 172.0, E(): 0.04, 28.4% identity in 176 aa overlap. Contains possible membrane-spanning hydrophobic regions.
      
 0.537
SCO4045
2SCD60.11c, possible integral membrane protein, len: 226 aa; similar to TR:O06141 (EMBL:Z95554) Mycobacterium tuberculosis hypothetical 20.4 kDa protein MTCY01B2.16c, 195 aa; fasta scores: opt: 628 z-score: 680.7 E(): 2.4e-30; 50.8% identity in 191 aa overlap. Contains possible hydrophobic membrane spanning regions.
  
  
 0.533
SCO1785
SCI51.25c, probable iron-siderophore uptake system ATP-binding component, len: 301 aa; similar to many ATP-binding components from binding-protein-dependent iron uptake systems using a range of siderophores e.g. SW:FEPC_ECOLI (EMBL:X57471), fepC, Escherichia coli ferric enterobactin transport ATP-binding protein (271 aa), fasta scores; opt: 1101 z-score: 1184.4 E(): 0, 61.5% identity in 260 aa overlap. Similar to other binding-protein-dependent permease subunits e.g. SC9B1.09 (EMBL:AL049727) S.coelicolor putative ABC transporter ATP-binding subunit (386 aa) (37.7% identity in 228 aa ov [...]
      
 0.530
SCO3837
SCH69.07c, putative membrane protein, len: 436 aa. Contains possible hydrophobic membrane spanning regions.
      
 0.517
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
Server load: low (28%) [HD]