STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
SCO7701Putative methyltransferase; Catalyzes the SAM-dependent methylation of geranyl diphosphate (GPP) to yield (E)-2-methylgeranyl diphosphate (2-MeGPP). (292 aa)    
Predicted Functional Partners:
SCO7700
Putative cyclase; Catalyzes the cyclization of 2-methylgeranyl diphosphate (2- MeGPP) to 2-methylisoborneol (2-MIB), which likely involves the intermediacy of 2-methyllinalyl diphosphate. Is also able to catalyze the cyclization of geranyl diphosphate (GPP), albeit with much lower efficiency, leading to the formation of a complex mixture of cyclic monoterpenes, consisting of alpha-pinene (6%), beta-pinene (23%), limonene (32%), gamma-terpinene (29%), and delta-terpinene (10%). Belongs to the terpene synthase family. 2-methylisoborneol synthase subfamily.
 
   
 0.996
SCO7699
SC1A4.07, possible nucleotide-binding protein, len: 471 aa; highly similar to TR:Q54255 (EMBL:L76204) Streptomyces griseus sporulation-specific protein p3, 470 aa; fasta scores: opt: 2382 z-score: 2757.2 E(): 0; 75.8% identity in 472 aa overlap and to TR:CAC05970 (EMBL:AL391763) Streptomyces coelicolor putative nucleotide binding protein 2SC7G11.11, 468 aa; fasta scores: opt: 1972 z-score: 2283.0 E(): 0; 63.5% identity in 466 aa overlap. Contains Pfam match to entry PF00027 cNMP_binding, Cyclic nucleotide-binding domain.
 
   
 0.817
SCO6073
Putative cyclase; Tow-domain protein where the N-terminal domain catalyzes the cyclization of farnesyl diphosphate (FPP) to a 85:15 mixture of the sesquiterpene alcohol germacradienol and the sesquiterpene hydrocarbon germacrene D. The C-terminal domain partially converts the germacradienol formed into geosmin, the characteristic odoriferous ('earthy aroma') constituent of Streptomyces species.
      
 0.795
SCO3262
Hypothetical protein; SCE39.12, unknown, len: 249aa; limited similarity to others of unknown function some of which are associated with bacteriophage eg. SW:VE31_LAMBD protein EA31 from bacteriophage lambda (296 aa) fasta scores; opt: 133, z-score: 164.9, E(): 0.071, (35.3% identity in 85 aa overlap). Contains TTA codon, possible target for bldA regulation.
  
     0.725
SCO7674
SC4C2.09, possible secreted metal-binding protein, len: 132 aa; similar to SW:AMCY_METEX (EMBL:M57963) Methylobacterium extorquens amicyanin-alpha precursor MauC, 119 aa; fasta scores: opt: 165 z-score: 185.2 E(): 0.0088; 29.8% identity in 121 aa overlap. Contains Pfam match to entry PF00127 copper-bind, Copper binding proteins, plastocyanin/azurin family and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and match to PS00017 ATP/GTP-binding site motif A (P-loop). Also contains possible N-terminal region signal peptide sequence.
  
   
 0.716
SCO0373
SCF41.32c, possible secreted protein, len: 199 aa. Contains a possible N-terminal signal sequence.
 
    0.687
SCO5222
Putative lyase; Catalyzes the cyclization of farnesyl diphosphate (FPP) to the sesquiterpene epi-isozizaene.
      
 0.668
SCO2678
SC6D10.21, hypothetical protein, len: 171 aa; similar to TR:CAB55735 (EMBL:AL117387) Streptomyces coelicolor putative secreted protein SCF41.32c, fasta scores: opt: 399 z-score: 488.3 E(): 8.7e-20; 45.6% identity in 169 aa overlap.
 
    0.652
SCO3261
SCE39.11, possible ATP-binding protein, len: 431 aa; limited similarity to others of unknown function eg. TR:Q47527 (EMBL:Z12832) hypothetical ATP-binding protein from Escherichia coli (492 aa) fasta scores; opt: 239, z-score: 271.8, E(): 7.9e-08, (32.0% identity in 153 aa overlap). Contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop).
  
     0.638
SCO6025
Hypothetical protein; SC1C3.13, unknown, len: 655 aa; C-terminus is similar to upstream genes TR:O69849 (EMBL:AL023702) SC1C3.07 (opt: 399 Z-score: 441.0 E(): 6.2e-17; 31.751% identity in 337 aa overlap) and TR:O69848 (EMBL:AL023702) SC1C3.06 (opt: 428 Z-score: 473.3 E(): 9.9e-19; 32.022% identity in 356 aa overlap).
 
     0.617
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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