STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Top2aDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1526 aa)    
Predicted Functional Partners:
Nusap1
Nucleolar and spindle-associated protein 1.
   
  
 0.988
Cdk1
Cell division control protein 2-like; Belongs to the protein kinase superfamily.
   
 
 0.981
Smc2
Structural maintenance of chromosomes protein 2.
   
 
 0.958
Ube2c
Ubiquitin-conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.958
I79_025391
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta.
   
  
 0.950
Top1mt
DNA topoisomerase I, mitochondrial.
   
 
 0.943
Cdc20
Cell division cycle protein 20-like.
  
 
 0.938
Espl1
Separin.
   
 
 0.938
H671_3g9632
Baculoviral IAP repeat-containing protein 5.
   
  
 0.934
Cenpf
Centromere protein F.
   
  
 0.933
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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