STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO7704SCBAC12C8.05, possible TetR-family transcriptional regulator, len: 235 aa: similar to many from Streptomyces coelicolor e.g. TR:Q53901 (EMBL:M64683) ORF1-4 (ActII) (259 aa) fasta scores; opt: 310, Z-score: 362.1, 32.889% identity (35.071% ungapped) in 225 aa overlap. Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family and Pfam match to entry PF02909 tetR_C, Tetracyclin repressor, C-terminal all-alpha domain. (235 aa)    
Predicted Functional Partners:
SCO7705
SCBAC12C8.06, possible oxidoreductase, len: 396aa: similar to many eg. SW:Q01911 (TETX_BACFR) tetracycline resistance oxidoreductase from Bacteroides fragilis (388 aa) fasta scores; opt: 612, Z-score: 673.8, 31.818% identity (33.427% ungapped) in 374 aa overlap and TR:Q9F3M8 (EMBL:AL450350) putative oxidoreductase SC10F4.32c from Streptomyces coelicolor (373 aa) fasta scores; opt: 1391, Z-score: 1524.2, 59.116% identity (60.795% ungapped) in 362 aa overlap. Contains Pfam match to entry PF01360 Monooxygenase, Monooxygenase.
 
     0.748
SCO0993
2SCG2.06, conserved hypothetical protein, len: 412 aa; similar to SW:Y4RH_RHISN (EMBL:AE000094) Rhizobium sp. hypothetical 52.5 kDa protein Y4rH, 478 aa; fasta scores: opt: 348 z-score: 384.2 E(): 7.1e-14; 26.3% identity in 400 aa overlap.
  
     0.636
SCO7702
SCBAC12C8.03, possible GntR-family transcriptional regulator, len: 236aa: similar to many eg. TR:Q9S276 (EMBL:AL096844) putative GntR-family transcriptional regulator SCI28.07 from Streptomyces coelicolor (230 aa) fasta scores; opt: 532, Z-score: 608.3, 46.262% identity (46.698% ungapped) in 214 aa overlap and SW:P33233 (LLDR_ECOLI) putative lactate dehydrogenase operon regulator from Escherichia coli (258 aa) fasta scores; opt: 263, Z-score: 305.7, 29.204% identity (31.884% ungapped) in 226 aa overlap. Partially previously sequenced as TR:Q9F1Y4 (EMBL:AB035202) ORF5 (fragment). Contai [...]
  
    0.627
SCO7703
SCBAC12C8.04, possible integral membrane transport protein, len: 416aa: similar to many eg. TR:BAB35923 (EMBL:AP002558) putative amino acid/amine transport protein from Escherichia coli O157:H7 (393 aa) fasta scores; opt: 953, Z-score: 1012.0, 41.207% identity (41.645% ungapped) in 381 aa overlap. Contains Prosite match to PS00402 Binding-protein-dependent transport systems inner membrane comp sign. and multiple possible membrane-spanning hydrophobic regions.
       0.625
SCO3979
SCBAC25E3.16, possible TetR-family transcriptional regulator, len: 196 aa: similar to many from Streptomyces coelicolor e.g. TR:Q9RK21 (EMBL:AL109974) putative TetR-family transcriptional regulator SCF34.04 (203 aa) fasta scores; opt: 497, Z-score: 587.5, 43.750% identity (44.681% ungapped) in 192 aa overlap. Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family.
  
     0.597
SCO4871
SCK20.12, probable tetR-family transcriptional regulator, len: 216 aa; similar to SW:TER1_ECOLI (EMBL:X61367) Escherichia coli tetracycline repressor protein class A TetR, 216 aa; fasta scores: opt: 437 z-score: 544.2 E(): 8.9e-23; 43.2% identity in 199 aa overlap. Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family and possible helix-turn-helix motif at residues 30..51 (+5.12 SD).
  
     0.550
SCO1003
2SCG2.16, probable tetR-family transcriptional regulator, len: 194 aa; similar to TR:Q9RL21 (EMBL:AL117385) Streptomyces coelicolor putative transcriptional regulator SC5G9.05, 193 aa; fasta scores: opt: 408 z-score: 498.8 E(): 2.9e-20; 39.4% identity in 193 aa overlap. Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family. Also contains possible helix-turn-helix motif at residues 37..58 (+4.68 SD).
  
     0.497
SCO7659
SC10F4.32c, probable oxidoreductase, len: 373 aa; similar to SW:TETX_BACFR (EMBL:M37699) Bacteroides fragilis tetracycline resistance protein TetX, 388 aa; fasta scores: opt: 524 z-score: 576.3 E(): 1.4e-24; 30.2% identity in 374 aa overlap and to TR:CAB94636 (EMBL:AL359215) Streptomyces coelicolor hypothetical protein SC2H12.22, 373 aa; fasta scores: opt: 1709 z-score: 1482.3 E(): 0; 71.2% identity in 375 aa overlap. Contains Pfam match to entry PF01360 Monooxygenase, Monooxygenase.
 
     0.448
SCO7701
Putative methyltransferase; Catalyzes the SAM-dependent methylation of geranyl diphosphate (GPP) to yield (E)-2-methylgeranyl diphosphate (2-MeGPP).
       0.421
SCO2817
SCBAC17F8.08c, conserved hypothetical protein, len: 634 aa: similar in regions to many proteins of varying lengths e.g. TR:Q9RCY2 (EMBL:AL133469) hypothetical protein SCM10.16c from Streptomyces coelicolor (714 aa) fasta scores; opt: 1259, Z-score: 1358.4, 43.960% identity (46.454% ungapped) in 596 aa overlap and TR:Q9HVI8 (EMBL:AE004874) hypothetical protein from Pseudomonas aeruginosa (1415 aa) fasta scores; opt: 961, Z-score: 1032.5, 36.825% identity (40.250% ungapped) in 611 aa overlap. Contains Pfam match to entry PF00563 EAL, Domain of unknown function and Pfam match to entry PF0 [...]
  
 
 0.418
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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