STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
SCO7700Putative cyclase; Catalyzes the cyclization of 2-methylgeranyl diphosphate (2- MeGPP) to 2-methylisoborneol (2-MIB), which likely involves the intermediacy of 2-methyllinalyl diphosphate. Is also able to catalyze the cyclization of geranyl diphosphate (GPP), albeit with much lower efficiency, leading to the formation of a complex mixture of cyclic monoterpenes, consisting of alpha-pinene (6%), beta-pinene (23%), limonene (32%), gamma-terpinene (29%), and delta-terpinene (10%). Belongs to the terpene synthase family. 2-methylisoborneol synthase subfamily. (440 aa)    
Predicted Functional Partners:
SCO7701
Putative methyltransferase; Catalyzes the SAM-dependent methylation of geranyl diphosphate (GPP) to yield (E)-2-methylgeranyl diphosphate (2-MeGPP).
 
   
 0.996
SCO6073
Putative cyclase; Tow-domain protein where the N-terminal domain catalyzes the cyclization of farnesyl diphosphate (FPP) to a 85:15 mixture of the sesquiterpene alcohol germacradienol and the sesquiterpene hydrocarbon germacrene D. The C-terminal domain partially converts the germacradienol formed into geosmin, the characteristic odoriferous ('earthy aroma') constituent of Streptomyces species.
  
   
 0.888
SCO7699
SC1A4.07, possible nucleotide-binding protein, len: 471 aa; highly similar to TR:Q54255 (EMBL:L76204) Streptomyces griseus sporulation-specific protein p3, 470 aa; fasta scores: opt: 2382 z-score: 2757.2 E(): 0; 75.8% identity in 472 aa overlap and to TR:CAC05970 (EMBL:AL391763) Streptomyces coelicolor putative nucleotide binding protein 2SC7G11.11, 468 aa; fasta scores: opt: 1972 z-score: 2283.0 E(): 0; 63.5% identity in 466 aa overlap. Contains Pfam match to entry PF00027 cNMP_binding, Cyclic nucleotide-binding domain.
 
   
 0.842
SCO4701
30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family.
      
 0.841
SCO6750
Putative IPP isomerase; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
     
 0.772
SCO7674
SC4C2.09, possible secreted metal-binding protein, len: 132 aa; similar to SW:AMCY_METEX (EMBL:M57963) Methylobacterium extorquens amicyanin-alpha precursor MauC, 119 aa; fasta scores: opt: 165 z-score: 185.2 E(): 0.0088; 29.8% identity in 121 aa overlap. Contains Pfam match to entry PF00127 copper-bind, Copper binding proteins, plastocyanin/azurin family and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and match to PS00017 ATP/GTP-binding site motif A (P-loop). Also contains possible N-terminal region signal peptide sequence.
  
   
 0.711
SCO5222
Putative lyase; Catalyzes the cyclization of farnesyl diphosphate (FPP) to the sesquiterpene epi-isozizaene.
      
 0.695
SCO6442
SC9B5.09, probable alcohol dehydrogenase, len: 367aa; similar to many eg. SW:XYLB_PSEPU aryl-alcohol dehydrogenase from Pseudomonas putida (366 aa) fasta scores; opt: 928, z-score: 888.5, E(): 0, (42.6% identity in 366 aa overlap). Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases.
      
 0.689
SCO6782
SC6A5.31c, probable zinc-binding alcohol dehydrogenase, len: 363aa; similar to many eg. TR:Q59096 (EMBL:U61983) benzyl alcohol dehydrogenase from Acinetobacter calcoaceticus (371 aa) fasta scores; opt: 948, z-score: 937.8, E(): 0, (42.8% identity in 360 aa overlap). Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases and Prosite match to PS00059 Zinc-containing alcohol dehydrogenases signature.
      
 0.689
SCO5822
SC5B8.12, gyrB2, probable DNA gyrase subunit B, len: 707 aa; highly similar to many e.g. GYRB_STAAU P20832 staph ylococcus aureus. dna gyrase subunit B (EC 5.99.1.3) (643 a a), fasta scores; opt: 954 z-score: 2020.9 E(): 0, 45.2% id entity in 683 aa overlap. Contains PS00177 DNA topoisomeras e II signature and Pfam match to entry DNA_topoisoII PF0020 4, DNA topoisomerase II, score 609.86.
     
 0.682
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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